Understanding Neutrophil Dynamics during COVID-19 Infection
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) results in varied clinical outcomes, with virus-induced chronic inflammation and tissue injury being associated with enhanced disease pathogenesis. To determine the role of tissue damage on immune populations recruitment and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Applied Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3417/13/4/2409 |
| _version_ | 1797622531083993088 |
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| author | Quiyana M. Murphy Stanca M. Ciupe |
| author_facet | Quiyana M. Murphy Stanca M. Ciupe |
| author_sort | Quiyana M. Murphy |
| collection | DOAJ |
| description | Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) results in varied clinical outcomes, with virus-induced chronic inflammation and tissue injury being associated with enhanced disease pathogenesis. To determine the role of tissue damage on immune populations recruitment and function, a mathematical model of innate immunity following SARS-CoV-2 infection has been proposed. The model was fitted to published longitudinal immune marker data from patients with mild and severe COVID-19 disease and key parameters were estimated for each clinical outcome. Analytical, bifurcation, and numerical investigations were conducted to determine the effect of parameters and initial conditions on long-term dynamics. The results were used to suggest changes needed to achieve immune resolution. |
| first_indexed | 2024-03-11T09:11:38Z |
| format | Article |
| id | doaj.art-080d571726254c26913d0ab4e1698944 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-11T09:11:38Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-080d571726254c26913d0ab4e16989442023-11-16T18:55:17ZengMDPI AGApplied Sciences2076-34172023-02-01134240910.3390/app13042409Understanding Neutrophil Dynamics during COVID-19 InfectionQuiyana M. Murphy0Stanca M. Ciupe1Department of Mathematics, Virginia Polytechnic Institute and State University, 225 Stanger Street, Blacksburg, VA 24060, USADepartment of Mathematics, Virginia Polytechnic Institute and State University, 225 Stanger Street, Blacksburg, VA 24060, USAInfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) results in varied clinical outcomes, with virus-induced chronic inflammation and tissue injury being associated with enhanced disease pathogenesis. To determine the role of tissue damage on immune populations recruitment and function, a mathematical model of innate immunity following SARS-CoV-2 infection has been proposed. The model was fitted to published longitudinal immune marker data from patients with mild and severe COVID-19 disease and key parameters were estimated for each clinical outcome. Analytical, bifurcation, and numerical investigations were conducted to determine the effect of parameters and initial conditions on long-term dynamics. The results were used to suggest changes needed to achieve immune resolution.https://www.mdpi.com/2076-3417/13/4/2409mathematical modellingneutrophilsCOVID-19SARS-CoV-2inflammationresolution |
| spellingShingle | Quiyana M. Murphy Stanca M. Ciupe Understanding Neutrophil Dynamics during COVID-19 Infection Applied Sciences mathematical modelling neutrophils COVID-19 SARS-CoV-2 inflammation resolution |
| title | Understanding Neutrophil Dynamics during COVID-19 Infection |
| title_full | Understanding Neutrophil Dynamics during COVID-19 Infection |
| title_fullStr | Understanding Neutrophil Dynamics during COVID-19 Infection |
| title_full_unstemmed | Understanding Neutrophil Dynamics during COVID-19 Infection |
| title_short | Understanding Neutrophil Dynamics during COVID-19 Infection |
| title_sort | understanding neutrophil dynamics during covid 19 infection |
| topic | mathematical modelling neutrophils COVID-19 SARS-CoV-2 inflammation resolution |
| url | https://www.mdpi.com/2076-3417/13/4/2409 |
| work_keys_str_mv | AT quiyanammurphy understandingneutrophildynamicsduringcovid19infection AT stancamciupe understandingneutrophildynamicsduringcovid19infection |