The impact on clinical outcome of high prevalence of diabetes mellitus in Taiwanese patients with colorectal cancer
<p>Abstract</p> <p>Background</p> <p>Both colorectal cancer (CRC) and diabetes mellitus (DM) are important public health problems worldwide. As there are controversies about survival impact on CRC patients with preexisting DM, the purpose of the present study is to eval...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-05-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | http://www.wjso.com/content/10/1/76 |
| _version_ | 1819139448213864448 |
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| author | Huang Ching-Wen Sun Li-Chu Shih Ying-Ling Tsai Hsiang-Lin Chen Chao-Wen Yeh Yung-Sung Ma Cheng-Jen Huang Che-Jen Wang Jaw-Yuan |
| author_facet | Huang Ching-Wen Sun Li-Chu Shih Ying-Ling Tsai Hsiang-Lin Chen Chao-Wen Yeh Yung-Sung Ma Cheng-Jen Huang Che-Jen Wang Jaw-Yuan |
| author_sort | Huang Ching-Wen |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Both colorectal cancer (CRC) and diabetes mellitus (DM) are important public health problems worldwide. As there are controversies about survival impact on CRC patients with preexisting DM, the purpose of the present study is to evaluate the incidence and the survival impact of preexisting DM on the long-term outcomes of patients with CRC in Taiwan.</p> <p>Methods</p> <p>From January 2002 to December 2008, 1,197 consecutive patients with histologically proven primary CRC, who received surgical treatment at a single institution, were enrolled. The clinicopathologic features between these patients with and without DM were retrospectively investigated. Moreover, we intended to analyze the impact of DM on overall survival (OS) and cancer-specific survival (CSS) rates.</p> <p>Results</p> <p>Of 1,197 CRC patients, 23.6% of patients had either a reported history of DM or were currently taking one or more diabetes-controlling medications. CRC patients with DM were significantly older than those without DM (<it>P</it> < 0.001), and had a higher incidence of cardiac disease and higher body mass index than those without DM (both <it>P</it> < 0.001). There were no significant differences in gender, tumor size, tumor location, histological type, AJCC/UICC cancer stage, vascular invasion, perineural invasion, comorbidity of pulmonary disease or renal disease, and OS, and CSS between two groups. Additionally, DM patients had a higher incidence of second malignancy than patients without DM (9.54% <it>vs</it> 6.01%, <it>P</it> = 0.040).</p> <p>Conclusions</p> <p>A considerably high prevalence of DM in CRC patients but no significant impact of DM on survival was observed in the single-institution retrospective study, regardless of cancer stages and tumor locations. Therefore, treatment strategies for CRC patients with DM should be the same as patients without DM.</p> |
| first_indexed | 2024-12-22T11:22:49Z |
| format | Article |
| id | doaj.art-080b020730334cbb8c2b9df62258629c |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-22T11:22:49Z |
| publishDate | 2012-05-01 |
| publisher | BMC |
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| series | World Journal of Surgical Oncology |
| spelling | doaj.art-080b020730334cbb8c2b9df62258629c2022-12-21T18:27:49ZengBMCWorld Journal of Surgical Oncology1477-78192012-05-011017610.1186/1477-7819-10-76The impact on clinical outcome of high prevalence of diabetes mellitus in Taiwanese patients with colorectal cancerHuang Ching-WenSun Li-ChuShih Ying-LingTsai Hsiang-LinChen Chao-WenYeh Yung-SungMa Cheng-JenHuang Che-JenWang Jaw-Yuan<p>Abstract</p> <p>Background</p> <p>Both colorectal cancer (CRC) and diabetes mellitus (DM) are important public health problems worldwide. As there are controversies about survival impact on CRC patients with preexisting DM, the purpose of the present study is to evaluate the incidence and the survival impact of preexisting DM on the long-term outcomes of patients with CRC in Taiwan.</p> <p>Methods</p> <p>From January 2002 to December 2008, 1,197 consecutive patients with histologically proven primary CRC, who received surgical treatment at a single institution, were enrolled. The clinicopathologic features between these patients with and without DM were retrospectively investigated. Moreover, we intended to analyze the impact of DM on overall survival (OS) and cancer-specific survival (CSS) rates.</p> <p>Results</p> <p>Of 1,197 CRC patients, 23.6% of patients had either a reported history of DM or were currently taking one or more diabetes-controlling medications. CRC patients with DM were significantly older than those without DM (<it>P</it> < 0.001), and had a higher incidence of cardiac disease and higher body mass index than those without DM (both <it>P</it> < 0.001). There were no significant differences in gender, tumor size, tumor location, histological type, AJCC/UICC cancer stage, vascular invasion, perineural invasion, comorbidity of pulmonary disease or renal disease, and OS, and CSS between two groups. Additionally, DM patients had a higher incidence of second malignancy than patients without DM (9.54% <it>vs</it> 6.01%, <it>P</it> = 0.040).</p> <p>Conclusions</p> <p>A considerably high prevalence of DM in CRC patients but no significant impact of DM on survival was observed in the single-institution retrospective study, regardless of cancer stages and tumor locations. Therefore, treatment strategies for CRC patients with DM should be the same as patients without DM.</p>http://www.wjso.com/content/10/1/76High prevalenceDiabetes mellitusColorectal cancerSurvival impact |
| spellingShingle | Huang Ching-Wen Sun Li-Chu Shih Ying-Ling Tsai Hsiang-Lin Chen Chao-Wen Yeh Yung-Sung Ma Cheng-Jen Huang Che-Jen Wang Jaw-Yuan The impact on clinical outcome of high prevalence of diabetes mellitus in Taiwanese patients with colorectal cancer World Journal of Surgical Oncology High prevalence Diabetes mellitus Colorectal cancer Survival impact |
| title | The impact on clinical outcome of high prevalence of diabetes mellitus in Taiwanese patients with colorectal cancer |
| title_full | The impact on clinical outcome of high prevalence of diabetes mellitus in Taiwanese patients with colorectal cancer |
| title_fullStr | The impact on clinical outcome of high prevalence of diabetes mellitus in Taiwanese patients with colorectal cancer |
| title_full_unstemmed | The impact on clinical outcome of high prevalence of diabetes mellitus in Taiwanese patients with colorectal cancer |
| title_short | The impact on clinical outcome of high prevalence of diabetes mellitus in Taiwanese patients with colorectal cancer |
| title_sort | impact on clinical outcome of high prevalence of diabetes mellitus in taiwanese patients with colorectal cancer |
| topic | High prevalence Diabetes mellitus Colorectal cancer Survival impact |
| url | http://www.wjso.com/content/10/1/76 |
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