Src Inhibition Attenuates Liver Fibrosis by Preventing Hepatic Stellate Cell Activation and Decreasing Connective Tissue Growth Factor

Src Inhibition Attenuates Liver Fibrosis by Preventing Hepatic Stellate Cell Activation and Decreasing Connective Tissue Growth Factor

The SRC kinase family comprises non-receptor tyrosine kinases that are ubiquitously expressed in all cell types. Although Src is reportedly activated in pulmonary and renal fibrosis, little is known regarding its role in liver fibrosis. This study investigated whether the inhibition of Src protects...

Full description

Bibliographic Details
Main Authors:	Hye-Young Seo, So-Hee Lee, Ji-Ha Lee, Yu Na Kang, Jae Seok Hwang, Keun-Gyu Park, Mi Kyung Kim, Byoung Kuk Jang
Format:	Article
Language:	English
Published:	MDPI AG 2020-02-01
Series:	Cells
Subjects:	src saracatinib pp2 liver fibrosis hsc tgf-β hepatocyte ctgf smad3 autophagy
Online Access:	https://www.mdpi.com/2073-4409/9/3/558

Similar Items

Increased Levels of Phosphorylated ERK Induce CTGF Expression in Autophagy-Deficient Mouse Hepatocytes
by: Hye-Young Seo, et al.
Published: (2022-08-01)

Combating head and neck cancer metastases by targeting Src using multifunctional nanoparticle-based saracatinib
by: Liwei Lang, et al.
Published: (2018-06-01)

Simultaneously inactivating Src and AKT by saracatinib/capivasertib co-delivery nanoparticles to improve the efficacy of anti-Src therapy in head and neck squamous cell carcinoma
by: Liwei Lang, et al.
Published: (2019-12-01)

Hepatocyte-Specific Smad4 Deficiency Alleviates Liver Fibrosis via the p38/p65 Pathway
by: Miaomiao Wei, et al.
Published: (2022-10-01)

Saracatinib, a Src Tyrosine Kinase Inhibitor, as a Disease Modifier in the Rat DFP Model: Sex Differences, Neurobehavior, Gliosis, Neurodegeneration, and Nitro-Oxidative Stress
by: Meghan Gage, et al.
Published: (2021-12-01)

CCN2 Increases TGF-β Receptor Type II Expression in Vascular Smooth Muscle Cells: Essential Role of CCN2 in the TGF-β Pathway Regulation
by: Antonio Tejera-Muñoz, et al.
Published: (2021-12-01)

Differential regulation of TGF-β/Smad signaling in hepatic stallate cells between acute and chronic liver injuries
by: Katsunori eYoshida, et al.
Published: (2012-03-01)

Eucommia bark (Du-Zhong) improves diabetic nephropathy without altering blood glucose in type 1-like diabetic rats
by: Niu HS, et al.
Published: (2016-03-01)

Exploring the benefits of in-diet versus repeated oral dosing of saracatinib (AZD0530) in chronic studies: insights into pharmacokinetics and animal welfare
by: Suraj S. Vasanthi, et al.
Published: (2023-11-01)

Platelet Interactions with Liver Sinusoidal Endothelial Cells and Hepatic Stellate Cells Lead to Hepatocyte Proliferation
by: Jeremy Meyer, et al.
Published: (2020-05-01)

Kahweol Induces Apoptosis in Hepatocellular Carcinoma Cells by Inhibiting the Src/mTOR/STAT3 Signaling Pathway
by: Hye-Young Seo, et al.
Published: (2021-09-01)

Tamoxifen and Src kinase inhibitors as neuroprotective/neuroregenerative drugs after spinal cord injury
by: Iris K Salgado, et al.
Published: (2015-01-01)

Runx2 activates hepatic stellate cells to promote liver fibrosis via transcriptionally regulating Itgav expression
by: Li Zhong, et al.
Published: (2023-07-01)

Phenylethanol Glycosides from Cistanche tubulosa Suppress Hepatic Stellate Cell Activation and Block the Conduction of Signaling Pathways in TGF-β1/smad as Potential Anti-Hepatic Fibrosis Agents
by: Shu-Ping You, et al.
Published: (2016-01-01)

Saracatinib Inhibits Middle East Respiratory Syndrome-Coronavirus Replication In Vitro
by: Jin Soo Shin, et al.
Published: (2018-05-01)

Interplay of Matrix Stiffness and c-SRC in Hepatic Fibrosis.
by: Jan eGörtzen, et al.
Published: (2015-12-01)

Inhibitory effects of oxymatrine on hepatic stellate cells activation through TGF-β/miR-195/Smad signaling pathway
by: Li-Ying Song, et al.
Published: (2019-06-01)

