The impact of COVID-19 in children with Sickle Cell Disease: Results of a multicentric registry
<h4>Objective</h4> To analyze the outcomes of children with sickle cell disease (SCD) and COVID-19. <h4>Method</h4> A multicenter prospective study was conducted in five hematological centers from Central and Southeast Brazil, starting in April 2020. The variables recorded in...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079108/?tool=EBI |
| _version_ | 1797850275531194368 |
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| author | Claudia de Melo Oliveira Victor Jablonski Soares Josefina Aparecida Pellegrini Braga Thaís Alcantara Bonilha Isis Magalhães Sandra Regina Loggetto Ciliana Rechenmacher Liane Esteves Daudt Mariana Bohns Michalowski |
| author_facet | Claudia de Melo Oliveira Victor Jablonski Soares Josefina Aparecida Pellegrini Braga Thaís Alcantara Bonilha Isis Magalhães Sandra Regina Loggetto Ciliana Rechenmacher Liane Esteves Daudt Mariana Bohns Michalowski |
| author_sort | Claudia de Melo Oliveira |
| collection | DOAJ |
| description | <h4>Objective</h4> To analyze the outcomes of children with sickle cell disease (SCD) and COVID-19. <h4>Method</h4> A multicenter prospective study was conducted in five hematological centers from Central and Southeast Brazil, starting in April 2020. The variables recorded include clinical symptoms, diagnostic methods, therapeutic measures, and treatment sites. The clinical repercussions of the infection on the initial treatment and the overall prognosis were also evaluated. <h4>Results</h4> Twenty-five unvaccinated children, aged 4 to 17 years, with SCD and a positive SARS-CoV-2 RT-PCR result participated in this study. Patients were classified as SCD types SS (n = 20, 80%) and SC (n = 5, 20%). Clinical characteristics and evolution were similar in both groups (p>0.05), except for the fetal hemoglobin value which was higher among the SC patients (p = 0.025). The most frequent symptoms were hyperthermia (72%) and cough (40%). Three children were admitted to the intensive care unit, all of whom were overweight/obese (p = 0.078). No deaths were observed. <h4>Conclusions</h4> Although SCD leads to specific complications, the results found in this sample suggest that COVID-19 does not seem to carry an increased mortality risk in pediatric patients with this disease. |
| first_indexed | 2024-04-09T18:57:45Z |
| format | Article |
| id | doaj.art-07ff4c5323ab46f68e3b9880dc2fffa8 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-09T18:57:45Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-07ff4c5323ab46f68e3b9880dc2fffa82023-04-09T05:32:16ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01184The impact of COVID-19 in children with Sickle Cell Disease: Results of a multicentric registryClaudia de Melo OliveiraVictor Jablonski SoaresJosefina Aparecida Pellegrini BragaThaís Alcantara BonilhaIsis MagalhãesSandra Regina LoggettoCiliana RechenmacherLiane Esteves DaudtMariana Bohns Michalowski<h4>Objective</h4> To analyze the outcomes of children with sickle cell disease (SCD) and COVID-19. <h4>Method</h4> A multicenter prospective study was conducted in five hematological centers from Central and Southeast Brazil, starting in April 2020. The variables recorded include clinical symptoms, diagnostic methods, therapeutic measures, and treatment sites. The clinical repercussions of the infection on the initial treatment and the overall prognosis were also evaluated. <h4>Results</h4> Twenty-five unvaccinated children, aged 4 to 17 years, with SCD and a positive SARS-CoV-2 RT-PCR result participated in this study. Patients were classified as SCD types SS (n = 20, 80%) and SC (n = 5, 20%). Clinical characteristics and evolution were similar in both groups (p>0.05), except for the fetal hemoglobin value which was higher among the SC patients (p = 0.025). The most frequent symptoms were hyperthermia (72%) and cough (40%). Three children were admitted to the intensive care unit, all of whom were overweight/obese (p = 0.078). No deaths were observed. <h4>Conclusions</h4> Although SCD leads to specific complications, the results found in this sample suggest that COVID-19 does not seem to carry an increased mortality risk in pediatric patients with this disease.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079108/?tool=EBI |
| spellingShingle | Claudia de Melo Oliveira Victor Jablonski Soares Josefina Aparecida Pellegrini Braga Thaís Alcantara Bonilha Isis Magalhães Sandra Regina Loggetto Ciliana Rechenmacher Liane Esteves Daudt Mariana Bohns Michalowski The impact of COVID-19 in children with Sickle Cell Disease: Results of a multicentric registry PLoS ONE |
| title | The impact of COVID-19 in children with Sickle Cell Disease: Results of a multicentric registry |
| title_full | The impact of COVID-19 in children with Sickle Cell Disease: Results of a multicentric registry |
| title_fullStr | The impact of COVID-19 in children with Sickle Cell Disease: Results of a multicentric registry |
| title_full_unstemmed | The impact of COVID-19 in children with Sickle Cell Disease: Results of a multicentric registry |
| title_short | The impact of COVID-19 in children with Sickle Cell Disease: Results of a multicentric registry |
| title_sort | impact of covid 19 in children with sickle cell disease results of a multicentric registry |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079108/?tool=EBI |
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