Inactivation and inducible oncogenic mutation of p53 in gene targeted pigs.

Inactivation and inducible oncogenic mutation of p53 in gene targeted pigs.

Mutation of the tumor suppressor p53 plays a major role in human carcinogenesis. Here we describe gene-targeted porcine mesenchymal stem cells (MSCs) and live pigs carrying a latent TP53(R167H) mutant allele, orthologous to oncogenic human mutant TP53(R175H) and mouse Trp53(R172H), that can be activ...

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Main Authors: Simon Leuchs, Anja Saalfrank, Claudia Merkl, Tatiana Flisikowska, Marlene Edlinger, Marina Durkovic, Nousin Rezaei, Mayuko Kurome, Valeri Zakhartchenko, Barbara Kessler, Krzysztof Flisikowski, Alexander Kind, Eckhard Wolf, Angelika Schnieke
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23071491/?tool=EBI

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