A Breast Tissue Protein Expression Profile Contributing to Early Parity-Induced Protection Against Breast Cancer
Background/Aims: Early parity reduces breast cancer risk, whereas, late parity and nulliparity increase breast cancer risk. Despite substantial efforts to understand the protective effects of early parity, the precise molecular circuitry responsible for these changes is not yet fully defined. Method...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Cell Physiol Biochem Press GmbH & Co KG
2015-11-01
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| Series: | Cellular Physiology and Biochemistry |
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| Online Access: | http://www.karger.com/Article/FullText/438533 |
| _version_ | 1818309792143245312 |
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| author | Christina Marie Gutierrez Rebecca Lopez-Valdez Ramadevi Subramani Arunkumar Arumugam Sushmita Nandy Venkatesh Rajamanickam Vignesh Ravichandran Rajkumar Lakshmanaswamy |
| author_facet | Christina Marie Gutierrez Rebecca Lopez-Valdez Ramadevi Subramani Arunkumar Arumugam Sushmita Nandy Venkatesh Rajamanickam Vignesh Ravichandran Rajkumar Lakshmanaswamy |
| author_sort | Christina Marie Gutierrez |
| collection | DOAJ |
| description | Background/Aims: Early parity reduces breast cancer risk, whereas, late parity and nulliparity increase breast cancer risk. Despite substantial efforts to understand the protective effects of early parity, the precise molecular circuitry responsible for these changes is not yet fully defined. Methods: Here, we have conducted the first study assessing protein expression profiles in normal breast tissue of healthy early parous, late parous, and nulliparous women. Breast tissue biopsies were obtained from 132 healthy parous and nulliparous volunteers. These samples were subjected to global protein expression profiling and immunohistochemistry. GeneSpring and MetaCore bioinformatics analysis software were used to identify protein expression profiles associated with early parity (low risk) versus late/nulliparity (high risk). Results: Early parity reduces expression of key proteins involved in mitogenic signaling pathways in breast tissue through down regulation of EGFR1/3, ESR1, AKT1, ATF, Fos, and SRC. Early parity is also characterized by greater genomic stability and reduced tissue inflammation based on differential expression of aurora kinases, p53, RAD52, BRCA1, MAPKAPK-2, ATF-1, ICAM1, and NF-kappaB compared to late and nulli parity. Conclusions: Early parity reduces basal cell proliferation in breast tissue, which translates to enhanced genomic stability, reduced cellular stress/inflammation, and thus reduced breast cancer risk. |
| first_indexed | 2024-12-13T07:35:48Z |
| format | Article |
| id | doaj.art-0805d950c6664837acfc608a3eda85a5 |
| institution | Directory Open Access Journal |
| issn | 1015-8987 1421-9778 |
| language | English |
| last_indexed | 2024-12-13T07:35:48Z |
| publishDate | 2015-11-01 |
| publisher | Cell Physiol Biochem Press GmbH & Co KG |
| record_format | Article |
| series | Cellular Physiology and Biochemistry |
| spelling | doaj.art-0805d950c6664837acfc608a3eda85a52022-12-21T23:55:05ZengCell Physiol Biochem Press GmbH & Co KGCellular Physiology and Biochemistry1015-89871421-97782015-11-013751671168510.1159/000438533438533A Breast Tissue Protein Expression Profile Contributing to Early Parity-Induced Protection Against Breast CancerChristina Marie GutierrezRebecca Lopez-ValdezRamadevi SubramaniArunkumar ArumugamSushmita NandyVenkatesh RajamanickamVignesh RavichandranRajkumar LakshmanaswamyBackground/Aims: Early parity reduces breast cancer risk, whereas, late parity and nulliparity increase breast cancer risk. Despite substantial efforts to understand the protective effects of early parity, the precise molecular circuitry responsible for these changes is not yet fully defined. Methods: Here, we have conducted the first study assessing protein expression profiles in normal breast tissue of healthy early parous, late parous, and nulliparous women. Breast tissue biopsies were obtained from 132 healthy parous and nulliparous volunteers. These samples were subjected to global protein expression profiling and immunohistochemistry. GeneSpring and MetaCore bioinformatics analysis software were used to identify protein expression profiles associated with early parity (low risk) versus late/nulliparity (high risk). Results: Early parity reduces expression of key proteins involved in mitogenic signaling pathways in breast tissue through down regulation of EGFR1/3, ESR1, AKT1, ATF, Fos, and SRC. Early parity is also characterized by greater genomic stability and reduced tissue inflammation based on differential expression of aurora kinases, p53, RAD52, BRCA1, MAPKAPK-2, ATF-1, ICAM1, and NF-kappaB compared to late and nulli parity. Conclusions: Early parity reduces basal cell proliferation in breast tissue, which translates to enhanced genomic stability, reduced cellular stress/inflammation, and thus reduced breast cancer risk.http://www.karger.com/Article/FullText/438533Breast cancerParityPreventionProteinBiomarkers |
| spellingShingle | Christina Marie Gutierrez Rebecca Lopez-Valdez Ramadevi Subramani Arunkumar Arumugam Sushmita Nandy Venkatesh Rajamanickam Vignesh Ravichandran Rajkumar Lakshmanaswamy A Breast Tissue Protein Expression Profile Contributing to Early Parity-Induced Protection Against Breast Cancer Cellular Physiology and Biochemistry Breast cancer Parity Prevention Protein Biomarkers |
| title | A Breast Tissue Protein Expression Profile Contributing to Early Parity-Induced Protection Against Breast Cancer |
| title_full | A Breast Tissue Protein Expression Profile Contributing to Early Parity-Induced Protection Against Breast Cancer |
| title_fullStr | A Breast Tissue Protein Expression Profile Contributing to Early Parity-Induced Protection Against Breast Cancer |
| title_full_unstemmed | A Breast Tissue Protein Expression Profile Contributing to Early Parity-Induced Protection Against Breast Cancer |
| title_short | A Breast Tissue Protein Expression Profile Contributing to Early Parity-Induced Protection Against Breast Cancer |
| title_sort | breast tissue protein expression profile contributing to early parity induced protection against breast cancer |
| topic | Breast cancer Parity Prevention Protein Biomarkers |
| url | http://www.karger.com/Article/FullText/438533 |
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