The Insulin-like Growth Factor Signalling Pathway in Cardiac Development and Regeneration
Insulin and Insulin-like growth factors (IGFs) perform key roles during embryonic development, regulating processes of cell proliferation and survival. The IGF signalling pathway comprises two IGFs (IGF1, IGF2), two IGF receptors (IGFR1, IGFR2), and six IGF binding proteins (IGFBPs) that regulate IG...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/1/234 |
| _version_ | 1797498847921963008 |
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| author | Sandra Díaz del Moral Maha Benaouicha Ramón Muñoz-Chápuli Rita Carmona |
| author_facet | Sandra Díaz del Moral Maha Benaouicha Ramón Muñoz-Chápuli Rita Carmona |
| author_sort | Sandra Díaz del Moral |
| collection | DOAJ |
| description | Insulin and Insulin-like growth factors (IGFs) perform key roles during embryonic development, regulating processes of cell proliferation and survival. The IGF signalling pathway comprises two IGFs (IGF1, IGF2), two IGF receptors (IGFR1, IGFR2), and six IGF binding proteins (IGFBPs) that regulate IGF transport and availability. The IGF signalling pathway is essential for cardiac development. IGF2 is the primary mitogen inducing ventricular cardiomyocyte proliferation and morphogenesis of the compact myocardial wall. Conditional deletion of the <i>Igf1r</i> and the insulin receptor (<i>Insr</i>) genes in the myocardium results in decreased cardiomyocyte proliferation and ventricular wall hypoplasia. The significance of the IGF signalling pathway during embryonic development has led to consider it as a candidate for adult cardiac repair and regeneration. In fact, paracrine IGF2 plays a key role in the transient regenerative ability of the newborn mouse heart. We aimed to review the current knowledge about the role played by the IGF signalling pathway during cardiac development and also the clinical potential of recapitulating this developmental axis in regeneration of the adult heart. |
| first_indexed | 2024-03-10T03:39:14Z |
| format | Article |
| id | doaj.art-08042b6b7ecf445192b37c5936d92135 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T03:39:14Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-08042b6b7ecf445192b37c5936d921352023-11-23T11:36:50ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-12-0123123410.3390/ijms23010234The Insulin-like Growth Factor Signalling Pathway in Cardiac Development and RegenerationSandra Díaz del Moral0Maha Benaouicha1Ramón Muñoz-Chápuli2Rita Carmona3Institute of Biomedical Research of Málaga (IBIMA), Department of Animal Biology, Andalusian Center for Nanomedicine and Biotechnology (BIONAND), Faculty of Science, University of Málaga, 29071 Malaga, SpainInstitute of Biomedical Research of Málaga (IBIMA), Department of Animal Biology, Andalusian Center for Nanomedicine and Biotechnology (BIONAND), Faculty of Science, University of Málaga, 29071 Malaga, SpainInstitute of Biomedical Research of Málaga (IBIMA), Department of Animal Biology, Andalusian Center for Nanomedicine and Biotechnology (BIONAND), Faculty of Science, University of Málaga, 29071 Malaga, SpainInstitute of Biomedical Research of Málaga (IBIMA), Department of Animal Biology, Andalusian Center for Nanomedicine and Biotechnology (BIONAND), Faculty of Science, University of Málaga, 29071 Malaga, SpainInsulin and Insulin-like growth factors (IGFs) perform key roles during embryonic development, regulating processes of cell proliferation and survival. The IGF signalling pathway comprises two IGFs (IGF1, IGF2), two IGF receptors (IGFR1, IGFR2), and six IGF binding proteins (IGFBPs) that regulate IGF transport and availability. The IGF signalling pathway is essential for cardiac development. IGF2 is the primary mitogen inducing ventricular cardiomyocyte proliferation and morphogenesis of the compact myocardial wall. Conditional deletion of the <i>Igf1r</i> and the insulin receptor (<i>Insr</i>) genes in the myocardium results in decreased cardiomyocyte proliferation and ventricular wall hypoplasia. The significance of the IGF signalling pathway during embryonic development has led to consider it as a candidate for adult cardiac repair and regeneration. In fact, paracrine IGF2 plays a key role in the transient regenerative ability of the newborn mouse heart. We aimed to review the current knowledge about the role played by the IGF signalling pathway during cardiac development and also the clinical potential of recapitulating this developmental axis in regeneration of the adult heart.https://www.mdpi.com/1422-0067/23/1/234insulin-like growth factorsinsulin-like growth factor receptorsheart developmentmyocardial proliferation |
| spellingShingle | Sandra Díaz del Moral Maha Benaouicha Ramón Muñoz-Chápuli Rita Carmona The Insulin-like Growth Factor Signalling Pathway in Cardiac Development and Regeneration International Journal of Molecular Sciences insulin-like growth factors insulin-like growth factor receptors heart development myocardial proliferation |
| title | The Insulin-like Growth Factor Signalling Pathway in Cardiac Development and Regeneration |
| title_full | The Insulin-like Growth Factor Signalling Pathway in Cardiac Development and Regeneration |
| title_fullStr | The Insulin-like Growth Factor Signalling Pathway in Cardiac Development and Regeneration |
| title_full_unstemmed | The Insulin-like Growth Factor Signalling Pathway in Cardiac Development and Regeneration |
| title_short | The Insulin-like Growth Factor Signalling Pathway in Cardiac Development and Regeneration |
| title_sort | insulin like growth factor signalling pathway in cardiac development and regeneration |
| topic | insulin-like growth factors insulin-like growth factor receptors heart development myocardial proliferation |
| url | https://www.mdpi.com/1422-0067/23/1/234 |
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