Tepung ulat sagu (Rhyinchophorus ferrugineus) imunomodulator Nitric Oxide (NO) sirkulasi mencit terapi antimalaria standar
Background : Sago worm flour (Rhyinchophorus ferrugineus)is a coconut beetle larvae that is processed into flour.This flour contains antioxidants as well as arginine, both of which play a role in modulating oxidative stress including NO involved in immunopathology of cerebral malaria.Objectives : To...
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| Format: | Article |
| Language: | Indonesian |
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Diponegoro University
2018-08-01
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| Series: | Jurnal Gizi Indonesia: The Indonesian Journal of Nutrition |
| Subjects: | |
| Online Access: | https://ejournal.undip.ac.id/index.php/jgi/article/view/19119 |
| _version_ | 1818560169280274432 |
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| author | Ariani Ariani Gemala Anjani Muchlis Achsan Udji Sofro Kis Djamiatun |
| author_facet | Ariani Ariani Gemala Anjani Muchlis Achsan Udji Sofro Kis Djamiatun |
| author_sort | Ariani Ariani |
| collection | DOAJ |
| description | Background : Sago worm flour (Rhyinchophorus ferrugineus)is a coconut beetle larvae that is processed into flour.This flour contains antioxidants as well as arginine, both of which play a role in modulating oxidative stress including NO involved in immunopathology of cerebral malaria.Objectives : To prove the immunomodulator role of sago worm flour in decreasing circulation NO level at mice who received standard antimalarial therapy Dihydroartemisinin Piperaquine (DHP)Methods : This study was randomized control group post test only design by using 23 Swiss mice which divided into 5 group consist of : K(-) normal mice; K(+) inoculated woth Plasmodium berghei ANKA (PbA); X1 received DHP; X2 received sago worm flour; X3 received both of sago worm flour and DHP. All treatment groups X1,X2 and X3 were inoculated by PbA before treatmen were given. Serum circulation NO level was assessed by ELISA. statistical analysis used was One Way ANOVA followed by Bonferroni post hoc test.
Results : The mean NO level in K(-), K(+), X1, X2, and X3 were 1.008 μmol/mL, K(+) 1.338 μmol/mL; while at treatment X1 1.143 μmol/mL, X2 1.410 μmol/mL, dan X3 0.886 μmol/mL. One way ANOVA showed that they were significantly different (p=0.001). Bonferroni post hoc test of X2 was proportional to K(+) (p=1.000), whole had NO level lower than either K(+)(p=0.009) or X2 (p=0.002).
Conclusion : The immunomodulatory effects of sago worm flour (Rhyinchophorus ferrugineus) reduced circulating NO levels in standard antimalarial therapy recipients. |
| first_indexed | 2024-12-14T00:35:02Z |
| format | Article |
| id | doaj.art-07efa8899a9145b99f0fed78a255a734 |
| institution | Directory Open Access Journal |
| issn | 1858-4942 2338-3119 |
| language | Indonesian |
| last_indexed | 2024-12-14T00:35:02Z |
| publishDate | 2018-08-01 |
| publisher | Diponegoro University |
| record_format | Article |
| series | Jurnal Gizi Indonesia: The Indonesian Journal of Nutrition |
| spelling | doaj.art-07efa8899a9145b99f0fed78a255a7342022-12-21T23:24:42ZindDiponegoro UniversityJurnal Gizi Indonesia: The Indonesian Journal of Nutrition1858-49422338-31192018-08-016213113810.14710/jgi.6.2.131-13813589Tepung ulat sagu (Rhyinchophorus ferrugineus) imunomodulator Nitric Oxide (NO) sirkulasi mencit terapi antimalaria standarAriani Ariani0Gemala Anjani1Muchlis Achsan Udji Sofro2Kis Djamiatun3Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas DiponegoroDepartemen Ilmu Gizi, Fakultas Kedokteran, Universitas DiponegoroIlmu Penyakit Dalam, RS. Kariadi Semarang, Fakultas Kedokteran, Universitas DiponegoroParasitologi, Fakultas Kedokteran, Universitas DiponegoroBackground : Sago worm flour (Rhyinchophorus ferrugineus)is a coconut beetle larvae that is processed into flour.This flour contains antioxidants as well as arginine, both of which play a role in modulating oxidative stress including NO involved in immunopathology of cerebral malaria.Objectives : To prove the immunomodulator role of sago worm flour in decreasing circulation NO level at mice who received standard antimalarial therapy Dihydroartemisinin Piperaquine (DHP)Methods : This study was randomized control group post test only design by using 23 Swiss mice which divided into 5 group consist of : K(-) normal mice; K(+) inoculated woth Plasmodium berghei ANKA (PbA); X1 received DHP; X2 received sago worm flour; X3 received both of sago worm flour and DHP. All treatment groups X1,X2 and X3 were inoculated by PbA before treatmen were given. Serum circulation NO level was assessed by ELISA. statistical analysis used was One Way ANOVA followed by Bonferroni post hoc test. Results : The mean NO level in K(-), K(+), X1, X2, and X3 were 1.008 μmol/mL, K(+) 1.338 μmol/mL; while at treatment X1 1.143 μmol/mL, X2 1.410 μmol/mL, dan X3 0.886 μmol/mL. One way ANOVA showed that they were significantly different (p=0.001). Bonferroni post hoc test of X2 was proportional to K(+) (p=1.000), whole had NO level lower than either K(+)(p=0.009) or X2 (p=0.002). Conclusion : The immunomodulatory effects of sago worm flour (Rhyinchophorus ferrugineus) reduced circulating NO levels in standard antimalarial therapy recipients.https://ejournal.undip.ac.id/index.php/jgi/article/view/19119Sago worm, Plasmodium berghei ANKA (PbA), NO |
| spellingShingle | Ariani Ariani Gemala Anjani Muchlis Achsan Udji Sofro Kis Djamiatun Tepung ulat sagu (Rhyinchophorus ferrugineus) imunomodulator Nitric Oxide (NO) sirkulasi mencit terapi antimalaria standar Jurnal Gizi Indonesia: The Indonesian Journal of Nutrition Sago worm, Plasmodium berghei ANKA (PbA), NO |
| title | Tepung ulat sagu (Rhyinchophorus ferrugineus) imunomodulator Nitric Oxide (NO) sirkulasi mencit terapi antimalaria standar |
| title_full | Tepung ulat sagu (Rhyinchophorus ferrugineus) imunomodulator Nitric Oxide (NO) sirkulasi mencit terapi antimalaria standar |
| title_fullStr | Tepung ulat sagu (Rhyinchophorus ferrugineus) imunomodulator Nitric Oxide (NO) sirkulasi mencit terapi antimalaria standar |
| title_full_unstemmed | Tepung ulat sagu (Rhyinchophorus ferrugineus) imunomodulator Nitric Oxide (NO) sirkulasi mencit terapi antimalaria standar |
| title_short | Tepung ulat sagu (Rhyinchophorus ferrugineus) imunomodulator Nitric Oxide (NO) sirkulasi mencit terapi antimalaria standar |
| title_sort | tepung ulat sagu rhyinchophorus ferrugineus imunomodulator nitric oxide no sirkulasi mencit terapi antimalaria standar |
| topic | Sago worm, Plasmodium berghei ANKA (PbA), NO |
| url | https://ejournal.undip.ac.id/index.php/jgi/article/view/19119 |
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