Does the Decrease in Neutrophil-lymphocyte Ratio after BCG Treatment Be a Prognostic Marker for NMIBC?
Objective:Non-muscle invasive bladder cancer (NMIBC) accounts for 75% of all bladder cancer cases. Several models to predict relapses and progression have been developed. We aimed to determine the predictive value of the neutrophil-lymphocyte ratio (NLR) for recurrence and/or progression of the dise...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2020-12-01
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| Series: | Journal of Urological Surgery |
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| Online Access: |
http://jurolsurgery.org/archives/archive-detail/article-preview/does-the-decrease-in-neutrophil-lymphocyte-ratio-a/42817
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| _version_ | 1797913036395118592 |
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| author | Aykut Başer |
| author_facet | Aykut Başer |
| author_sort | Aykut Başer |
| collection | DOAJ |
| description | Objective:Non-muscle invasive bladder cancer (NMIBC) accounts for 75% of all bladder cancer cases. Several models to predict relapses and progression have been developed. We aimed to determine the predictive value of the neutrophil-lymphocyte ratio (NLR) for recurrence and/or progression of the disease.Materials and Methods:Seventy patients with high-risk NMIBC according to the European Organization for Research and Treatment of Cancer (EORTC) risk classification who were receiving Bacillus Calmette-Guerin (BCG) treatment and were followed up at our clinic were included in the study.Results:The average score level and NLR values differed significantly on patient classification according to the EORTC Progression and Recurrence Risk score. The positive correlations among EORTC Recurrence score, EORTC Progression score, Club Urológico Espanol de Tratamiento Oncológico (CUETO) Recurrence score, and CUETO Progression score and NLR values were not statistically significant. The NLR values decreased significantly on follow-ups on BCG treatment.Conclusion:Patients with bladder cancer have a high NLR, which has predictive utility with regard to prognosis. A decrease in NLR with BCG treatment is indicative of the decreased likelihood of recurrence and progression. |
| first_indexed | 2024-04-10T12:05:26Z |
| format | Article |
| id | doaj.art-07f5e311ea464026baa2630d9ceecd76 |
| institution | Directory Open Access Journal |
| issn | 2148-9580 2148-9580 |
| language | English |
| last_indexed | 2024-04-10T12:05:26Z |
| publishDate | 2020-12-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Journal of Urological Surgery |
| spelling | doaj.art-07f5e311ea464026baa2630d9ceecd762023-02-15T16:16:17ZengGalenos YayineviJournal of Urological Surgery2148-95802148-95802020-12-017427127510.4274/jus.galenos.2020.334213049054Does the Decrease in Neutrophil-lymphocyte Ratio after BCG Treatment Be a Prognostic Marker for NMIBC?Aykut Başer0 Hitit University Faculty of Medicine, Department of Urology, Çorum, Turkiye Objective:Non-muscle invasive bladder cancer (NMIBC) accounts for 75% of all bladder cancer cases. Several models to predict relapses and progression have been developed. We aimed to determine the predictive value of the neutrophil-lymphocyte ratio (NLR) for recurrence and/or progression of the disease.Materials and Methods:Seventy patients with high-risk NMIBC according to the European Organization for Research and Treatment of Cancer (EORTC) risk classification who were receiving Bacillus Calmette-Guerin (BCG) treatment and were followed up at our clinic were included in the study.Results:The average score level and NLR values differed significantly on patient classification according to the EORTC Progression and Recurrence Risk score. The positive correlations among EORTC Recurrence score, EORTC Progression score, Club Urológico Espanol de Tratamiento Oncológico (CUETO) Recurrence score, and CUETO Progression score and NLR values were not statistically significant. The NLR values decreased significantly on follow-ups on BCG treatment.Conclusion:Patients with bladder cancer have a high NLR, which has predictive utility with regard to prognosis. A decrease in NLR with BCG treatment is indicative of the decreased likelihood of recurrence and progression. http://jurolsurgery.org/archives/archive-detail/article-preview/does-the-decrease-in-neutrophil-lymphocyte-ratio-a/42817 non-muscle invasive bladder cancerneutrophil-lymphocyte ratiobcg treatmenteortc risk classificationprogressionrecurrence |
| spellingShingle | Aykut Başer Does the Decrease in Neutrophil-lymphocyte Ratio after BCG Treatment Be a Prognostic Marker for NMIBC? Journal of Urological Surgery non-muscle invasive bladder cancer neutrophil-lymphocyte ratio bcg treatment eortc risk classification progression recurrence |
| title | Does the Decrease in Neutrophil-lymphocyte Ratio after BCG Treatment Be a Prognostic Marker for NMIBC? |
| title_full | Does the Decrease in Neutrophil-lymphocyte Ratio after BCG Treatment Be a Prognostic Marker for NMIBC? |
| title_fullStr | Does the Decrease in Neutrophil-lymphocyte Ratio after BCG Treatment Be a Prognostic Marker for NMIBC? |
| title_full_unstemmed | Does the Decrease in Neutrophil-lymphocyte Ratio after BCG Treatment Be a Prognostic Marker for NMIBC? |
| title_short | Does the Decrease in Neutrophil-lymphocyte Ratio after BCG Treatment Be a Prognostic Marker for NMIBC? |
| title_sort | does the decrease in neutrophil lymphocyte ratio after bcg treatment be a prognostic marker for nmibc |
| topic | non-muscle invasive bladder cancer neutrophil-lymphocyte ratio bcg treatment eortc risk classification progression recurrence |
| url |
http://jurolsurgery.org/archives/archive-detail/article-preview/does-the-decrease-in-neutrophil-lymphocyte-ratio-a/42817
|
| work_keys_str_mv | AT aykutbaser doesthedecreaseinneutrophillymphocyteratioafterbcgtreatmentbeaprognosticmarkerfornmibc |