Application of Texture Analysis to Study Small Vessel Disease and Blood–Brain Barrier Integrity
ObjectivesWe evaluate the alternative use of texture analysis for evaluating the role of blood–brain barrier (BBB) in small vessel disease (SVD).MethodsWe used brain magnetic resonance imaging from 204 stroke patients, acquired before and 20 min after intravenous gadolinium administration. We segmen...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-07-01
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| Series: | Frontiers in Neurology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fneur.2017.00327/full |
| _version_ | 1828377817098747904 |
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| author | Maria del C. Valdés Hernández Victor González-Castro Francesca M. Chappell Eleni Sakka Stephen Makin Paul A. Armitage William H. Nailon Joanna M. Wardlaw |
| author_facet | Maria del C. Valdés Hernández Victor González-Castro Francesca M. Chappell Eleni Sakka Stephen Makin Paul A. Armitage William H. Nailon Joanna M. Wardlaw |
| author_sort | Maria del C. Valdés Hernández |
| collection | DOAJ |
| description | ObjectivesWe evaluate the alternative use of texture analysis for evaluating the role of blood–brain barrier (BBB) in small vessel disease (SVD).MethodsWe used brain magnetic resonance imaging from 204 stroke patients, acquired before and 20 min after intravenous gadolinium administration. We segmented tissues, white matter hyperintensities (WMH) and applied validated visual scores. We measured textural features in all tissues pre- and post-contrast and used ANCOVA to evaluate the effect of SVD indicators on the pre-/post-contrast change, Kruskal–Wallis for significance between patient groups and linear mixed models for pre-/post-contrast variations in cerebrospinal fluid (CSF) with Fazekas scores.ResultsTextural “homogeneity” increase in normal tissues with higher presence of SVD indicators was consistently more overt than in abnormal tissues. Textural “homogeneity” increased with age, basal ganglia perivascular spaces scores (p < 0.01) and SVD scores (p < 0.05) and was significantly higher in hypertensive patients (p < 0.002) and lacunar stroke (p = 0.04). Hypertension (74% patients), WMH load (median = 1.5 ± 1.6% of intracranial volume), and age (mean = 65.6 years, SD = 11.3) predicted the pre/post-contrast change in normal white matter, WMH, and index stroke lesion. CSF signal increased with increasing SVD post-contrast.ConclusionA consistent general pattern of increasing textural “homogeneity” with increasing SVD and post-contrast change in CSF with increasing WMH suggest that texture analysis may be useful for the study of BBB integrity. |
| first_indexed | 2024-04-14T08:17:58Z |
| format | Article |
| id | doaj.art-07f8a20698834efa936537238ddb9b86 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-14T08:17:58Z |
| publishDate | 2017-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-07f8a20698834efa936537238ddb9b862022-12-22T02:04:19ZengFrontiers Media S.A.Frontiers in Neurology1664-22952017-07-01810.3389/fneur.2017.00327269807Application of Texture Analysis to Study Small Vessel Disease and Blood–Brain Barrier IntegrityMaria del C. Valdés Hernández0Victor González-Castro1Francesca M. Chappell2Eleni Sakka3Stephen Makin4Paul A. Armitage5William H. Nailon6Joanna M. Wardlaw7Department of Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United KingdomDepartment of Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United KingdomDepartment of Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United KingdomDepartment of Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United KingdomDepartment of Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United KingdomDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United KingdomDepartment of Oncology Physics, University of Edinburgh, Edinburgh, United KingdomDepartment of Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United KingdomObjectivesWe evaluate the alternative use of texture analysis for evaluating the role of blood–brain barrier (BBB) in small vessel disease (SVD).MethodsWe used brain magnetic resonance imaging from 204 stroke patients, acquired before and 20 min after intravenous gadolinium administration. We segmented tissues, white matter hyperintensities (WMH) and applied validated visual scores. We measured textural features in all tissues pre- and post-contrast and used ANCOVA to evaluate the effect of SVD indicators on the pre-/post-contrast change, Kruskal–Wallis for significance between patient groups and linear mixed models for pre-/post-contrast variations in cerebrospinal fluid (CSF) with Fazekas scores.ResultsTextural “homogeneity” increase in normal tissues with higher presence of SVD indicators was consistently more overt than in abnormal tissues. Textural “homogeneity” increased with age, basal ganglia perivascular spaces scores (p < 0.01) and SVD scores (p < 0.05) and was significantly higher in hypertensive patients (p < 0.002) and lacunar stroke (p = 0.04). Hypertension (74% patients), WMH load (median = 1.5 ± 1.6% of intracranial volume), and age (mean = 65.6 years, SD = 11.3) predicted the pre/post-contrast change in normal white matter, WMH, and index stroke lesion. CSF signal increased with increasing SVD post-contrast.ConclusionA consistent general pattern of increasing textural “homogeneity” with increasing SVD and post-contrast change in CSF with increasing WMH suggest that texture analysis may be useful for the study of BBB integrity.http://journal.frontiersin.org/article/10.3389/fneur.2017.00327/fulltexture analysiscerebral small vessel diseaseblood–brain barrierhypertensionagestroke |
| spellingShingle | Maria del C. Valdés Hernández Victor González-Castro Francesca M. Chappell Eleni Sakka Stephen Makin Paul A. Armitage William H. Nailon Joanna M. Wardlaw Application of Texture Analysis to Study Small Vessel Disease and Blood–Brain Barrier Integrity Frontiers in Neurology texture analysis cerebral small vessel disease blood–brain barrier hypertension age stroke |
| title | Application of Texture Analysis to Study Small Vessel Disease and Blood–Brain Barrier Integrity |
| title_full | Application of Texture Analysis to Study Small Vessel Disease and Blood–Brain Barrier Integrity |
| title_fullStr | Application of Texture Analysis to Study Small Vessel Disease and Blood–Brain Barrier Integrity |
| title_full_unstemmed | Application of Texture Analysis to Study Small Vessel Disease and Blood–Brain Barrier Integrity |
| title_short | Application of Texture Analysis to Study Small Vessel Disease and Blood–Brain Barrier Integrity |
| title_sort | application of texture analysis to study small vessel disease and blood brain barrier integrity |
| topic | texture analysis cerebral small vessel disease blood–brain barrier hypertension age stroke |
| url | http://journal.frontiersin.org/article/10.3389/fneur.2017.00327/full |
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