Efficacy of intralesional tranexamic acid in melasma: Assessment with Melasma Area Severity Index and Dermatology Quality of Life Index
Background and Design: Melasma is a common hypermelanotic condition, mostly observed in women, which affects their psychological, emotional, and social well-being as well as their quality of life. Although melasma is relatively resistant to treatment, various therapeutic options have been attempted...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2022-06-01
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| Series: | Turkderm Turkish Archives of Dermatology and Venereology |
| Subjects: | |
| Online Access: | https://journal.turkderm.org.tr/jvi.aspx?pdir=turkderm&plng=eng&un=TURKDERM-42709&look4= |
| _version_ | 1797923136884178944 |
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| author | Sneha Krishnoji Rao Rajashekar T. S. Ashna Ashraf |
| author_facet | Sneha Krishnoji Rao Rajashekar T. S. Ashna Ashraf |
| author_sort | Sneha Krishnoji Rao |
| collection | DOAJ |
| description | Background and Design: Melasma is a common hypermelanotic condition, mostly observed in women, which affects their psychological, emotional, and social well-being as well as their quality of life. Although melasma is relatively resistant to treatment, various therapeutic options have been attempted until date. Recently, microneedling and microinjection tranexamic acid were performed. To compare the therapeutic effectiveness of triple combination therapy with tranexamic acid injection and assess the impact of response on melasma by comparing the pre- and post-treatment Melasma Area Severity Index (MASI) and Dermatology Quality of Life Index (DLQI) scores. Materials and Methods: A total of 70 melasma patients were selected and assigned to two groups of 35 patients each based on the interventional randomized control study. One group was treated with a topical triple combination therapy-hydroquinone (2%), mometasone (0.1%), and tretinoin (0.025%), and the other group with injectable tranexamic acid. The MASI scores and DLQI were assessed for both the groups of patients at the baseline and then 6 weeks later along with serial photographs.
Results: Significant reduction in MASI and DLQI scores were noted in the intralesional tranexamic acid group of patients (p=0.032). The mean change in MASI with tranexamic acid was 1.22 and with DLQI was 2.03.
Conclusion: Injectable tranexamic acid is a promising treatment option for melasma. Further studies are however warranted with a larger sample size and for a longer duration to determine its long-term benefits. Treatment of melasma is beneficial for the patient both physically and emotionally. |
| first_indexed | 2024-04-10T14:42:10Z |
| format | Article |
| id | doaj.art-07f054cb28444860adc2afefa0c2dc21 |
| institution | Directory Open Access Journal |
| issn | 2651-5164 |
| language | English |
| last_indexed | 2024-04-10T14:42:10Z |
| publishDate | 2022-06-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkderm Turkish Archives of Dermatology and Venereology |
| spelling | doaj.art-07f054cb28444860adc2afefa0c2dc212023-02-15T16:08:05ZengGalenos Publishing HouseTurkderm Turkish Archives of Dermatology and Venereology2651-51642022-06-01562586310.4274/turkderm.galenos.2022.42709Efficacy of intralesional tranexamic acid in melasma: Assessment with Melasma Area Severity Index and Dermatology Quality of Life IndexSneha Krishnoji Rao0https://orcid.org/0000-0003-3798-8107Rajashekar T. S.1https://orcid.org/0000-0002-8927-6729Ashna Ashraf2https://orcid.org/0000-0003-0235-6097Sri Devaraj Urs Medical College, Department of Dermatology, Venereology and Leprosy, Kolar, IndiaSri Devaraj Urs Medical College, Department of Dermatology, Venereology and Leprosy, Kolar, IndiaSri Devaraj Urs Medical College, Department of Dermatology, Venereology and Leprosy, Kolar, IndiaBackground and Design: Melasma is a common hypermelanotic condition, mostly observed in women, which affects their psychological, emotional, and social well-being as well as their quality of life. Although melasma is relatively resistant to treatment, various therapeutic options have been attempted until date. Recently, microneedling and microinjection tranexamic acid were performed. To compare the therapeutic effectiveness of triple combination therapy with tranexamic acid injection and assess the impact of response on melasma by comparing the pre- and post-treatment Melasma Area Severity Index (MASI) and Dermatology Quality of Life Index (DLQI) scores. Materials and Methods: A total of 70 melasma patients were selected and assigned to two groups of 35 patients each based on the interventional randomized control study. One group was treated with a topical triple combination therapy-hydroquinone (2%), mometasone (0.1%), and tretinoin (0.025%), and the other group with injectable tranexamic acid. The MASI scores and DLQI were assessed for both the groups of patients at the baseline and then 6 weeks later along with serial photographs. Results: Significant reduction in MASI and DLQI scores were noted in the intralesional tranexamic acid group of patients (p=0.032). The mean change in MASI with tranexamic acid was 1.22 and with DLQI was 2.03. Conclusion: Injectable tranexamic acid is a promising treatment option for melasma. Further studies are however warranted with a larger sample size and for a longer duration to determine its long-term benefits. Treatment of melasma is beneficial for the patient both physically and emotionally.https://journal.turkderm.org.tr/jvi.aspx?pdir=turkderm&plng=eng&un=TURKDERM-42709&look4=intralesional tranexamic acidmelasma area severity indexdermatology life quality index |
| spellingShingle | Sneha Krishnoji Rao Rajashekar T. S. Ashna Ashraf Efficacy of intralesional tranexamic acid in melasma: Assessment with Melasma Area Severity Index and Dermatology Quality of Life Index Turkderm Turkish Archives of Dermatology and Venereology intralesional tranexamic acid melasma area severity index dermatology life quality index |
| title | Efficacy of intralesional tranexamic acid in melasma: Assessment with Melasma Area Severity Index and Dermatology Quality of Life Index |
| title_full | Efficacy of intralesional tranexamic acid in melasma: Assessment with Melasma Area Severity Index and Dermatology Quality of Life Index |
| title_fullStr | Efficacy of intralesional tranexamic acid in melasma: Assessment with Melasma Area Severity Index and Dermatology Quality of Life Index |
| title_full_unstemmed | Efficacy of intralesional tranexamic acid in melasma: Assessment with Melasma Area Severity Index and Dermatology Quality of Life Index |
| title_short | Efficacy of intralesional tranexamic acid in melasma: Assessment with Melasma Area Severity Index and Dermatology Quality of Life Index |
| title_sort | efficacy of intralesional tranexamic acid in melasma assessment with melasma area severity index and dermatology quality of life index |
| topic | intralesional tranexamic acid melasma area severity index dermatology life quality index |
| url | https://journal.turkderm.org.tr/jvi.aspx?pdir=turkderm&plng=eng&un=TURKDERM-42709&look4= |
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