Adaptation to Chronic-Cycling Hypoxia Renders Cancer Cells Resistant to MTH1-Inhibitor Treatment Which Can Be Counteracted by Glutathione Depletion

Adaptation to Chronic-Cycling Hypoxia Renders Cancer Cells Resistant to MTH1-Inhibitor Treatment Which Can Be Counteracted by Glutathione Depletion

Tumor hypoxia and hypoxic adaptation of cancer cells represent major barriers to successful cancer treatment. We revealed that improved antioxidant capacity contributes to increased radioresistance of cancer cells with tolerance to chronic-cycling severe hypoxia/reoxygenation stress. We hypothesized...

Full description

Bibliographic Details
Main Authors: Christine Hansel, Julian Hlouschek, Kexu Xiang, Margarita Melnikova, Juergen Thomale, Thomas Helleday, Verena Jendrossek, Johann Matschke
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Cells
Subjects:
chronic cycling hypoxia
radiation resistance
metabolic reprogramming
antioxidant capacity
redox homeostasis
ionizing radiation
Online Access:https://www.mdpi.com/2073-4409/10/11/3040

Similar Items

Similar Items