Dynamic Thiol Disulphide Homeostasis In Patients Diagnosed With Acute Pulmonary Thromboembolism In Emergency Department
INTRODUCTION: This study aims to investigate the dynamic thiol-disulfide balance in the early period of patients diagnosed with acute pulmonary thromboembolism in the emergency department. METHODS: Serum thiol-disulfide levels in venous blood samples drawn from 58 patients diagnosed with acute pulmo...
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| Format: | Article |
| Language: | English |
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Ankara Yildirim Beyazit University
2021-03-01
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| Series: | Ankara Medical Journal |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=amj&un=AMJ-14890 |
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| author | Gül Pamukçu Günaydın Fatih Tanrıverdi SERKAN DEMİRCAN FERHAT İÇME Yavuz Otal Yucel Yuzbasioglu erdem haytaç Pervin Baran Cemile Bicer |
| author_facet | Gül Pamukçu Günaydın Fatih Tanrıverdi SERKAN DEMİRCAN FERHAT İÇME Yavuz Otal Yucel Yuzbasioglu erdem haytaç Pervin Baran Cemile Bicer |
| author_sort | Gül Pamukçu Günaydın |
| collection | DOAJ |
| description | INTRODUCTION: This study aims to investigate the dynamic thiol-disulfide balance in the early period of patients diagnosed with acute pulmonary thromboembolism in the emergency department. METHODS: Serum thiol-disulfide levels in venous blood samples drawn from 58 patients diagnosed with acute pulmonary embolism in the emergency department were analyzed using the newly developed Erel-Neşelioğlu method, and the results were compared with the measurements of the healthy control group. In the emergency department, the pre-diagnosis of pulmonary embolism was considered with clinical and laboratory findings and confirmed with contrast-enhanced thorax computed tomography angiogram. RESULTS: Mean native thiol and total thiol levels were significantly lower in pulmonary embolism patients compared to the control group (308.53 +- 78; 414.13 +- 50.86; p <0.002; 346.03 +- 81.13; 453.05 +- 52.46 μmol/l, p <0.003 respectively). Disulphide/native thiol and disulphide/total thiol ratios were found to be significantly higher in pulmonary embolism patients compared to the control group (p <0.001). DISCUSSION AND CONCLUSION: Thiol-disulfide balance is altered oxidatively in patients with pulmonary embolism. This may play a role in the pathogenesis of the disease. |
| first_indexed | 2024-04-10T12:39:05Z |
| format | Article |
| id | doaj.art-0813cbb061f247e0ac59264ad8ed71bf |
| institution | Directory Open Access Journal |
| issn | 2148-4570 |
| language | English |
| last_indexed | 2024-04-10T12:39:05Z |
| publishDate | 2021-03-01 |
| publisher | Ankara Yildirim Beyazit University |
| record_format | Article |
| series | Ankara Medical Journal |
| spelling | doaj.art-0813cbb061f247e0ac59264ad8ed71bf2023-02-15T16:14:23ZengAnkara Yildirim Beyazit UniversityAnkara Medical Journal2148-45702021-03-01211929810.5505/amj.2021.14890AMJ-14890Dynamic Thiol Disulphide Homeostasis In Patients Diagnosed With Acute Pulmonary Thromboembolism In Emergency DepartmentGül Pamukçu Günaydın0Fatih Tanrıverdi1SERKAN DEMİRCAN2FERHAT İÇME3Yavuz Otal4Yucel Yuzbasioglu5erdem haytaç6Pervin Baran7Cemile Bicer8Yıldırım Beyazıt University, Department Of Emergency Medicine, AnkaraYıldırım Beyazıt University, Department Of Emergency Medicine, AnkaraYıldırım Beyazıt University, Department Of Emergency Medicine, AnkaraAnkara City Hospital, Department Of Emergency Medicine, AnkaraAnkara City Hospital, Department Of Emergency Medicine, AnkaraUniversity Of Health Sciences, Gülhane Medical School, Department Of Emergency Medicine, AnkaraYıldırım Beyazıt University, Department Of Emergency Medicine, AnkaraAnkara City Hospital, Medical Biochemistry Clinic, AnkaraYıldırım Beyazıt University, Department Of Medical Biochemistry, AnkaraINTRODUCTION: This study aims to investigate the dynamic thiol-disulfide balance in the early period of patients diagnosed with acute pulmonary thromboembolism in the emergency department. METHODS: Serum thiol-disulfide levels in venous blood samples drawn from 58 patients diagnosed with acute pulmonary embolism in the emergency department were analyzed using the newly developed Erel-Neşelioğlu method, and the results were compared with the measurements of the healthy control group. In the emergency department, the pre-diagnosis of pulmonary embolism was considered with clinical and laboratory findings and confirmed with contrast-enhanced thorax computed tomography angiogram. RESULTS: Mean native thiol and total thiol levels were significantly lower in pulmonary embolism patients compared to the control group (308.53 +- 78; 414.13 +- 50.86; p <0.002; 346.03 +- 81.13; 453.05 +- 52.46 μmol/l, p <0.003 respectively). Disulphide/native thiol and disulphide/total thiol ratios were found to be significantly higher in pulmonary embolism patients compared to the control group (p <0.001). DISCUSSION AND CONCLUSION: Thiol-disulfide balance is altered oxidatively in patients with pulmonary embolism. This may play a role in the pathogenesis of the disease.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=amj&un=AMJ-14890pulmonary embolismdisulfidessulfhydryl compoundsemergency medicine. |
| spellingShingle | Gül Pamukçu Günaydın Fatih Tanrıverdi SERKAN DEMİRCAN FERHAT İÇME Yavuz Otal Yucel Yuzbasioglu erdem haytaç Pervin Baran Cemile Bicer Dynamic Thiol Disulphide Homeostasis In Patients Diagnosed With Acute Pulmonary Thromboembolism In Emergency Department Ankara Medical Journal pulmonary embolism disulfides sulfhydryl compounds emergency medicine. |
| title | Dynamic Thiol Disulphide Homeostasis In Patients Diagnosed With Acute Pulmonary Thromboembolism In Emergency Department |
| title_full | Dynamic Thiol Disulphide Homeostasis In Patients Diagnosed With Acute Pulmonary Thromboembolism In Emergency Department |
| title_fullStr | Dynamic Thiol Disulphide Homeostasis In Patients Diagnosed With Acute Pulmonary Thromboembolism In Emergency Department |
| title_full_unstemmed | Dynamic Thiol Disulphide Homeostasis In Patients Diagnosed With Acute Pulmonary Thromboembolism In Emergency Department |
| title_short | Dynamic Thiol Disulphide Homeostasis In Patients Diagnosed With Acute Pulmonary Thromboembolism In Emergency Department |
| title_sort | dynamic thiol disulphide homeostasis in patients diagnosed with acute pulmonary thromboembolism in emergency department |
| topic | pulmonary embolism disulfides sulfhydryl compounds emergency medicine. |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=amj&un=AMJ-14890 |
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