Reduced peptidoglycan synthesis capacity impairs growth of E. coli at high salt concentration

Reduced peptidoglycan synthesis capacity impairs growth of E. coli at high salt concentration

ABSTRACTGram-negative bacteria have a thin peptidoglycan layer between the cytoplasmic and outer membranes protecting the cell from osmotic challenges. Hydrolases of this structure are needed to cleave bonds to allow the newly synthesized peptidoglycan strands to be inserted by synthases. These enzy...

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Bibliographic Details
Main Authors: Dema Alodaini, Victor Hernandez-Rocamora, Gabriela Boelter, Xuyu Ma, Micheal B. Alao, Hannah M. Doherty, Jack A. Bryant, Patrick Moynihan, Danesh Moradigaravand, Monika Glinkowska, Waldemar Vollmer, Manuel Banzhaf
Format: Article
Language:English
Published: American Society for Microbiology 2024-04-01
Series:mBio
Subjects:
bacterial cell envelope
peptidoglycan
penicillin-binding proteins
peptidoglycan hydrolases
salt stress
Online Access:https://journals.asm.org/doi/10.1128/mbio.00325-24

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