Chk1 suppressed cell death
<p>Abstract</p> <p>The role of Chk1 in the cellular response to DNA replication stress is well established. However recent work indicates a novel role for Chk1 in the suppression of apoptosis following the disruption of DNA replication or DNA damage. This review will consider these...
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| Format: | Article |
| Language: | English |
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BMC
2010-09-01
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| Series: | Cell Division |
| Online Access: | http://www.celldiv.com/content/5/1/21 |
| _version_ | 1818143813292523520 |
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| author | Meuth Mark |
| author_facet | Meuth Mark |
| author_sort | Meuth Mark |
| collection | DOAJ |
| description | <p>Abstract</p> <p>The role of Chk1 in the cellular response to DNA replication stress is well established. However recent work indicates a novel role for Chk1 in the suppression of apoptosis following the disruption of DNA replication or DNA damage. This review will consider these findings in the context of known pathways of Chk1 signalling and potential applications of therapies that target Chk1.</p> |
| first_indexed | 2024-12-11T11:37:38Z |
| format | Article |
| id | doaj.art-07f39c1d5a214d5d8edf985c442db89a |
| institution | Directory Open Access Journal |
| issn | 1747-1028 |
| language | English |
| last_indexed | 2024-12-11T11:37:38Z |
| publishDate | 2010-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Division |
| spelling | doaj.art-07f39c1d5a214d5d8edf985c442db89a2022-12-22T01:08:42ZengBMCCell Division1747-10282010-09-01512110.1186/1747-1028-5-21Chk1 suppressed cell deathMeuth Mark<p>Abstract</p> <p>The role of Chk1 in the cellular response to DNA replication stress is well established. However recent work indicates a novel role for Chk1 in the suppression of apoptosis following the disruption of DNA replication or DNA damage. This review will consider these findings in the context of known pathways of Chk1 signalling and potential applications of therapies that target Chk1.</p>http://www.celldiv.com/content/5/1/21 |
| spellingShingle | Meuth Mark Chk1 suppressed cell death Cell Division |
| title | Chk1 suppressed cell death |
| title_full | Chk1 suppressed cell death |
| title_fullStr | Chk1 suppressed cell death |
| title_full_unstemmed | Chk1 suppressed cell death |
| title_short | Chk1 suppressed cell death |
| title_sort | chk1 suppressed cell death |
| url | http://www.celldiv.com/content/5/1/21 |
| work_keys_str_mv | AT meuthmark chk1suppressedcelldeath |