LncRNA XR_001779380 Primes Epithelial Cells for IFN-γ-Mediated Gene Transcription and Facilitates Age-Dependent Intestinal Antimicrobial Defense
Epithelial cells along the mucosal surface provide the front line of defense against luminal pathogen infection in the gastrointestinal tract. These epithelial cells represent an integral component of a highly regulated communication network that can transmit essential signals to cells in the underl...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Society for Microbiology
2021-10-01
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| Series: | mBio |
| Online Access: | https://journals.asm.org/doi/10.1128/mBio.02127-21 |
| _version_ | 1831714444342722560 |
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| author | Ai-Yu Gong Yang Wang Min Li Xin-Tian Zhang Silu Deng Jessie M. Chen Eugene Lu Nicholas W. Mathy Gislaine A. Martins Juliane K. Strauss-Soukup Xian-Ming Chen |
| author_facet | Ai-Yu Gong Yang Wang Min Li Xin-Tian Zhang Silu Deng Jessie M. Chen Eugene Lu Nicholas W. Mathy Gislaine A. Martins Juliane K. Strauss-Soukup Xian-Ming Chen |
| author_sort | Ai-Yu Gong |
| collection | DOAJ |
| description | Epithelial cells along the mucosal surface provide the front line of defense against luminal pathogen infection in the gastrointestinal tract. These epithelial cells represent an integral component of a highly regulated communication network that can transmit essential signals to cells in the underlying intestinal mucosa that, in turn, serve as targets of mucosal immune mediators. |
| first_indexed | 2024-12-20T23:59:49Z |
| format | Article |
| id | doaj.art-0801779eeecf4115bddb57f5ae461f83 |
| institution | Directory Open Access Journal |
| issn | 2150-7511 |
| language | English |
| last_indexed | 2024-12-20T23:59:49Z |
| publishDate | 2021-10-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj.art-0801779eeecf4115bddb57f5ae461f832022-12-21T19:22:38ZengAmerican Society for MicrobiologymBio2150-75112021-10-0112510.1128/mBio.02127-21LncRNA XR_001779380 Primes Epithelial Cells for IFN-γ-Mediated Gene Transcription and Facilitates Age-Dependent Intestinal Antimicrobial DefenseAi-Yu Gong0Yang Wang1Min Li2Xin-Tian Zhang3Silu Deng4Jessie M. Chen5Eugene Lu6Nicholas W. Mathy7Gislaine A. Martins8Juliane K. Strauss-Soukup9Xian-Ming Chen10https://orcid.org/0000-0001-9848-2244Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois, USADepartment of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska, USADepartment of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska, USADepartment of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska, USADepartment of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois, USADepartment of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska, USADepartment of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska, USADepartment of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska, USADeptartments of Medicine and Biomedical Sciences, Research Division of Immunology Cedars-Sinai Medical Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USADepartment of Chemistry, Creighton University College of Arts and Sciences, Omaha, Nebraska, USADepartment of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois, USAEpithelial cells along the mucosal surface provide the front line of defense against luminal pathogen infection in the gastrointestinal tract. These epithelial cells represent an integral component of a highly regulated communication network that can transmit essential signals to cells in the underlying intestinal mucosa that, in turn, serve as targets of mucosal immune mediators.https://journals.asm.org/doi/10.1128/mBio.02127-21 |
| spellingShingle | Ai-Yu Gong Yang Wang Min Li Xin-Tian Zhang Silu Deng Jessie M. Chen Eugene Lu Nicholas W. Mathy Gislaine A. Martins Juliane K. Strauss-Soukup Xian-Ming Chen LncRNA XR_001779380 Primes Epithelial Cells for IFN-γ-Mediated Gene Transcription and Facilitates Age-Dependent Intestinal Antimicrobial Defense mBio |
| title | LncRNA XR_001779380 Primes Epithelial Cells for IFN-γ-Mediated Gene Transcription and Facilitates Age-Dependent Intestinal Antimicrobial Defense |
| title_full | LncRNA XR_001779380 Primes Epithelial Cells for IFN-γ-Mediated Gene Transcription and Facilitates Age-Dependent Intestinal Antimicrobial Defense |
| title_fullStr | LncRNA XR_001779380 Primes Epithelial Cells for IFN-γ-Mediated Gene Transcription and Facilitates Age-Dependent Intestinal Antimicrobial Defense |
| title_full_unstemmed | LncRNA XR_001779380 Primes Epithelial Cells for IFN-γ-Mediated Gene Transcription and Facilitates Age-Dependent Intestinal Antimicrobial Defense |
| title_short | LncRNA XR_001779380 Primes Epithelial Cells for IFN-γ-Mediated Gene Transcription and Facilitates Age-Dependent Intestinal Antimicrobial Defense |
| title_sort | lncrna xr 001779380 primes epithelial cells for ifn γ mediated gene transcription and facilitates age dependent intestinal antimicrobial defense |
| url | https://journals.asm.org/doi/10.1128/mBio.02127-21 |
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