Peptide-Based Strategies for Targeted Tumor Treatment and Imaging
Cancer is one of the leading causes of death worldwide. The development of cancer-specific diagnostic agents and anticancer toxins would improve patient survival. The current and standard types of medical care for cancer patients, including surgery, radiotherapy, and chemotherapy, are not able to tr...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/13/4/481 |
| _version_ | 1797539080990359552 |
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| author | Abiodun Ayo Pirjo Laakkonen |
| author_facet | Abiodun Ayo Pirjo Laakkonen |
| author_sort | Abiodun Ayo |
| collection | DOAJ |
| description | Cancer is one of the leading causes of death worldwide. The development of cancer-specific diagnostic agents and anticancer toxins would improve patient survival. The current and standard types of medical care for cancer patients, including surgery, radiotherapy, and chemotherapy, are not able to treat all cancers. A new treatment strategy utilizing tumor targeting peptides to selectively deliver drugs or applicable active agents to solid tumors is becoming a promising approach. In this review, we discuss the different tumor-homing peptides discovered through combinatorial library screening, as well as native active peptides. The different structure–function relationship data that have been used to improve the peptide’s activity and conjugation strategies are highlighted. |
| first_indexed | 2024-03-10T12:40:14Z |
| format | Article |
| id | doaj.art-07eb2ce8f9e54811aceee52c3f751b56 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T12:40:14Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-07eb2ce8f9e54811aceee52c3f751b562023-11-21T13:55:31ZengMDPI AGPharmaceutics1999-49232021-04-0113448110.3390/pharmaceutics13040481Peptide-Based Strategies for Targeted Tumor Treatment and ImagingAbiodun Ayo0Pirjo Laakkonen1Translational Cancer Medicine Research Program, Faculty of Medicine, University of Helsinki, 00014 Helsinki, FinlandTranslational Cancer Medicine Research Program, Faculty of Medicine, University of Helsinki, 00014 Helsinki, FinlandCancer is one of the leading causes of death worldwide. The development of cancer-specific diagnostic agents and anticancer toxins would improve patient survival. The current and standard types of medical care for cancer patients, including surgery, radiotherapy, and chemotherapy, are not able to treat all cancers. A new treatment strategy utilizing tumor targeting peptides to selectively deliver drugs or applicable active agents to solid tumors is becoming a promising approach. In this review, we discuss the different tumor-homing peptides discovered through combinatorial library screening, as well as native active peptides. The different structure–function relationship data that have been used to improve the peptide’s activity and conjugation strategies are highlighted.https://www.mdpi.com/1999-4923/13/4/481tumor homing peptidesdrug deliverytargeted delivery |
| spellingShingle | Abiodun Ayo Pirjo Laakkonen Peptide-Based Strategies for Targeted Tumor Treatment and Imaging Pharmaceutics tumor homing peptides drug delivery targeted delivery |
| title | Peptide-Based Strategies for Targeted Tumor Treatment and Imaging |
| title_full | Peptide-Based Strategies for Targeted Tumor Treatment and Imaging |
| title_fullStr | Peptide-Based Strategies for Targeted Tumor Treatment and Imaging |
| title_full_unstemmed | Peptide-Based Strategies for Targeted Tumor Treatment and Imaging |
| title_short | Peptide-Based Strategies for Targeted Tumor Treatment and Imaging |
| title_sort | peptide based strategies for targeted tumor treatment and imaging |
| topic | tumor homing peptides drug delivery targeted delivery |
| url | https://www.mdpi.com/1999-4923/13/4/481 |
| work_keys_str_mv | AT abiodunayo peptidebasedstrategiesfortargetedtumortreatmentandimaging AT pirjolaakkonen peptidebasedstrategiesfortargetedtumortreatmentandimaging |