Effects of Therapy with Fibrin Glue combined with Mesenchymal Stem Cells (MSCs) on Bone Regeneration: A Systematic Review
Cell therapy strategies using mesenchymal stem cells (MSCs) carried in fibrin glue have shown promising results in regenerative medicine. MSCs are crucial for tissue healing because they have angiogenic, anti-apoptotic and immunomodulatory properties, in addition to the ability to differentiate into...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/9/2323 |
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| author | Adriana de Cássia Ortiz Simone Ortiz Moura Fideles Karina Torres Pomini Carlos Henrique Bertoni Reis Cleuber Rodrigo de Souza Bueno Eliana de Souza Bastos Mazuqueli Pereira Jéssica de Oliveira Rossi Paulo Cezar Novais João Paulo Galletti Pilon Geraldo Marco Rosa Junior Daniela Vieira Buchaim Rogerio Leone Buchaim |
| author_facet | Adriana de Cássia Ortiz Simone Ortiz Moura Fideles Karina Torres Pomini Carlos Henrique Bertoni Reis Cleuber Rodrigo de Souza Bueno Eliana de Souza Bastos Mazuqueli Pereira Jéssica de Oliveira Rossi Paulo Cezar Novais João Paulo Galletti Pilon Geraldo Marco Rosa Junior Daniela Vieira Buchaim Rogerio Leone Buchaim |
| author_sort | Adriana de Cássia Ortiz |
| collection | DOAJ |
| description | Cell therapy strategies using mesenchymal stem cells (MSCs) carried in fibrin glue have shown promising results in regenerative medicine. MSCs are crucial for tissue healing because they have angiogenic, anti-apoptotic and immunomodulatory properties, in addition to the ability to differentiate into several specialized cell lines. Fibrin sealant or fibrin glue is a natural polymer involved in the coagulation process. Fibrin glue provides a temporary structure that favors angiogenesis, extracellular matrix deposition and cell-matrix interactions. Additionally, fibrin glue maintains the local and paracrine functions of MSCs, providing tissue regeneration through less invasive clinical procedures. Thus, the objective of this systematic review was to assess the potential of fibrin glue combined with MSCs in bone or cartilage regeneration. The bibliographic search was performed in the PubMed/MEDLINE, LILACS and Embase databases, using the descriptors (“fibrin sealant” OR “fibrin glue”) AND “stem cells” AND “bone regeneration”, considering articles published until 2021. In this case, 12 preclinical and five clinical studies were selected to compose this review, according to the eligibility criteria. In preclinical studies, fibrin glue loaded with MSCs, alone or associated with bone substitute, significantly favored bone defects regeneration compared to scaffold without cells. Similarly, fibrin glue loaded with MSCs presented considerable potential to regenerate joint cartilage injuries and multiple bone fractures, with significant improvement in clinical parameters and absence of postoperative complications. Therefore, there is clear evidence in the literature that fibrin glue loaded with MSCs, alone or combined with bone substitute, is a promising strategy for treating lesions in bone or cartilaginous tissue. |
| first_indexed | 2024-03-10T07:48:58Z |
| format | Article |
| id | doaj.art-07f7c1fa0a514ea3b8f49f426c39949e |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T07:48:58Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-07f7c1fa0a514ea3b8f49f426c39949e2023-11-22T12:24:17ZengMDPI AGCells2073-44092021-09-01109232310.3390/cells10092323Effects of Therapy with Fibrin Glue combined with Mesenchymal Stem Cells (MSCs) on Bone Regeneration: A Systematic ReviewAdriana de Cássia Ortiz0Simone Ortiz Moura Fideles1Karina Torres Pomini2Carlos Henrique Bertoni Reis3Cleuber Rodrigo de Souza Bueno4Eliana de Souza Bastos Mazuqueli Pereira5Jéssica de Oliveira Rossi6Paulo Cezar Novais7João Paulo Galletti Pilon8Geraldo Marco Rosa Junior9Daniela Vieira Buchaim10Rogerio Leone Buchaim11Department of Biological Sciences, Bauru School of Dentistry (FOB/USP), University of São Paulo, Bauru 17012-901, SP, BrazilDepartment of Biological Sciences, Bauru School of Dentistry (FOB/USP), University of São Paulo, Bauru 17012-901, SP, BrazilDepartment of Biological Sciences, Bauru School of Dentistry (FOB/USP), University of São Paulo, Bauru 17012-901, SP, BrazilDepartment of Biological Sciences, Bauru School of Dentistry (FOB/USP), University of São Paulo, Bauru 17012-901, SP, BrazilDepartment of Biological Sciences, Bauru School of Dentistry (FOB/USP), University