Single-cell transcriptome atlas of the human corpus cavernosum

The corpus cavernosum is the most important structure for penile erection, and its dysfunction causes physiological and psychological problems. Here the authors perform single-cell RNA-sequencing on corpus cavernosum samples from males with normal erection and erectile dysfunction patients, providin...

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Main Authors: LiangYu Zhao, Sha Han, HengChuan Su, JianYing Li, ErLei Zhi, Peng Li, ChenCheng Yao, RuHui Tian, HuiXing Chen, HuiRong Chen, JiaQiang Luo, ChenKun Shi, ZhiYong Ji, JianLin Hu, Gang Wu, WeiDong Zhou, YuXin Tang, YuZhuo Chen, GuiTing Lin, Tom F. Lue, DengLong Wu, Zheng Li
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-31950-9
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author LiangYu Zhao
Sha Han
HengChuan Su
JianYing Li
ErLei Zhi
Peng Li
ChenCheng Yao
RuHui Tian
HuiXing Chen
HuiRong Chen
JiaQiang Luo
ChenKun Shi
ZhiYong Ji
JianLin Hu
Gang Wu
WeiDong Zhou
YuXin Tang
YuZhuo Chen
GuiTing Lin
Tom F. Lue
DengLong Wu
Zheng Li
author_facet LiangYu Zhao
Sha Han
HengChuan Su
JianYing Li
ErLei Zhi
Peng Li
ChenCheng Yao
RuHui Tian
HuiXing Chen
HuiRong Chen
JiaQiang Luo
ChenKun Shi
ZhiYong Ji
JianLin Hu
Gang Wu
WeiDong Zhou
YuXin Tang
YuZhuo Chen
GuiTing Lin
Tom F. Lue
DengLong Wu
Zheng Li
author_sort LiangYu Zhao
collection DOAJ
description The corpus cavernosum is the most important structure for penile erection, and its dysfunction causes physiological and psychological problems. Here the authors perform single-cell RNA-sequencing on corpus cavernosum samples from males with normal erection and erectile dysfunction patients, providing insights into this pathology.
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spelling doaj.art-07fafce296174665a0ff8b6b174ec9912022-12-22T03:40:27ZengNature PortfolioNature Communications2041-17232022-07-0113111610.1038/s41467-022-31950-9Single-cell transcriptome atlas of the human corpus cavernosumLiangYu Zhao0Sha Han1HengChuan Su2JianYing Li3ErLei Zhi4Peng Li5ChenCheng Yao6RuHui Tian7HuiXing Chen8HuiRong Chen9JiaQiang Luo10ChenKun Shi11ZhiYong Ji12JianLin Hu13Gang Wu14WeiDong Zhou15YuXin Tang16YuZhuo Chen17GuiTing Lin18Tom F. Lue19DengLong Wu20Zheng Li21Department of Andrology, the Center for Men’s Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Andrology, the Center for Men’s Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Urology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan UniversityDepartment of Andrology, the Center for Men’s Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Andrology, the Center for Men’s Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Andrology, the Center for Men’s Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Andrology, the Center for Men’s Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Andrology, the Center for Men’s Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Andrology, the Center for Men’s Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Andrology, the Center for Men’s Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Andrology, the Center for Men’s Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Andrology, the Center for Men’s Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Andrology, the Center for Men’s Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Andrology, the Center for Men’s Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Urology, Tongji Hospital, School of Medicine, Tongji UniversityDepartment of Urology, Tongji Hospital, School of Medicine, Tongji UniversityDepartment of Urology, Department of Interventional Medicine, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen UniversityDepartment of Ultrasound, The Fifth Affiliated Hospital, Sun Yat-sen UniversityKnuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of CaliforniaKnuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of CaliforniaDepartment of Urology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan UniversityDepartment of Andrology, the Center for Men’s Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineThe corpus cavernosum is the most important structure for penile erection, and its dysfunction causes physiological and psychological problems. Here the authors perform single-cell RNA-sequencing on corpus cavernosum samples from males with normal erection and erectile dysfunction patients, providing insights into this pathology.https://doi.org/10.1038/s41467-022-31950-9
spellingShingle LiangYu Zhao
Sha Han
HengChuan Su
JianYing Li
ErLei Zhi
Peng Li
ChenCheng Yao
RuHui Tian
HuiXing Chen
HuiRong Chen
JiaQiang Luo
ChenKun Shi
ZhiYong Ji
JianLin Hu
Gang Wu
WeiDong Zhou
YuXin Tang
YuZhuo Chen
GuiTing Lin
Tom F. Lue
DengLong Wu
Zheng Li
Single-cell transcriptome atlas of the human corpus cavernosum
Nature Communications
title Single-cell transcriptome atlas of the human corpus cavernosum
title_full Single-cell transcriptome atlas of the human corpus cavernosum
title_fullStr Single-cell transcriptome atlas of the human corpus cavernosum
title_full_unstemmed Single-cell transcriptome atlas of the human corpus cavernosum
title_short Single-cell transcriptome atlas of the human corpus cavernosum
title_sort single cell transcriptome atlas of the human corpus cavernosum
url https://doi.org/10.1038/s41467-022-31950-9
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