Imaging Dynamics Beneath Turbid Media via Parallelized Single‐Photon Detection
Abstract Noninvasive optical imaging through dynamic scattering media has numerous important biomedical applications but still remains a challenging task. While standard diffuse imaging methods measure optical absorption or fluorescent emission, it is also well‐established that the temporal correlat...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-08-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202201885 |
| _version_ | 1817998571319853056 |
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| author | Shiqi Xu Xi Yang Wenhui Liu Joakim Jönsson Ruobing Qian Pavan Chandra Konda Kevin C. Zhou Lucas Kreiß Haoqian Wang Qionghai Dai Edouard Berrocal Roarke Horstmeyer |
| author_facet | Shiqi Xu Xi Yang Wenhui Liu Joakim Jönsson Ruobing Qian Pavan Chandra Konda Kevin C. Zhou Lucas Kreiß Haoqian Wang Qionghai Dai Edouard Berrocal Roarke Horstmeyer |
| author_sort | Shiqi Xu |
| collection | DOAJ |
| description | Abstract Noninvasive optical imaging through dynamic scattering media has numerous important biomedical applications but still remains a challenging task. While standard diffuse imaging methods measure optical absorption or fluorescent emission, it is also well‐established that the temporal correlation of scattered coherent light diffuses through tissue much like optical intensity. Few works to date, however, have aimed to experimentally measure and process such temporal correlation data to demonstrate deep‐tissue video reconstruction of decorrelation dynamics. In this work, a single‐photon avalanche diode array camera is utilized to simultaneously monitor the temporal dynamics of speckle fluctuations at the single‐photon level from 12 different phantom tissue surface locations delivered via a customized fiber bundle array. Then a deep neural network is applied to convert the acquired single‐photon measurements into video of scattering dynamics beneath rapidly decorrelating tissue phantoms. The ability to reconstruct images of transient (0.1–0.4 s) dynamic events occurring up to 8 mm beneath a decorrelating tissue phantom with millimeter‐scale resolution is demonstrated, and it is highlighted how the model can flexibly extend to monitor flow speed within buried phantom vessels. |
| first_indexed | 2024-04-14T02:54:14Z |
| format | Article |
| id | doaj.art-08006629a3d0436a90325ac698ff5213 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-04-14T02:54:14Z |
| publishDate | 2022-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-08006629a3d0436a90325ac698ff52132022-12-22T02:16:08ZengWileyAdvanced Science2198-38442022-08-01924n/an/a10.1002/advs.202201885Imaging Dynamics Beneath Turbid Media via Parallelized Single‐Photon DetectionShiqi Xu0Xi Yang1Wenhui Liu2Joakim Jönsson3Ruobing Qian4Pavan Chandra Konda5Kevin C. Zhou6Lucas Kreiß7Haoqian Wang8Qionghai Dai9Edouard Berrocal10Roarke Horstmeyer11Department of Biomedical Engineering Duke University Durham NC 27708 USADepartment of Biomedical Engineering Duke University Durham NC 27708 USADepartment of Biomedical Engineering Duke University Durham NC 27708 USADivision of Combustion Physics Department of Physics Lund University Lund 22100 SwedenDepartment of Biomedical Engineering Duke University Durham NC 27708 USADepartment of Biomedical Engineering Duke University Durham NC 27708 USADepartment of Biomedical Engineering Duke University Durham NC 27708 USADepartment of Biomedical Engineering Duke University Durham NC 27708 USATsinghua Shenzhen International Graduate School Tsinghua University Shenzhen 518055 ChinaDepartment of Automation Tsinghua University Beijing 100084 ChinaDivision of Combustion Physics Department of Physics Lund University Lund 22100 SwedenDepartment of Biomedical Engineering Duke University Durham NC 27708 USAAbstract Noninvasive optical imaging through dynamic scattering media has numerous important biomedical applications but still remains a challenging task. While standard diffuse imaging methods measure optical absorption or fluorescent emission, it is also well‐established that the temporal correlation of scattered coherent light diffuses through tissue much like optical intensity. Few works to date, however, have aimed to experimentally measure and process such temporal correlation data to demonstrate deep‐tissue video reconstruction of decorrelation dynamics. In this work, a single‐photon avalanche diode array camera is utilized to simultaneously monitor the temporal dynamics of speckle fluctuations at the single‐photon level from 12 different phantom tissue surface locations delivered via a customized fiber bundle array. Then a deep neural network is applied to convert the acquired single‐photon measurements into video of scattering dynamics beneath rapidly decorrelating tissue phantoms. The ability to reconstruct images of transient (0.1–0.4 s) dynamic events occurring up to 8 mm beneath a decorrelating tissue phantom with millimeter‐scale resolution is demonstrated, and it is highlighted how the model can flexibly extend to monitor flow speed within buried phantom vessels.https://doi.org/10.1002/advs.202201885deep imagingdynamic scatteringsingle‐photon avalanche diode array |
| spellingShingle | Shiqi Xu Xi Yang Wenhui Liu Joakim Jönsson Ruobing Qian Pavan Chandra Konda Kevin C. Zhou Lucas Kreiß Haoqian Wang Qionghai Dai Edouard Berrocal Roarke Horstmeyer Imaging Dynamics Beneath Turbid Media via Parallelized Single‐Photon Detection Advanced Science deep imaging dynamic scattering single‐photon avalanche diode array |
| title | Imaging Dynamics Beneath Turbid Media via Parallelized Single‐Photon Detection |
| title_full | Imaging Dynamics Beneath Turbid Media via Parallelized Single‐Photon Detection |
| title_fullStr | Imaging Dynamics Beneath Turbid Media via Parallelized Single‐Photon Detection |
| title_full_unstemmed | Imaging Dynamics Beneath Turbid Media via Parallelized Single‐Photon Detection |
| title_short | Imaging Dynamics Beneath Turbid Media via Parallelized Single‐Photon Detection |
| title_sort | imaging dynamics beneath turbid media via parallelized single photon detection |
| topic | deep imaging dynamic scattering single‐photon avalanche diode array |
| url | https://doi.org/10.1002/advs.202201885 |
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