Features of biliary tract diseases in ketamine abusers: a systematic review of case reports
Abstract Background and aims Anesthesiologists prefer ketamine for certain surgeries due to its effectiveness as a non-competitive inhibitor of the N-methyl-D-aspartate receptor in the brain. Recently, this agent has also shown promise as an antidepressant. However, ketamine can cause hallucinogenic...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13256-024-04421-6 |
| _version_ | 1797274486348709888 |
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| author | Alireza Teymouri Hadis Nasoori Maryamsadat Fakheri Aref Nasiri |
| author_facet | Alireza Teymouri Hadis Nasoori Maryamsadat Fakheri Aref Nasiri |
| author_sort | Alireza Teymouri |
| collection | DOAJ |
| description | Abstract Background and aims Anesthesiologists prefer ketamine for certain surgeries due to its effectiveness as a non-competitive inhibitor of the N-methyl-D-aspartate receptor in the brain. Recently, this agent has also shown promise as an antidepressant. However, ketamine can cause hallucinogenic effects and is sometimes abused as an illicit drug. Ketamine abuse has been associated with liver and bile duct complications. This systematic study aims to better understand cholangiopathy in ketamine abusers by reviewing case reports. Methods and material In this systematic review, a comprehensive literature search was conducted with the terms “biliary tract diseases” and “ketamine”. Case reports and case series of adult patients with documented ketamine abuse and reported cholangiopathy or biliary tract disease were included. We extracted the data of relevant information and the results were reported through narrative synthesis and descriptive statistics. Results A total of 48 studies were initially identified, and 11 studies were finally included in the review. The mean age of the patients was 25.88 years. Of the 17 patients, 64.7% were men. Symptoms often included abdominal pain, nausea, and vomiting. Most patients were discharged with improved symptoms and liver function. Common bile duct dilation and other findings were observed in imaging results and other diagnostic studies. Conclusion This review highlights the diverse presentations and diagnostic modalities used in ketamine-induced cholangiography. These patients tend to be young men with deranged liver function tests and abdominal pain, which should be taken into consideration. These patients often require a multidisciplinary approach in their management. |
| first_indexed | 2024-03-07T14:59:04Z |
| format | Article |
| id | doaj.art-0814efb8930b4d7cbb1e126b015e75a9 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-03-07T14:59:04Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-0814efb8930b4d7cbb1e126b015e75a92024-03-05T19:14:34ZengBMCJournal of Medical Case Reports1752-19472024-03-0118111110.1186/s13256-024-04421-6Features of biliary tract diseases in ketamine abusers: a systematic review of case reportsAlireza Teymouri0Hadis Nasoori1Maryamsadat Fakheri2Aref Nasiri3Department of Surgery, School of Medicine, Tehran University of Medical SciencesFaculty of Pharmacy, Tehran Medical Science, Islamic Azad UniversityDepartment of Physical Medicine and Rehabilitation, School of Medicine, Shiraz University of Medical SciencesDepartment of Physical Medicine and Rehabilitation, School of Medicine, Shiraz University of Medical SciencesAbstract Background and aims Anesthesiologists prefer ketamine for certain surgeries due to its effectiveness as a non-competitive inhibitor of the N-methyl-D-aspartate receptor in the brain. Recently, this agent has also shown promise as an antidepressant. However, ketamine can cause hallucinogenic effects and is sometimes abused as an illicit drug. Ketamine abuse has been associated with liver and bile duct complications. This systematic study aims to better understand cholangiopathy in ketamine abusers by reviewing case reports. Methods and material In this systematic review, a comprehensive literature search was conducted with the terms “biliary tract diseases” and “ketamine”. Case reports and case series of adult patients with documented ketamine abuse and reported cholangiopathy or biliary tract disease were included. We extracted the data of relevant information and the results were reported through narrative synthesis and descriptive statistics. Results A total of 48 studies were initially identified, and 11 studies were finally included in the review. The mean age of the patients was 25.88 years. Of the 17 patients, 64.7% were men. Symptoms often included abdominal pain, nausea, and vomiting. Most patients were discharged with improved symptoms and liver function. Common bile duct dilation and other findings were observed in imaging results and other diagnostic studies. Conclusion This review highlights the diverse presentations and diagnostic modalities used in ketamine-induced cholangiography. These patients tend to be young men with deranged liver function tests and abdominal pain, which should be taken into consideration. These patients often require a multidisciplinary approach in their management.https://doi.org/10.1186/s13256-024-04421-6KetamineSubstance abuseBiliary tract diseaseCholangiopathy |
| spellingShingle | Alireza Teymouri Hadis Nasoori Maryamsadat Fakheri Aref Nasiri Features of biliary tract diseases in ketamine abusers: a systematic review of case reports Journal of Medical Case Reports Ketamine Substance abuse Biliary tract disease Cholangiopathy |
| title | Features of biliary tract diseases in ketamine abusers: a systematic review of case reports |
| title_full | Features of biliary tract diseases in ketamine abusers: a systematic review of case reports |
| title_fullStr | Features of biliary tract diseases in ketamine abusers: a systematic review of case reports |
| title_full_unstemmed | Features of biliary tract diseases in ketamine abusers: a systematic review of case reports |
| title_short | Features of biliary tract diseases in ketamine abusers: a systematic review of case reports |
| title_sort | features of biliary tract diseases in ketamine abusers a systematic review of case reports |
| topic | Ketamine Substance abuse Biliary tract disease Cholangiopathy |
| url | https://doi.org/10.1186/s13256-024-04421-6 |
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