Obesity and lung cancer – is programmed death ligand-1 (PD-1L) expression a connection?
Introduction In this retrospective study, the authors evaluated whether obesity-induced immunomodulation impacts the expression of programmed death ligand-1 (PD-1L) in lung cancer cells. Methods A retrospective cross-sectional study was performed. The study included 67 patients. The data did not ha...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2024-01-01
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| Series: | Archives of Medical Science |
| Subjects: | |
| Online Access: | https://www.archivesofmedicalscience.com/Obesity-and-lung-cancer-is-programmed-death-ligand-1-PD-1L-expression-a-connection,175470,0,2.html |
| _version_ | 1827287670083026944 |
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| author | Jakub Krzysztof Gałązka Marcin Czeczelewski Tomasz Kucharczyk Katarzyna Szklener Sławomir Mańdziuk |
| author_facet | Jakub Krzysztof Gałązka Marcin Czeczelewski Tomasz Kucharczyk Katarzyna Szklener Sławomir Mańdziuk |
| author_sort | Jakub Krzysztof Gałązka |
| collection | DOAJ |
| description | Introduction
In this retrospective study, the authors evaluated whether obesity-induced immunomodulation impacts the expression of programmed death ligand-1 (PD-1L) in lung cancer cells.
Methods
A retrospective cross-sectional study was performed. The study included 67 patients. The data did not have a normal distribution.
Results
For women, using ANOVA test (p = 0.050) with post-hoc analysis, a statistically significant difference in expression was found between women with overweight and women with normal weight (p = 0.040).
Conclusions
Apart from the above, the authors did not find any statistically significant correlation between PD-1L expression on lung cancer cells and body mass index, either in the whole group or in histological subgroups. |
| first_indexed | 2024-04-24T11:15:39Z |
| format | Article |
| id | doaj.art-07fa8573e210490ca4b01c539996580e |
| institution | Directory Open Access Journal |
| issn | 1734-1922 1896-9151 |
| language | English |
| last_indexed | 2024-04-24T11:15:39Z |
| publishDate | 2024-01-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj.art-07fa8573e210490ca4b01c539996580e2024-04-11T08:11:16ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512024-01-0120131331610.5114/aoms/175470175470Obesity and lung cancer – is programmed death ligand-1 (PD-1L) expression a connection?Jakub Krzysztof Gałązka0https://orcid.org/0000-0003-3128-773XMarcin Czeczelewski1https://orcid.org/0000-0002-5576-4169Tomasz Kucharczyk2https://orcid.org/0000-0002-2678-8655Katarzyna Szklener3https://orcid.org/0000-0001-8033-3574Sławomir Mańdziuk4https://orcid.org/0000-0002-9812-0777Students’ Scientific Association at Chair of Clinical Oncology and Chemotherapy, Medical University of Lublin, Lublin, PolandStudents’ Scientific Association at Department and Clinic of Interventional Radiology and Neuroradiology, Medical University of Lublin, Lublin, PolandLaboratory for Immunology and Genetics, Medical University of Lublin, Lublin, PolandChair of Clinical Oncology and Chemotherapy, Medical University of Lublin, Lublin, PolandChair of Clinical Oncology and Chemotherapy, Medical University of Lublin, Lublin, PolandIntroduction In this retrospective study, the authors evaluated whether obesity-induced immunomodulation impacts the expression of programmed death ligand-1 (PD-1L) in lung cancer cells. Methods A retrospective cross-sectional study was performed. The study included 67 patients. The data did not have a normal distribution. Results For women, using ANOVA test (p = 0.050) with post-hoc analysis, a statistically significant difference in expression was found between women with overweight and women with normal weight (p = 0.040). Conclusions Apart from the above, the authors did not find any statistically significant correlation between PD-1L expression on lung cancer cells and body mass index, either in the whole group or in histological subgroups.https://www.archivesofmedicalscience.com/Obesity-and-lung-cancer-is-programmed-death-ligand-1-PD-1L-expression-a-connection,175470,0,2.htmlprogrammed death ligand-1lung cancerobesityoncologypulmonologyobesitology |
| spellingShingle | Jakub Krzysztof Gałązka Marcin Czeczelewski Tomasz Kucharczyk Katarzyna Szklener Sławomir Mańdziuk Obesity and lung cancer – is programmed death ligand-1 (PD-1L) expression a connection? Archives of Medical Science programmed death ligand-1 lung cancer obesity oncology pulmonology obesitology |
| title | Obesity and lung cancer – is programmed death ligand-1 (PD-1L) expression a connection? |
| title_full | Obesity and lung cancer – is programmed death ligand-1 (PD-1L) expression a connection? |
| title_fullStr | Obesity and lung cancer – is programmed death ligand-1 (PD-1L) expression a connection? |
| title_full_unstemmed | Obesity and lung cancer – is programmed death ligand-1 (PD-1L) expression a connection? |
| title_short | Obesity and lung cancer – is programmed death ligand-1 (PD-1L) expression a connection? |
| title_sort | obesity and lung cancer is programmed death ligand 1 pd 1l expression a connection |
| topic | programmed death ligand-1 lung cancer obesity oncology pulmonology obesitology |
| url | https://www.archivesofmedicalscience.com/Obesity-and-lung-cancer-is-programmed-death-ligand-1-PD-1L-expression-a-connection,175470,0,2.html |
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