Skin involvement in neuroendocrine neoplasia
Neuroendocrine neoplasia (NEN), priory known as neuroendocrine tumours represent the modern approach of traditionally named “carcinoid” tumours. We shortly introduce benign and malign dermatological aspects that are linked to NEN field. This is a multidisciplinary perspective. The paper is a mini-re...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Amaltea Medical Publishing House
2020-03-01
|
| Series: | Romanian Journal of Medical Practice |
| Subjects: | |
| Online Access: | https://rjmp.com.ro/articles/2020.1/RJMP_2020_1_Art-07.pdf |
| _version_ | 1818903871196495872 |
|---|---|
| author | Ana VALEA Florica SANDRU Simona Elena ALBU Mihai Cristian DUMITRASCU Dana TERZEA Ana Maria Alexandra STANESCU Mara CARSOTE |
| author_facet | Ana VALEA Florica SANDRU Simona Elena ALBU Mihai Cristian DUMITRASCU Dana TERZEA Ana Maria Alexandra STANESCU Mara CARSOTE |
| author_sort | Ana VALEA |
| collection | DOAJ |
| description | Neuroendocrine neoplasia (NEN), priory known as neuroendocrine tumours represent the modern approach of traditionally named “carcinoid” tumours. We shortly introduce benign and malign dermatological aspects that are linked to NEN field. This is a multidisciplinary perspective. The paper is a mini-review. 30 articles are included as references. NEN represents 2% of all cancers, being considered orphan disease.
Skin and soft tissue are exceptional sites of NEN, the majority are actually secondary spreading of NEN of other locations. Little data have been published related to the topic. Some cases reports showed invasion of dermis and subcutis, probably more frequent in older adults. The entity has been named low-grade neuroendocrine carcinoma of the skin, also named primary cutaneous carcinoid tumour. As seen in NEN diagnosis, the immunohistochemistry is essential like chromogranin A, synaptophysin, neuron specific enolase which are classical neuroendocrine markers and non-neuroendocrine parameters are useful for differential diagnosis like estrogens, androgens and progesterone receptors, GATA3, carcinoembryonic antigen. Merkel cell carcinoma represents the high grade NEN. It has a poor prognosis, with a 30% risk of local metastasis. The risk factors are either viral infection like Merkel cell polyomavirus, either long time exposure to ultraviolet light. The prognostic is similar between the two factors. Surgical removal is the first line therapy and adjuvant treatment is radiotherapy and chemotherapy. Skin NEN represents an exceptional finding of aggressive profile. Their prompt recognition may help the prognosis. |
| first_indexed | 2024-12-19T20:58:25Z |
| format | Article |
| id | doaj.art-08025de06997415fa7a09cb85b32aa3f |
| institution | Directory Open Access Journal |
| issn | 1842-8258 2069-6108 |
| language | English |
| last_indexed | 2024-12-19T20:58:25Z |
| publishDate | 2020-03-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Medical Practice |
| spelling | doaj.art-08025de06997415fa7a09cb85b32aa3f2022-12-21T20:05:52ZengAmaltea Medical Publishing HouseRomanian Journal of Medical Practice1842-82582069-61082020-03-01151333610.37897/RJMP.2020.1.7Skin involvement in neuroendocrine neoplasiaAna VALEA0Florica SANDRU1Simona Elena ALBU2Mihai Cristian DUMITRASCU3Dana TERZEA4Ana Maria Alexandra STANESCU5Mara CARSOTE6Clinical County Hospital, Cluj-Napoca, Romania; “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; Elias Emergency University Hospital, Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; Emergency University Hospital, Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; Emergency University Hospital, Bucharest, Romania“C.I. Parhon” National Institute of Endocrinology, Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; “C.I. Parhon” National Institute of Endocrinology, Bucharest, RomaniaNeuroendocrine neoplasia (NEN), priory known as neuroendocrine tumours represent the modern approach of traditionally named “carcinoid” tumours. We shortly introduce benign and malign dermatological aspects that are linked to NEN field. This is a multidisciplinary perspective. The paper is a mini-review. 30 articles are included as references. NEN represents 2% of all cancers, being considered orphan disease. Skin and soft tissue are exceptional sites of NEN, the majority are actually secondary spreading of NEN of other locations. Little data have been published related to the topic. Some cases reports showed invasion of dermis and subcutis, probably more frequent in older adults. The entity has been named low-grade neuroendocrine carcinoma of the skin, also named primary cutaneous carcinoid tumour. As seen in NEN diagnosis, the immunohistochemistry is essential like chromogranin A, synaptophysin, neuron specific enolase which are classical neuroendocrine markers and non-neuroendocrine parameters are useful for differential diagnosis like estrogens, androgens and progesterone receptors, GATA3, carcinoembryonic antigen. Merkel cell carcinoma represents the high grade NEN. It has a poor prognosis, with a 30% risk of local metastasis. The risk factors are either viral infection like Merkel cell polyomavirus, either long time exposure to ultraviolet light. The prognostic is similar between the two factors. Surgical removal is the first line therapy and adjuvant treatment is radiotherapy and chemotherapy. Skin NEN represents an exceptional finding of aggressive profile. Their prompt recognition may help the prognosis.https://rjmp.com.ro/articles/2020.1/RJMP_2020_1_Art-07.pdfskinneuroendocrine neoplasiamelanoma |
| spellingShingle | Ana VALEA Florica SANDRU Simona Elena ALBU Mihai Cristian DUMITRASCU Dana TERZEA Ana Maria Alexandra STANESCU Mara CARSOTE Skin involvement in neuroendocrine neoplasia Romanian Journal of Medical Practice skin neuroendocrine neoplasia melanoma |
| title | Skin involvement in neuroendocrine neoplasia |
| title_full | Skin involvement in neuroendocrine neoplasia |
| title_fullStr | Skin involvement in neuroendocrine neoplasia |
| title_full_unstemmed | Skin involvement in neuroendocrine neoplasia |
| title_short | Skin involvement in neuroendocrine neoplasia |
| title_sort | skin involvement in neuroendocrine neoplasia |
| topic | skin neuroendocrine neoplasia melanoma |
| url | https://rjmp.com.ro/articles/2020.1/RJMP_2020_1_Art-07.pdf |
| work_keys_str_mv | AT anavalea skininvolvementinneuroendocrineneoplasia AT floricasandru skininvolvementinneuroendocrineneoplasia AT simonaelenaalbu skininvolvementinneuroendocrineneoplasia AT mihaicristiandumitrascu skininvolvementinneuroendocrineneoplasia AT danaterzea skininvolvementinneuroendocrineneoplasia AT anamariaalexandrastanescu skininvolvementinneuroendocrineneoplasia AT maracarsote skininvolvementinneuroendocrineneoplasia |