The Upregulation of Leucine-Rich Repeat Containing 1 Expression Activates Hepatic Stellate Cells and Promotes Liver Fibrosis by Stabilizing Phosphorylated Smad2/3
by: Yake Wang, et al.
Published: (2024-02-01)

miR-185 Inhibits Fibrogenic Activation of Hepatic Stellate Cells and Prevents Liver Fibrosis
by: Li Zhou, et al.
Published: (2018-03-01)

Evogliptin Directly Inhibits Inflammatory and Fibrotic Signaling in Isolated Liver Cells
by: Hye-Young Seo, et al.
Published: (2022-10-01)

Fluorofenidone alleviates liver fibrosis by inhibiting hepatic stellate cell autophagy via the TGF-β1/Smad pathway: implications for liver cancer
by: Xiongqun Peng, et al.
Published: (2023-09-01)

IL-17A-Mediated Excessive Autophagy Aggravated Neuronal Ischemic Injuries via Src-PP2B-mTOR Pathway
by: Ting Liu, et al.
Published: (2019-12-01)

The Epithelial-to-Mesenchymal Transition as a Possible Therapeutic Target in Fibrotic Disorders
by: Jacopo Di Gregorio, et al.
Published: (2020-12-01)

Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-κB and TGF-β1/Smad3 pathways
by: Feng J, et al.
Published: (2018-06-01)

MEKK1, JNK, and SMAD3 mediate CXCL12-stimulated connective tissue growth factor expression in human lung fibroblasts
by: Chien-Huang Lin, et al.
Published: (2018-03-01)

Downregulation of Src Family Kinase Activity Using PP2 Inhibitor Has No Effect on the Elongation of Pragmin-Transfected Adenocarcinoma AGS cells
by: Fatemeh Safari, et al.
Published: (2018-03-01)

Oncogenic Role of Connective Tissue Growth Factor Is Associated with Canonical TGF-β Cascade in Colorectal Cancer
by: Shaghayegh Hosseini, et al.
Published: (2022-04-01)

Clinico-Pathological Importance of TGF-β/Phospho-Smad Signaling during Human Hepatic Fibrocarcinogenesis
by: Katsunori Yoshida, et al.
Published: (2018-06-01)

Structural and functional characterization of the divergent Entamoeba Src using Src inhibitor-1
by: Luilli López-Contreras, et al.
Published: (2017-10-01)

Epigallocatechin-3-gallate inhibits lysophosphatidic acid-stimulated connective tissue growth factor via JNK and Smad3 suppression in human gingival fibroblasts
by: Chen-Ying Wang, et al.
Published: (2014-01-01)

Nuclear deformation mediates liver cell mechanosensing in cirrhosis
by: Sergi Guixé-Muntet, et al.
Published: (2020-10-01)

Adipose-Derived Stem Cells (ADSCs) Supplemented with Hepatocyte Growth Factor (HGF) Attenuate Hepatic Stellate Cell Activation and Liver Fibrosis by Inhibiting the TGF-β/Smad Signaling Pathway in Chemical-Induced Liver Fibrosis Associated with Diabetes
by: Sami Gharbia, et al.
Published: (2022-10-01)

Irradiation induces DJ-1 secretion from esophageal squamous cell carcinoma cells to accelerate metastasis of bystander cells via a TGF-β1 positive feedback loop
by: Junjie Gu, et al.
Published: (2022-08-01)

Endocytosis and the Src family of non-receptor tyrosine kinases
by: Reinecke James, et al.
Published: (2014-05-01)

The role of green peas protein hydrolysate in TGF/SMAD signaling to prevent renal fibrosis
by: Meilinah Hidayat, et al.
Published: (2022-06-01)

Role of c-Src in Carcinogenesis and Drug Resistance
by: Lukmon Raji, et al.
Published: (2023-12-01)

Phosphorylation of Unique domains of Src family kinases
by: Irene eAmata, et al.
Published: (2014-06-01)

Implications of the Estrogen Receptor Coactivators SRC1 and SRC2 in the Biological Basis of Gender Incongruence
by: Karla del Valle Ramírez, Pre-doc, et al.
Published: (2021-06-01)

Human placental mesenchymal stem cells ameliorate liver fibrosis in mice by upregulation of Caveolin1 in hepatic stellate cells
by: Yunqi Yao, et al.
Published: (2021-05-01)

Investigation of SMAD3 and SMAD4 Genes Expression in CML Patients and K562 Cell Line
by: T Mahdloo, et al.
Published: (2023-04-01)