Loss of the extracellular matrix protein Perlecan disrupts axonal and synaptic stability during Drosophila development

Loss of the extracellular matrix protein Perlecan disrupts axonal and synaptic stability during Drosophila development

Heparan sulfate proteoglycans (HSPGs) form essential components of the extracellular matrix (ECM) and basement membrane (BM) and have both structural and signaling roles. Perlecan is a secreted ECM-localized HSPG that contributes to tissue integrity and cell-cell communication. Although a core compo...

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Bibliographic Details
Main Authors: Ellen J Guss, Yulia Akbergenova, Karen L Cunningham, J Troy Littleton
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-06-01
Series:eLife
Subjects:
extracellular matrix
synapse retraction
axonal degeneration
cytoskeleton
collagen
Online Access:https://elifesciences.org/articles/88273

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