The Molecular Mechanisms of Allosteric Mutations Impairing MepR Repressor Function in Multidrug-Resistant Strains of <named-content content-type="genus-species">Staphylococcus aureus</named-content>

The Molecular Mechanisms of Allosteric Mutations Impairing MepR Repressor Function in Multidrug-Resistant Strains of <named-content content-type="genus-species">Staphylococcus aureus</named-content>

ABSTRACT Overexpression of the Staphylococcus aureus multidrug efflux pump MepA confers resistance to a wide variety of antimicrobials. mepA expression is controlled by MarR family member MepR, which represses mepA and autorepresses its own production. Mutations in mepR are a primary cause of mepA o...

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Bibliographic Details
Main Authors: Ivan Birukou, Nam K. Tonthat, Susan M. Seo, Bryan D. Schindler, Glenn W. Kaatz, Richard G. Brennan
Format: Article
Language:English
Published: American Society for Microbiology 2013-11-01
Series:mBio
Online Access:https://journals.asm.org/doi/10.1128/mBio.00528-13

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