Allergic bronchopulmonary aspergillosis in two patients with cystic fibrosis
Allergic bronchopulmonary aspergillosis (ABPA) is hypersensitivity to Aspergillus fumigatus which manifests as episodic wheezing, usually refractory to bronchodilator therapy, with fixed and transient pulmonary infiltrates, central bronchiectasis, blood eosinophilia, elevated serum IgE level,...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2000-01-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/3104 |
| _version_ | 1826543646342643712 |
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| author | D Anadol U Ozçelik N Kiper A Göçmen |
| author_facet | D Anadol U Ozçelik N Kiper A Göçmen |
| author_sort | D Anadol |
| collection | DOAJ |
| description |
Allergic bronchopulmonary aspergillosis (ABPA) is hypersensitivity to Aspergillus fumigatus which manifests as episodic wheezing, usually refractory to bronchodilator therapy, with fixed and transient pulmonary infiltrates, central bronchiectasis, blood eosinophilia, elevated serum IgE level, immediate skin reactivity to an A. fumigatus antigen and precipitating antibodies to A. fumigatus. It is an unusual complication of asthma and cystic fibrosis (CF). We present two cystic fibrosis patients with ABPA treated successfully with prednisone and, in Case 1 also with itraconazole. The physician should be alert to the possibility of ABPA whenever CF patients present with the new infiltrates, high serum total IgE and other positive parameters of A. fumigatus sensitization. Treatment with systemic steroids should be started in order to prevent irreversible lung damage.
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| first_indexed | 2025-03-14T04:49:23Z |
| format | Article |
| id | doaj.art-07fd0890b8664e0f97df81b72b20802d |
| institution | Directory Open Access Journal |
| issn | 0041-4301 2791-6421 |
| language | English |
| last_indexed | 2025-03-14T04:49:23Z |
| publishDate | 2000-01-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj.art-07fd0890b8664e0f97df81b72b20802d2025-03-07T19:43:54ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212000-01-01421Allergic bronchopulmonary aspergillosis in two patients with cystic fibrosisD Anadol0U OzçelikN KiperA GöçmenDepartment of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey. Allergic bronchopulmonary aspergillosis (ABPA) is hypersensitivity to Aspergillus fumigatus which manifests as episodic wheezing, usually refractory to bronchodilator therapy, with fixed and transient pulmonary infiltrates, central bronchiectasis, blood eosinophilia, elevated serum IgE level, immediate skin reactivity to an A. fumigatus antigen and precipitating antibodies to A. fumigatus. It is an unusual complication of asthma and cystic fibrosis (CF). We present two cystic fibrosis patients with ABPA treated successfully with prednisone and, in Case 1 also with itraconazole. The physician should be alert to the possibility of ABPA whenever CF patients present with the new infiltrates, high serum total IgE and other positive parameters of A. fumigatus sensitization. Treatment with systemic steroids should be started in order to prevent irreversible lung damage. https://turkjpediatr.org/article/view/3104 |
| spellingShingle | D Anadol U Ozçelik N Kiper A Göçmen Allergic bronchopulmonary aspergillosis in two patients with cystic fibrosis The Turkish Journal of Pediatrics |
| title | Allergic bronchopulmonary aspergillosis in two patients with cystic fibrosis |
| title_full | Allergic bronchopulmonary aspergillosis in two patients with cystic fibrosis |
| title_fullStr | Allergic bronchopulmonary aspergillosis in two patients with cystic fibrosis |
| title_full_unstemmed | Allergic bronchopulmonary aspergillosis in two patients with cystic fibrosis |
| title_short | Allergic bronchopulmonary aspergillosis in two patients with cystic fibrosis |
| title_sort | allergic bronchopulmonary aspergillosis in two patients with cystic fibrosis |
| url | https://turkjpediatr.org/article/view/3104 |
| work_keys_str_mv | AT danadol allergicbronchopulmonaryaspergillosisintwopatientswithcysticfibrosis AT uozcelik allergicbronchopulmonaryaspergillosisintwopatientswithcysticfibrosis AT nkiper allergicbronchopulmonaryaspergillosisintwopatientswithcysticfibrosis AT agocmen allergicbronchopulmonaryaspergillosisintwopatientswithcysticfibrosis |