of São Paulo, Bauru 17012-901, SP, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, Postgraduate Department, University of Marilia (UNIMAR), Marília 17525-902, SP, BrazilDepartment of Biological Sciences, Bauru School of Dentistry (FOB/USP), University of São Paulo, Bauru 17012-901, SP, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, Postgraduate Department, University of Marilia (UNIMAR), Marília 17525-902, SP, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, Postgraduate Department, University of Marilia (UNIMAR), Marília 17525-902, SP, BrazilPro-rectory of Graduate Studies and Research, Sacred Heart University Center (UNISAGRADO), Bauru 17011-160, SP, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, Postgraduate Department, University of Marilia (UNIMAR), Marília 17525-902, SP, BrazilDepartment of Biological Sciences, Bauru School of Dentistry (FOB/USP), University of São Paulo, Bauru 17012-901, SP, BrazilCell therapy strategies using mesenchymal stem cells (MSCs) carried in fibrin glue have shown promising results in regenerative medicine. MSCs are crucial for tissue healing because they have angiogenic, anti-apoptotic and immunomodulatory properties, in addition to the ability to differentiate into several specialized cell lines. Fibrin sealant or fibrin glue is a natural polymer involved in the coagulation process. Fibrin glue provides a temporary structure that favors angiogenesis, extracellular matrix deposition and cell-matrix interactions. Additionally, fibrin glue maintains the local and paracrine functions of MSCs, providing tissue regeneration through less invasive clinical procedures. Thus, the objective of this systematic review was to assess the potential of fibrin glue combined with MSCs in bone or cartilage regeneration. The bibliographic search was performed in the PubMed/MEDLINE, LILACS and Embase databases, using the descriptors (“fibrin sealant” OR “fibrin glue”) AND “stem cells” AND “bone regeneration”, considering articles published until 2021. In this case, 12 preclinical and five clinical studies were selected to compose this review, according to the eligibility criteria. In preclinical studies, fibrin glue loaded with MSCs, alone or associated with bone substitute, significantly favored bone defects regeneration compared to scaffold without cells. Similarly, fibrin glue loaded with MSCs presented considerable potential to regenerate joint cartilage injuries and multiple bone fractures, with significant improvement in clinical parameters and absence of postoperative complications. Therefore, there is clear evidence in the literature that fibrin glue loaded with MSCs, alone or combined with bone substitute, is a promising strategy for treating lesions in bone or cartilaginous tissue.https://www.mdpi.com/2073-4409/10/9/2323bone regenerationbone repairfibrin gluefibrin sealantscaffoldsstem cells |
| spellingShingle | Adriana de Cássia Ortiz Simone Ortiz Moura Fideles Karina Torres Pomini Carlos Henrique Bertoni Reis Cleuber Rodrigo de Souza Bueno Eliana de Souza Bastos Mazuqueli Pereira Jéssica de Oliveira Rossi Paulo Cezar Novais João Paulo Galletti Pilon Geraldo Marco Rosa Junior Daniela Vieira Buchaim Rogerio Leone Buchaim Effects of Therapy with Fibrin Glue combined with Mesenchymal Stem Cells (MSCs) on Bone Regeneration: A Systematic Review Cells bone regeneration bone repair fibrin glue fibrin sealant scaffolds stem cells |
| title | Effects of Therapy with Fibrin Glue combined with Mesenchymal Stem Cells (MSCs) on Bone Regeneration: A Systematic Review |
| title_full | Effects of Therapy with Fibrin Glue combined with Mesenchymal Stem Cells (MSCs) on Bone Regeneration: A Systematic Review |
| title_fullStr | Effects of Therapy with Fibrin Glue combined with Mesenchymal Stem Cells (MSCs) on Bone Regeneration: A Systematic Review |
| title_full_unstemmed | Effects of Therapy with Fibrin Glue combined with Mesenchymal Stem Cells (MSCs) on Bone Regeneration: A Systematic Review |
| title_short | Effects of Therapy with Fibrin Glue combined with Mesenchymal Stem Cells (MSCs) on Bone Regeneration: A Systematic Review |
| title_sort | effects of therapy with fibrin glue combined with mesenchymal stem cells mscs on bone regeneration a systematic review |
| topic | bone regeneration bone repair fibrin glue fibrin sealant scaffolds stem cells |
| url | https://www.mdpi.com/2073-4409/10/9/2323 |
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