No causal genetic relationships between atrial fibrillation and vascular dementia: A bidirectional Mendelian randomization study
BackgroundNumerous observational studies have suggested that atrial fibrillation (AF) was associated with an increased risk of vascular dementia (VaD). However, the causal genetic relationships between AF and VaD remains unclear. To evaluate the effect of AF on VaD, we performed the Mendelian random...
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1071574/full |
| _version_ | 1797791282584616960 |
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| author | Ya-fang Gao Ya-fang Gao Tian-yu Jin Tian-yu Jin Yan Chen Ya-hui Ding |
| author_facet | Ya-fang Gao Ya-fang Gao Tian-yu Jin Tian-yu Jin Yan Chen Ya-hui Ding |
| author_sort | Ya-fang Gao |
| collection | DOAJ |
| description | BackgroundNumerous observational studies have suggested that atrial fibrillation (AF) was associated with an increased risk of vascular dementia (VaD). However, the causal genetic relationships between AF and VaD remains unclear. To evaluate the effect of AF on VaD, we performed the Mendelian randomization (MR) analysis to investigate the causal genetic relationships between AF and VaD.MethodsThe bidirectional MR analysis was conducted to explore the causal relationships between exposure and disease. We applied a series of quality assessments to select significantly and independently single nucleotide polymorphisms (SNPs) from publicly available large-scale genome-wide association studies (GWAS) databases. Three methods [Inverse variance weighted method (IVW), MR-Egger method, and weighted median (WM)method] were used to derive MR estimates. In order to ensure reliable MR results, sensitivity analyses were performed to evaluate the horizontal pleiotropy and heterogeneity.ResultsOur MR analyses revealed no significant genetic relationships between AF and the risk of VaD (IVW: OR = 1.10, 95%CI = 0.95–1.28, P = 0.20). In the reverse direction analysis, there was no evidence to support a significant genetic relationship of VaD with AF risk (IVW: OR = 1.00, 95% CI = 0.99–1.01, P = 0.52). Consistent results were obtained using different MR methods. Sensitivity analyses suggested no significant horizontal pleiotropy and heterogeneity in the study.ConclusionThis MR analysis did not provide evidence to support the causal genetic relationships between AF on VaD risk and the causal effect of VaD on AF risk. |
| first_indexed | 2024-03-13T02:16:37Z |
| format | Article |
| id | doaj.art-07fb61c6daac4550ac8f8a1988af19ed |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-13T02:16:37Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-07fb61c6daac4550ac8f8a1988af19ed2023-06-30T12:00:13ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-06-011010.3389/fcvm.2023.10715741071574No causal genetic relationships between atrial fibrillation and vascular dementia: A bidirectional Mendelian randomization studyYa-fang Gao0Ya-fang Gao1Tian-yu Jin2Tian-yu Jin3Yan Chen4Ya-hui Ding5Department of Cardiology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, ChinaHeart Center, Department of Cardiovascular Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, ChinaHeart Center, Department of Cardiovascular Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, ChinaDepartment of Rehabilitation Medicine, Wenzhou Medical University, Wenzhou, ChinaHeart Center, Department of Cardiovascular Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, ChinaHeart Center, Department of Cardiovascular Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, ChinaBackgroundNumerous observational studies have suggested that atrial fibrillation (AF) was associated with an increased risk of vascular dementia (VaD). However, the causal genetic relationships between AF and VaD remains unclear. To evaluate the effect of AF on VaD, we performed the Mendelian randomization (MR) analysis to investigate the causal genetic relationships between AF and VaD.MethodsThe bidirectional MR analysis was conducted to explore the causal relationships between exposure and disease. We applied a series of quality assessments to select significantly and independently single nucleotide polymorphisms (SNPs) from publicly available large-scale genome-wide association studies (GWAS) databases. Three methods [Inverse variance weighted method (IVW), MR-Egger method, and weighted median (WM)method] were used to derive MR estimates. In order to ensure reliable MR results, sensitivity analyses were performed to evaluate the horizontal pleiotropy and heterogeneity.ResultsOur MR analyses revealed no significant genetic relationships between AF and the risk of VaD (IVW: OR = 1.10, 95%CI = 0.95–1.28, P = 0.20). In the reverse direction analysis, there was no evidence to support a significant genetic relationship of VaD with AF risk (IVW: OR = 1.00, 95% CI = 0.99–1.01, P = 0.52). Consistent results were obtained using different MR methods. Sensitivity analyses suggested no significant horizontal pleiotropy and heterogeneity in the study.ConclusionThis MR analysis did not provide evidence to support the causal genetic relationships between AF on VaD risk and the causal effect of VaD on AF risk.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1071574/fullatrial fibrillationvascular dementiacausalityMendelian randomizationrisk |
| spellingShingle | Ya-fang Gao Ya-fang Gao Tian-yu Jin Tian-yu Jin Yan Chen Ya-hui Ding No causal genetic relationships between atrial fibrillation and vascular dementia: A bidirectional Mendelian randomization study Frontiers in Cardiovascular Medicine atrial fibrillation vascular dementia causality Mendelian randomization risk |
| title | No causal genetic relationships between atrial fibrillation and vascular dementia: A bidirectional Mendelian randomization study |
| title_full | No causal genetic relationships between atrial fibrillation and vascular dementia: A bidirectional Mendelian randomization study |
| title_fullStr | No causal genetic relationships between atrial fibrillation and vascular dementia: A bidirectional Mendelian randomization study |
| title_full_unstemmed | No causal genetic relationships between atrial fibrillation and vascular dementia: A bidirectional Mendelian randomization study |
| title_short | No causal genetic relationships between atrial fibrillation and vascular dementia: A bidirectional Mendelian randomization study |
| title_sort | no causal genetic relationships between atrial fibrillation and vascular dementia a bidirectional mendelian randomization study |
| topic | atrial fibrillation vascular dementia causality Mendelian randomization risk |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1071574/full |
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