Dopamine Reduces SARS-CoV-2 Replication In Vitro through Downregulation of D2 Receptors and Upregulation of Type-I Interferons

Dopamine Reduces SARS-CoV-2 Replication In Vitro through Downregulation of D2 Receptors and Upregulation of Type-I Interferons

Recent evidence suggests that SARS-CoV-2 hinders immune responses via dopamine (DA)-related mechanisms. Nonetheless, studies addressing the specific role of DA in the frame of SARS-CoV-2 infection are still missing. In the present study, we investigate the role of DA in SARS-CoV-2 replication along...

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Bibliographic Details
Main Authors: Fiona Limanaqi, Silvia Zecchini, Borana Dino, Sergio Strizzi, Gioia Cappelletti, Olga Utyro, Claudia Vanetti, Micaela Garziano, Irma Saulle, Mario Clerici, Mara Biasin
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cells
Subjects:
dopamine
D2DR
interferons
quinpirole
NLRP3 inflammasome
Online Access:https://www.mdpi.com/2073-4409/11/10/1691

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