Novel Radioligands for Cyclic Nucleotide Phosphodiesterase Imaging with Positron Emission Tomography: An Update on Developments Since 2012

Novel Radioligands for Cyclic Nucleotide Phosphodiesterase Imaging with Positron Emission Tomography: An Update on Developments Since 2012

Cyclic nucleotide phosphodiesterases (PDEs) are a class of intracellular enzymes that inactivate the secondary messenger molecules, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Thus, PDEs regulate the signaling cascades mediated by these cyclic nucleotides and aff...

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Bibliographic Details
Main Authors: Susann Schröder, Barbara Wenzel, Winnie Deuther-Conrad, Matthias Scheunemann, Peter Brust
Format: Article
Language:English
Published: MDPI AG 2016-05-01
Series:Molecules
Subjects:
positron emission tomography
phosphodiesterases
cyclic nucleotide signaling
PDE inhibitors
PDE radioligands
imaging
Online Access:http://www.mdpi.com/1420-3049/21/5/650

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