Paeoniflorin Alleviates Skeletal Muscle Atrophy in Ovariectomized Mice through the ERα/NRF1 Mitochondrial Biogenesis Pathway

Paeoniflorin Alleviates Skeletal Muscle Atrophy in Ovariectomized Mice through the ERα/NRF1 Mitochondrial Biogenesis Pathway

Muscle atrophy in postmenopausal women is caused by estrogen deficiency and a variety of inflammatory factors, including tumor necrosis factor alpha (TNFα). Paeoniflorin (PNF), a natural compound with anti-inflammatory properties, improves estradiol synthesis. Here, we demonstrate that PNF inhibits...

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Bibliographic Details
Main Authors: Ki-Sun Park, Hyungjun Kim, Hye Jin Kim, Kang-In Lee, Seo-Young Lee, Jieun Kim
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Pharmaceuticals
Subjects:
muscle atrophy
post-menopausal women
estrogen insufficiency
paeoniflorin
mitochondrial biogenesis
anti-inflammation
Online Access:https://www.mdpi.com/1424-8247/15/4/390

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