Epac2 activation mediates glucagon‐induced glucogenesis in primary rat hepatocytes

Epac2 activation mediates glucagon‐induced glucogenesis in primary rat hepatocytes

ABSTRACT Aims/Introduction Glucagon plays an essential role in hepatic glucogenesis by enhancing glycogen breakdown, inducing gluconeogenesis, and suppressing glycogenesis. Moreover, glucagon increases cyclic adenosine monophosphate (cAMP) levels, thereby activating protein kinase A (PKA) and cAMP g...

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Bibliographic Details
Main Authors: Yusuke Shiozaki‐Takagi, Nobuaki Ozaki, Yukiyasu Toyoda
Format: Article
Language:English
Published: Wiley 2024-04-01
Series:Journal of Diabetes Investigation
Subjects:
EPAC
Glucagon
Glucogenic action
Online Access:https://doi.org/10.1111/jdi.14142

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