Tunable, Low–Cost, Multi–Channel, Broadband Liquid Crystal Shutter for Fluorescence Imaging in Widefield Microscopy
Bistable liquid crystal (LC) shutters have attracted much interest due to their low energy consumption and fast response time. In this paper, we demonstrate an electrically tunable/switchable biostable LC light shutter in biological optics through a three–step easy–assembly, inexpensive, multi–chann...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-08-01
|
| Series: | Micromachines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-666X/13/8/1310 |
| _version_ | 1797443336370388992 |
|---|---|
| author | Yan Gong Bo Li Cheng-You Yao Weiyang Yang Qi Hua Fan Zhen Qiu Wen Li |
| author_facet | Yan Gong Bo Li Cheng-You Yao Weiyang Yang Qi Hua Fan Zhen Qiu Wen Li |
| author_sort | Yan Gong |
| collection | DOAJ |
| description | Bistable liquid crystal (LC) shutters have attracted much interest due to their low energy consumption and fast response time. In this paper, we demonstrate an electrically tunable/switchable biostable LC light shutter in biological optics through a three–step easy–assembly, inexpensive, multi–channel shutter. The liquid crystal exhibits tunable transparency (100% to 10% compared to the initial light intensity) under different voltages (0 V to 90 V), indicating its tunable potential. By using biomedical images, the response time, resolution, and light intensity changes of the LC under different voltages in three common fluorescence wavelengths are displayed intuitively. Particularly, the shutter’s performance in tumor images under the near–infrared band shows its application potential in biomedical imaging fields. |
| first_indexed | 2024-03-09T12:55:32Z |
| format | Article |
| id | doaj.art-07f9b966b89d44d69d09e16f608e42d7 |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-09T12:55:32Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-07f9b966b89d44d69d09e16f608e42d72023-11-30T22:00:46ZengMDPI AGMicromachines2072-666X2022-08-01138131010.3390/mi13081310Tunable, Low–Cost, Multi–Channel, Broadband Liquid Crystal Shutter for Fluorescence Imaging in Widefield MicroscopyYan Gong0Bo Li1Cheng-You Yao2Weiyang Yang3Qi Hua Fan4Zhen Qiu5Wen Li6Electrical and Computer Engineering Department, Michigan State University, 428 S Shaw Ln, #2120, East Lansing, MI 48824, USAElectrical and Computer Engineering Department, Michigan State University, 428 S Shaw Ln, #2120, East Lansing, MI 48824, USABiomedical Engineering Department, Michigan State University, 775 Woodlot Dr, East Lansing, MI 48824, USAElectrical and Computer Engineering Department, Michigan State University, 428 S Shaw Ln, #2120, East Lansing, MI 48824, USAElectrical and Computer Engineering Department, Michigan State University, 428 S Shaw Ln, #2120, East Lansing, MI 48824, USABiomedical Engineering Department, Michigan State University, 775 Woodlot Dr, East Lansing, MI 48824, USAElectrical and Computer Engineering Department, Michigan State University, 428 S Shaw Ln, #2120, East Lansing, MI 48824, USABistable liquid crystal (LC) shutters have attracted much interest due to their low energy consumption and fast response time. In this paper, we demonstrate an electrically tunable/switchable biostable LC light shutter in biological optics through a three–step easy–assembly, inexpensive, multi–channel shutter. The liquid crystal exhibits tunable transparency (100% to 10% compared to the initial light intensity) under different voltages (0 V to 90 V), indicating its tunable potential. By using biomedical images, the response time, resolution, and light intensity changes of the LC under different voltages in three common fluorescence wavelengths are displayed intuitively. Particularly, the shutter’s performance in tumor images under the near–infrared band shows its application potential in biomedical imaging fields.https://www.mdpi.com/2072-666X/13/8/1310liquid crystal shutternematic liquid crystalfluorescence imagingtumor imagingbroadband |
| spellingShingle | Yan Gong Bo Li Cheng-You Yao Weiyang Yang Qi Hua Fan Zhen Qiu Wen Li Tunable, Low–Cost, Multi–Channel, Broadband Liquid Crystal Shutter for Fluorescence Imaging in Widefield Microscopy Micromachines liquid crystal shutter nematic liquid crystal fluorescence imaging tumor imaging broadband |
| title | Tunable, Low–Cost, Multi–Channel, Broadband Liquid Crystal Shutter for Fluorescence Imaging in Widefield Microscopy |
| title_full | Tunable, Low–Cost, Multi–Channel, Broadband Liquid Crystal Shutter for Fluorescence Imaging in Widefield Microscopy |
| title_fullStr | Tunable, Low–Cost, Multi–Channel, Broadband Liquid Crystal Shutter for Fluorescence Imaging in Widefield Microscopy |
| title_full_unstemmed | Tunable, Low–Cost, Multi–Channel, Broadband Liquid Crystal Shutter for Fluorescence Imaging in Widefield Microscopy |
| title_short | Tunable, Low–Cost, Multi–Channel, Broadband Liquid Crystal Shutter for Fluorescence Imaging in Widefield Microscopy |
| title_sort | tunable low cost multi channel broadband liquid crystal shutter for fluorescence imaging in widefield microscopy |
| topic | liquid crystal shutter nematic liquid crystal fluorescence imaging tumor imaging broadband |
| url | https://www.mdpi.com/2072-666X/13/8/1310 |
| work_keys_str_mv | AT yangong tunablelowcostmultichannelbroadbandliquidcrystalshutterforfluorescenceimaginginwidefieldmicroscopy AT boli tunablelowcostmultichannelbroadbandliquidcrystalshutterforfluorescenceimaginginwidefieldmicroscopy AT chengyouyao tunablelowcostmultichannelbroadbandliquidcrystalshutterforfluorescenceimaginginwidefieldmicroscopy AT weiyangyang tunablelowcostmultichannelbroadbandliquidcrystalshutterforfluorescenceimaginginwidefieldmicroscopy AT qihuafan tunablelowcostmultichannelbroadbandliquidcrystalshutterforfluorescenceimaginginwidefieldmicroscopy AT zhenqiu tunablelowcostmultichannelbroadbandliquidcrystalshutterforfluorescenceimaginginwidefieldmicroscopy AT wenli tunablelowcostmultichannelbroadbandliquidcrystalshutterforfluorescenceimaginginwidefieldmicroscopy |