Diagnosing and Managing Uveitis Associated with Immune Checkpoint Inhibitors: A Review
This review aims to provide an understanding of the diagnostic and therapeutic challenges of uveitis associated with immune checkpoint inhibitors (ICI). In the wake of these molecules being increasingly employed as a treatment against different cancers, cases of uveitis post-ICI therapy have also be...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/14/3/336 |
| _version_ | 1797318841448005632 |
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| author | Huixin Zhang Lysa Houadj Kevin Y. Wu Simon D. Tran |
| author_facet | Huixin Zhang Lysa Houadj Kevin Y. Wu Simon D. Tran |
| author_sort | Huixin Zhang |
| collection | DOAJ |
| description | This review aims to provide an understanding of the diagnostic and therapeutic challenges of uveitis associated with immune checkpoint inhibitors (ICI). In the wake of these molecules being increasingly employed as a treatment against different cancers, cases of uveitis post-ICI therapy have also been increasingly reported in the literature, warranting an extensive exploration of the clinical presentations, risk factors, and pathophysiological mechanisms of ICI-induced uveitis. This review further provides an understanding of the association between ICIs and uveitis, and assesses the efficacy of current diagnostic tools, underscoring the need for advanced techniques to enable early detection and accurate assessment. Further, it investigates the therapeutic strategies for ICI-related uveitis, weighing the benefits and limitations of existing treatment regimens, and discussing current challenges and emerging therapies in the context of their potential efficacy and side effects. Through an overview of the short-term and long-term outcomes, this article suggests recommendations and emphasizes the importance of multidisciplinary collaboration between ophthalmologists and oncologists. Finally, the review highlights promising avenues for future research and development in the field, potentially informing transformative approaches in the ocular assessment of patients under immunotherapy and the management of uveitis following ICI therapy. |
| first_indexed | 2024-03-08T03:58:16Z |
| format | Article |
| id | doaj.art-0810880d3a444f77b9aa3e63b3360f0e |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-08T03:58:16Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-0810880d3a444f77b9aa3e63b3360f0e2024-02-09T15:10:16ZengMDPI AGDiagnostics2075-44182024-02-0114333610.3390/diagnostics14030336Diagnosing and Managing Uveitis Associated with Immune Checkpoint Inhibitors: A ReviewHuixin Zhang0Lysa Houadj1Kevin Y. Wu2Simon D. Tran3Faculty of Medicine, Laval University, Quebec, QC G1V 0A6, CanadaFaculty of Medicine, University of Sherbrooke, Sherbrooke, QC J1G 2E8, CanadaDepartment of Surgery, Division of Ophthalmology, University of Sherbrooke, Sherbrooke, QC J1G 2E8, CanadaFaculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC H3A 1G1, CanadaThis review aims to provide an understanding of the diagnostic and therapeutic challenges of uveitis associated with immune checkpoint inhibitors (ICI). In the wake of these molecules being increasingly employed as a treatment against different cancers, cases of uveitis post-ICI therapy have also been increasingly reported in the literature, warranting an extensive exploration of the clinical presentations, risk factors, and pathophysiological mechanisms of ICI-induced uveitis. This review further provides an understanding of the association between ICIs and uveitis, and assesses the efficacy of current diagnostic tools, underscoring the need for advanced techniques to enable early detection and accurate assessment. Further, it investigates the therapeutic strategies for ICI-related uveitis, weighing the benefits and limitations of existing treatment regimens, and discussing current challenges and emerging therapies in the context of their potential efficacy and side effects. Through an overview of the short-term and long-term outcomes, this article suggests recommendations and emphasizes the importance of multidisciplinary collaboration between ophthalmologists and oncologists. Finally, the review highlights promising avenues for future research and development in the field, potentially informing transformative approaches in the ocular assessment of patients under immunotherapy and the management of uveitis following ICI therapy.https://www.mdpi.com/2075-4418/14/3/336immune checkpoint inhibitoruveitisVogt-Koyanagi-Haradabirdshot-like uveitisimmunotherapyCTLA-4 inhibitors |
| spellingShingle | Huixin Zhang Lysa Houadj Kevin Y. Wu Simon D. Tran Diagnosing and Managing Uveitis Associated with Immune Checkpoint Inhibitors: A Review Diagnostics immune checkpoint inhibitor uveitis Vogt-Koyanagi-Harada birdshot-like uveitis immunotherapy CTLA-4 inhibitors |
| title | Diagnosing and Managing Uveitis Associated with Immune Checkpoint Inhibitors: A Review |
| title_full | Diagnosing and Managing Uveitis Associated with Immune Checkpoint Inhibitors: A Review |
| title_fullStr | Diagnosing and Managing Uveitis Associated with Immune Checkpoint Inhibitors: A Review |
| title_full_unstemmed | Diagnosing and Managing Uveitis Associated with Immune Checkpoint Inhibitors: A Review |
| title_short | Diagnosing and Managing Uveitis Associated with Immune Checkpoint Inhibitors: A Review |
| title_sort | diagnosing and managing uveitis associated with immune checkpoint inhibitors a review |
| topic | immune checkpoint inhibitor uveitis Vogt-Koyanagi-Harada birdshot-like uveitis immunotherapy CTLA-4 inhibitors |
| url | https://www.mdpi.com/2075-4418/14/3/336 |
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