Discovery of molecular mechanisms of lignan justicidin A using L1000 gene expression profiles and the Library of Integrated Network-based Cellular Signatures database

Discovery of molecular mechanisms of lignan justicidin A using L1000 gene expression profiles and the Library of Integrated Network-based Cellular Signatures database

Justicidin A (JA), a novel arylnaphthalide lignan, was previously found to reduce the growth of human hepatocellular carcinoma cells (HCC), Hep 3B cells, in NOD-SCID mice via induction of apoptosis. Here, using L1000 microarray profiling obtained from JA-treated HCC cells, the z-score signatures of...

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Bibliographic Details
Main Authors: Shen-Jeu Won, Hsing-Chih Wu, Kuan-Ting Lin, Cheng-Hao Yu, Yi-Ting Chen, Chi-Shiuan Wu, Chi-Ying F. Huang, Hsiao-Sheng Liu, Chun-Nan Lin, Chun-Li Su
Format: Article
Language:English
Published: Elsevier 2015-06-01
Series:Journal of Functional Foods
Subjects:
L1000 gene expression profiling
Library of Integrated Network-based Cellular Signatures
Justicidin A
Autophagy
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S175646461500198X

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