Antioxidants Promote Intestinal Tumor Progression in Mice
Dietary antioxidants and supplements are widely used to protect against cancer, even though it is now clear that antioxidants can promote tumor progression by helping cancer cells to overcome barriers of oxidative stress. Although recent studies have, in great detail, explored the role of antioxidan...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/2/241 |
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| author | Zhiyuan V. Zou Kristell Le Gal Ahmed E. El Zowalaty Lara E. Pehlivanoglu Viktor Garellick Nadia Gul Mohamed X. Ibrahim Per-Olof Bergh Marcus Henricsson Clotilde Wiel Levent M. Akyürek Martin O. Bergo Volkan I. Sayin Per Lindahl |
| author_facet | Zhiyuan V. Zou Kristell Le Gal Ahmed E. El Zowalaty Lara E. Pehlivanoglu Viktor Garellick Nadia Gul Mohamed X. Ibrahim Per-Olof Bergh Marcus Henricsson Clotilde Wiel Levent M. Akyürek Martin O. Bergo Volkan I. Sayin Per Lindahl |
| author_sort | Zhiyuan V. Zou |
| collection | DOAJ |
| description | Dietary antioxidants and supplements are widely used to protect against cancer, even though it is now clear that antioxidants can promote tumor progression by helping cancer cells to overcome barriers of oxidative stress. Although recent studies have, in great detail, explored the role of antioxidants in lung and skin tumors driven by RAS and RAF mutations, little is known about the impact of antioxidant supplementation on other cancers, including Wnt-driven tumors originating from the gut. Here, we show that supplementation with the antioxidants N-acetylcysteine (NAC) and vitamin E promotes intestinal tumor progression in the ApcMin mouse model for familial adenomatous polyposis, a hereditary form of colorectal cancer, driven by Wnt signaling. Both antioxidants increased tumor size in early neoplasias and tumor grades in more advanced lesions without any impact on tumor initiation. Importantly, NAC treatment accelerated tumor progression at plasma concentrations comparable to those obtained in human subjects after prescription doses of the drug. These results demonstrate that antioxidants play an important role in the progression of intestinal tumors, which may have implications for patients with or predisposed to colorectal cancer. |
| first_indexed | 2024-03-09T05:39:43Z |
| format | Article |
| id | doaj.art-080aefb9e0cd473fb29d3da2d5029ec5 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T05:39:43Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-080aefb9e0cd473fb29d3da2d5029ec52023-12-03T12:25:21ZengMDPI AGAntioxidants2076-39212021-02-0110224110.3390/antiox10020241Antioxidants Promote Intestinal Tumor Progression in MiceZhiyuan V. Zou0Kristell Le Gal1Ahmed E. El Zowalaty2Lara E. Pehlivanoglu3Viktor Garellick4Nadia Gul5Mohamed X. Ibrahim6Per-Olof Bergh7Marcus Henricsson8Clotilde Wiel9Levent M. Akyürek10Martin O. Bergo11Volkan I. Sayin12Per Lindahl13Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, 405 30 Gothenburg, SwedenSahlgrenska Center for Cancer Research, Department of Surgery, Institute of Clinical Sciences, University of Gothenburg, 405 30 Gothenburg, SwedenSahlgrenska Center for Cancer Research, Department of Surgery, Institute of Clinical Sciences, University of Gothenburg, 405 30 Gothenburg, SwedenWallenberg Laboratory, Institute of Medicine, University of Gothenburg, 405 30 Gothenburg, SwedenWallenberg Laboratory, Institute of Medicine, University of Gothenburg, 405 30 Gothenburg, SwedenWallenberg Laboratory, Institute of Medicine, University of Gothenburg, 405 30 Gothenburg, SwedenSahlgrenska Center for Cancer Research, Department of Surgery, Institute of Clinical Sciences, University of Gothenburg, 405 30 Gothenburg, SwedenWallenberg Laboratory, Institute of Medicine, University of Gothenburg, 405 30 Gothenburg, SwedenWallenberg Laboratory, Institute of Medicine, University of Gothenburg, 405 30 Gothenburg, SwedenSahlgrenska Center for Cancer Research, Department of Surgery, Institute of Clinical Sciences, University of Gothenburg, 405 30 Gothenburg, SwedenDepartment of Pathology, Institute of Biomedicine, University of Gothenburg, 405 30 Gothenburg, SwedenDepartment of Biosciences and Nutrition, Karolinska Institute, 141 83 Huddinge, SwedenSahlgrenska Center for Cancer Research, Department of Surgery, Institute of Clinical Sciences, University of Gothenburg, 405 30 Gothenburg, SwedenWallenberg Laboratory, Institute of Medicine, University of Gothenburg, 405 30 Gothenburg, SwedenDietary antioxidants and supplements are widely used to protect against cancer, even though it is now clear that antioxidants can promote tumor progression by helping cancer cells to overcome barriers of oxidative stress. Although recent studies have, in great detail, explored the role of antioxidants in lung and skin tumors driven by RAS and RAF mutations, little is known about the impact of antioxidant supplementation on other cancers, including Wnt-driven tumors originating from the gut. Here, we show that supplementation with the antioxidants N-acetylcysteine (NAC) and vitamin E promotes intestinal tumor progression in the ApcMin mouse model for familial adenomatous polyposis, a hereditary form of colorectal cancer, driven by Wnt signaling. Both antioxidants increased tumor size in early neoplasias and tumor grades in more advanced lesions without any impact on tumor initiation. Importantly, NAC treatment accelerated tumor progression at plasma concentrations comparable to those obtained in human subjects after prescription doses of the drug. These results demonstrate that antioxidants play an important role in the progression of intestinal tumors, which may have implications for patients with or predisposed to colorectal cancer.https://www.mdpi.com/2076-3921/10/2/241dietary antioxidantsintestinal tumorstumor progressioninflammation |
| spellingShingle | Zhiyuan V. Zou Kristell Le Gal Ahmed E. El Zowalaty Lara E. Pehlivanoglu Viktor Garellick Nadia Gul Mohamed X. Ibrahim Per-Olof Bergh Marcus Henricsson Clotilde Wiel Levent M. Akyürek Martin O. Bergo Volkan I. Sayin Per Lindahl Antioxidants Promote Intestinal Tumor Progression in Mice Antioxidants dietary antioxidants intestinal tumors tumor progression inflammation |
| title | Antioxidants Promote Intestinal Tumor Progression in Mice |
| title_full | Antioxidants Promote Intestinal Tumor Progression in Mice |
| title_fullStr | Antioxidants Promote Intestinal Tumor Progression in Mice |
| title_full_unstemmed | Antioxidants Promote Intestinal Tumor Progression in Mice |
| title_short | Antioxidants Promote Intestinal Tumor Progression in Mice |
| title_sort | antioxidants promote intestinal tumor progression in mice |
| topic | dietary antioxidants intestinal tumors tumor progression inflammation |
| url | https://www.mdpi.com/2076-3921/10/2/241 |
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