Establishment and Validation of a Rabbit Model for In Vivo Pharmacodynamic Screening of Tachykinin NK2 Antagonists

Establishment and Validation of a Rabbit Model for In Vivo Pharmacodynamic Screening of Tachykinin NK2 Antagonists

We attempted to establish and validate an in vivo pharmacodynamic (PD) rabbit model to screen tachykinin NK2 receptor (NK2-R) antagonists using pharmacological and pharmacokinetic (PK)/PD analyses. Under urethane anesthesia, changes in intracolonic pressure associated with intravenous (i.v.) adminis...

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Main Authors: Takahiro Tanaka, Shiho Matsumoto-Okano, Nobuhiro Inatomi, Yasushi Fujioka, Hidenori Kamiguchi, Masashi Yamaguchi, Akio Imanishi, Makiko Kawamoto, Kasei Miura, Yoichi Nishikawa, Yasuhiro Tsukimi
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319305420

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