DNA Homeostasis and Senescence: Lessons from the Naked Mole Rat
As we age, our bodies accrue damage in the form of DNA mutations. These mutations lead to the generation of sub-optimal proteins, resulting in inadequate cellular homeostasis and senescence. The build-up of senescent cells negatively affects the local cellular micro-environment and drives ageing ass...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/11/6011 |
| _version_ | 1797531632450666496 |
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| author | Harvey Boughey Mateusz Jurga Sherif F. El-Khamisy |
| author_facet | Harvey Boughey Mateusz Jurga Sherif F. El-Khamisy |
| author_sort | Harvey Boughey |
| collection | DOAJ |
| description | As we age, our bodies accrue damage in the form of DNA mutations. These mutations lead to the generation of sub-optimal proteins, resulting in inadequate cellular homeostasis and senescence. The build-up of senescent cells negatively affects the local cellular micro-environment and drives ageing associated disease, including neurodegeneration. Therefore, limiting the accumulation of DNA damage is essential for healthy neuronal populations. The naked mole rats (NMR) are from eastern Africa and can live for over three decades in chronically hypoxic environments. Despite their long lifespan, NMRs show little to no biological decline, neurodegeneration, or senescence. Here, we discuss molecular pathways and adaptations that NMRs employ to maintain genome integrity and combat the physiological and pathological decline in organismal function. |
| first_indexed | 2024-03-10T10:46:29Z |
| format | Article |
| id | doaj.art-07f2427156174a6d940c348be946464c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T10:46:29Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-07f2427156174a6d940c348be946464c2023-11-21T22:31:49ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-012211601110.3390/ijms22116011DNA Homeostasis and Senescence: Lessons from the Naked Mole RatHarvey Boughey0Mateusz Jurga1Sherif F. El-Khamisy2The Healthy Lifespan Institute and the Institute of Neuroscience, University of Sheffield, Sheffield S10 2TN, UKThe Institute of Cancer Therapeutics, University of Bradford, Bradford BD7 1DP, UKThe Healthy Lifespan Institute and the Institute of Neuroscience, University of Sheffield, Sheffield S10 2TN, UKAs we age, our bodies accrue damage in the form of DNA mutations. These mutations lead to the generation of sub-optimal proteins, resulting in inadequate cellular homeostasis and senescence. The build-up of senescent cells negatively affects the local cellular micro-environment and drives ageing associated disease, including neurodegeneration. Therefore, limiting the accumulation of DNA damage is essential for healthy neuronal populations. The naked mole rats (NMR) are from eastern Africa and can live for over three decades in chronically hypoxic environments. Despite their long lifespan, NMRs show little to no biological decline, neurodegeneration, or senescence. Here, we discuss molecular pathways and adaptations that NMRs employ to maintain genome integrity and combat the physiological and pathological decline in organismal function.https://www.mdpi.com/1422-0067/22/11/6011naked mole ratsenescenceneurodegenerationageingDNA damageDNA repair |
| spellingShingle | Harvey Boughey Mateusz Jurga Sherif F. El-Khamisy DNA Homeostasis and Senescence: Lessons from the Naked Mole Rat International Journal of Molecular Sciences naked mole rat senescence neurodegeneration ageing DNA damage DNA repair |
| title | DNA Homeostasis and Senescence: Lessons from the Naked Mole Rat |
| title_full | DNA Homeostasis and Senescence: Lessons from the Naked Mole Rat |
| title_fullStr | DNA Homeostasis and Senescence: Lessons from the Naked Mole Rat |
| title_full_unstemmed | DNA Homeostasis and Senescence: Lessons from the Naked Mole Rat |
| title_short | DNA Homeostasis and Senescence: Lessons from the Naked Mole Rat |
| title_sort | dna homeostasis and senescence lessons from the naked mole rat |
| topic | naked mole rat senescence neurodegeneration ageing DNA damage DNA repair |
| url | https://www.mdpi.com/1422-0067/22/11/6011 |
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