Red cell alloimmunization among antenatal women attending tertiary care center in Jamnagar, Gujarat, India
Background: The following study was conducted to measure the presence of alloantibodies of Rh and other blood group antigens produced due to fetomaternal hemorrhage in all antenatal women as well as those leading to hemolytic disease of fetus and newborn; presenting to a tertiary care center, G.G. G...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Asian Journal of Transfusion Science |
| Subjects: | |
| Online Access: | http://www.ajts.org/article.asp?issn=0973-6247;year=2021;volume=15;issue=1;spage=52;epage=56;aulast=Dholakiya |
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| author | Spruha Kashyap Dholakiya Sumit Bharadva Jitendra H Vachhani B Shweta Upadhyay |
| author_facet | Spruha Kashyap Dholakiya Sumit Bharadva Jitendra H Vachhani B Shweta Upadhyay |
| author_sort | Spruha Kashyap Dholakiya |
| collection | DOAJ |
| description | Background: The following study was conducted to measure the presence of alloantibodies of Rh and other blood group antigens produced due to fetomaternal hemorrhage in all antenatal women as well as those leading to hemolytic disease of fetus and newborn; presenting to a tertiary care center, G.G. Government Hospital, Jamnagar, Gujarat, India, between April 2014 and March 2016 (2 years).
Materials and Methods: All multiparous women irrespective of their period of gestation or obstetrics history were included whereas those having taken anti-D immunoprophylaxis or with a history of blood transfusion were excluded. Antibody screening and identification were done using Bio-Rad ID microtyping system.
Results: Out of total 8920 multigravida females, 8488 were D-antigen positive whereas 432 were D-antigen negative. A total of 126 antibodies among 117 females (1.31%) were found; out of them, 33 were found in D-antigen positive females (0.39%) and 84 in D-antigen negative ones (19.44%) looking at overall frequency of other antibodies such as anti-C: 9, anti-c: 9, anti-E: 13, anti-Cw: 1, anti-M: 5, anti-S: 8, anti-Fya: 3, and anti-D: 78; it was found that anti-D is the most common.
Conclusion: The rate of alloimmunization in D-antigen negative women was found to be very high as compared to other studies in western region; hence, strict follow-up of immunoprophylaxis of all Rh D-negative women needs to be taken care of. Apart from this, D-antigen-positive women also show alloimmunization against various antigens giving the prevalence of 0.39%; hence, it should be mandatory that there should be one standard universal protocol for screening of all antenatal women. |
| first_indexed | 2024-12-17T08:53:26Z |
| format | Article |
| id | doaj.art-080e27e753c646a59cc0914fe8d4284e |
| institution | Directory Open Access Journal |
| issn | 0973-6247 1998-3565 |
| language | English |
| last_indexed | 2024-12-17T08:53:26Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Transfusion Science |
| spelling | doaj.art-080e27e753c646a59cc0914fe8d4284e2022-12-21T21:56:01ZengWolters Kluwer Medknow PublicationsAsian Journal of Transfusion Science0973-62471998-35652021-01-01151525610.4103/ajts.AJTS_72_17Red cell alloimmunization among antenatal women attending tertiary care center in Jamnagar, Gujarat, IndiaSpruha Kashyap DholakiyaSumit BharadvaJitendra H VachhaniB Shweta UpadhyayBackground: The following study was conducted to measure the presence of alloantibodies of Rh and other blood group antigens produced due to fetomaternal hemorrhage in all antenatal women as well as those leading to hemolytic disease of fetus and newborn; presenting to a tertiary care center, G.G. Government Hospital, Jamnagar, Gujarat, India, between April 2014 and March 2016 (2 years). Materials and Methods: All multiparous women irrespective of their period of gestation or obstetrics history were included whereas those having taken anti-D immunoprophylaxis or with a history of blood transfusion were excluded. Antibody screening and identification were done using Bio-Rad ID microtyping system. Results: Out of total 8920 multigravida females, 8488 were D-antigen positive whereas 432 were D-antigen negative. A total of 126 antibodies among 117 females (1.31%) were found; out of them, 33 were found in D-antigen positive females (0.39%) and 84 in D-antigen negative ones (19.44%) looking at overall frequency of other antibodies such as anti-C: 9, anti-c: 9, anti-E: 13, anti-Cw: 1, anti-M: 5, anti-S: 8, anti-Fya: 3, and anti-D: 78; it was found that anti-D is the most common. Conclusion: The rate of alloimmunization in D-antigen negative women was found to be very high as compared to other studies in western region; hence, strict follow-up of immunoprophylaxis of all Rh D-negative women needs to be taken care of. Apart from this, D-antigen-positive women also show alloimmunization against various antigens giving the prevalence of 0.39%; hence, it should be mandatory that there should be one standard universal protocol for screening of all antenatal women.http://www.ajts.org/article.asp?issn=0973-6247;year=2021;volume=15;issue=1;spage=52;epage=56;aulast=Dholakiyaalloimmunization by fetal red cells due to fetomaternal hemorrhageblood groupshemolytic disease of fetus and newborn |
| spellingShingle | Spruha Kashyap Dholakiya Sumit Bharadva Jitendra H Vachhani B Shweta Upadhyay Red cell alloimmunization among antenatal women attending tertiary care center in Jamnagar, Gujarat, India Asian Journal of Transfusion Science alloimmunization by fetal red cells due to fetomaternal hemorrhage blood groups hemolytic disease of fetus and newborn |
| title | Red cell alloimmunization among antenatal women attending tertiary care center in Jamnagar, Gujarat, India |
| title_full | Red cell alloimmunization among antenatal women attending tertiary care center in Jamnagar, Gujarat, India |
| title_fullStr | Red cell alloimmunization among antenatal women attending tertiary care center in Jamnagar, Gujarat, India |
| title_full_unstemmed | Red cell alloimmunization among antenatal women attending tertiary care center in Jamnagar, Gujarat, India |
| title_short | Red cell alloimmunization among antenatal women attending tertiary care center in Jamnagar, Gujarat, India |
| title_sort | red cell alloimmunization among antenatal women attending tertiary care center in jamnagar gujarat india |
| topic | alloimmunization by fetal red cells due to fetomaternal hemorrhage blood groups hemolytic disease of fetus and newborn |
| url | http://www.ajts.org/article.asp?issn=0973-6247;year=2021;volume=15;issue=1;spage=52;epage=56;aulast=Dholakiya |
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