Nordihydroguaiaretic Acid: From Herbal Medicine to Clinical Development for Cancer and Chronic Diseases
Nordihydroguaiaretic acid (NDGA) is a phenolic lignan obtained from Larrea tridentata, the creosote bush found in Mexico and USA deserts, that has been used in traditional medicine for the treatment of numerous diseases such as cancer, renal, cardiovascular, immunological, and neurological disorders...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-02-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2020.00151/full |
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| author | Gina Manda Ana I. Rojo Elena Martínez-Klimova José Pedraza-Chaverri Antonio Cuadrado Antonio Cuadrado |
| author_facet | Gina Manda Ana I. Rojo Elena Martínez-Klimova José Pedraza-Chaverri Antonio Cuadrado Antonio Cuadrado |
| author_sort | Gina Manda |
| collection | DOAJ |
| description | Nordihydroguaiaretic acid (NDGA) is a phenolic lignan obtained from Larrea tridentata, the creosote bush found in Mexico and USA deserts, that has been used in traditional medicine for the treatment of numerous diseases such as cancer, renal, cardiovascular, immunological, and neurological disorders, and even aging. NDGA presents two catechol rings that confer a very potent antioxidant activity by scavenging oxygen free radicals and this may explain part of its therapeutic action. Additional effects include inhibition of lipoxygenases (LOXs) and activation of signaling pathways that impinge on the transcription factor Nuclear Factor Erythroid 2-related Factor (NRF2). On the other hand, the oxidation of the catechols to the corresponding quinones my elicit alterations in proteins and DNA that raise safety concerns. This review describes the current knowledge on NDGA, its targets and side effects, and its synthetic analogs as promising therapeutic agents, highlighting their mechanism of action and clinical projection towards therapy of neurodegenerative, liver, and kidney disease, as well as cancer. |
| first_indexed | 2024-12-21T12:16:52Z |
| format | Article |
| id | doaj.art-07f29b4ebb2b448881aa6413a64d8a7b |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-21T12:16:52Z |
| publishDate | 2020-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-07f29b4ebb2b448881aa6413a64d8a7b2022-12-21T19:04:25ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122020-02-011110.3389/fphar.2020.00151500770Nordihydroguaiaretic Acid: From Herbal Medicine to Clinical Development for Cancer and Chronic DiseasesGina Manda0Ana I. Rojo1Elena Martínez-Klimova2José Pedraza-Chaverri3Antonio Cuadrado4Antonio Cuadrado5Department Cellular and Molecular Medicine, Victor Babes National Institute of Pathology, Bucharest, RomaniaDepartment of Biochemistry, Faculty of Medicine, Autonomous University of Madrid, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Investigación Sanitaria la Paz (idiPAZ), Instituto de Investigaciones Biomédicas “Alberto Sols” UAM-CSIC, Madrid, SpainDepartment of Biology, Faculty of Chemistry, National Autonomous University of Mexico (UNAM), Mexico City, MexicoDepartment of Biology, Faculty of Chemistry, National Autonomous University of Mexico (UNAM), Mexico City, MexicoDepartment Cellular and Molecular Medicine, Victor Babes National Institute of Pathology, Bucharest, RomaniaDepartment of Biochemistry, Faculty of Medicine, Autonomous University of Madrid, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Investigación Sanitaria la Paz (idiPAZ), Instituto de Investigaciones Biomédicas “Alberto Sols” UAM-CSIC, Madrid, SpainNordihydroguaiaretic acid (NDGA) is a phenolic lignan obtained from Larrea tridentata, the creosote bush found in Mexico and USA deserts, that has been used in traditional medicine for the treatment of numerous diseases such as cancer, renal, cardiovascular, immunological, and neurological disorders, and even aging. NDGA presents two catechol rings that confer a very potent antioxidant activity by scavenging oxygen free radicals and this may explain part of its therapeutic action. Additional effects include inhibition of lipoxygenases (LOXs) and activation of signaling pathways that impinge on the transcription factor Nuclear Factor Erythroid 2-related Factor (NRF2). On the other hand, the oxidation of the catechols to the corresponding quinones my elicit alterations in proteins and DNA that raise safety concerns. This review describes the current knowledge on NDGA, its targets and side effects, and its synthetic analogs as promising therapeutic agents, highlighting their mechanism of action and clinical projection towards therapy of neurodegenerative, liver, and kidney disease, as well as cancer.https://www.frontiersin.org/article/10.3389/fphar.2020.00151/fullcatecholquinoneelectrophilesNRF2KEAP1cytoprotection |
| spellingShingle | Gina Manda Ana I. Rojo Elena Martínez-Klimova José Pedraza-Chaverri Antonio Cuadrado Antonio Cuadrado Nordihydroguaiaretic Acid: From Herbal Medicine to Clinical Development for Cancer and Chronic Diseases Frontiers in Pharmacology catechol quinone electrophiles NRF2 KEAP1 cytoprotection |
| title | Nordihydroguaiaretic Acid: From Herbal Medicine to Clinical Development for Cancer and Chronic Diseases |
| title_full | Nordihydroguaiaretic Acid: From Herbal Medicine to Clinical Development for Cancer and Chronic Diseases |
| title_fullStr | Nordihydroguaiaretic Acid: From Herbal Medicine to Clinical Development for Cancer and Chronic Diseases |
| title_full_unstemmed | Nordihydroguaiaretic Acid: From Herbal Medicine to Clinical Development for Cancer and Chronic Diseases |
| title_short | Nordihydroguaiaretic Acid: From Herbal Medicine to Clinical Development for Cancer and Chronic Diseases |
| title_sort | nordihydroguaiaretic acid from herbal medicine to clinical development for cancer and chronic diseases |
| topic | catechol quinone electrophiles NRF2 KEAP1 cytoprotection |
| url | https://www.frontiersin.org/article/10.3389/fphar.2020.00151/full |
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