Novel Substituted Heteroaromatic Piperazine and Piperidine Derivatives as Inhibitors of Human Enterovirus 71 and Coxsackievirus A16
A series of substituted heteroaromatic piperazine and piperidine derivatives were found through virtual screening based on the structure of human enterovirus 71 capsid protein VP1. The preliminary biological evaluation revealed that compounds 8e and 9e have potent activity against EV71 and Coxsackie...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2013-04-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/18/5/5059 |
| _version_ | 1818563739705671680 |
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| author | Xian Zhang Hongliang Wang Yuhuan Li Ruiyuan Cao Wu Zhong Zhibing Zheng Gang Wang Junhai Xiao Song Li |
| author_facet | Xian Zhang Hongliang Wang Yuhuan Li Ruiyuan Cao Wu Zhong Zhibing Zheng Gang Wang Junhai Xiao Song Li |
| author_sort | Xian Zhang |
| collection | DOAJ |
| description | A series of substituted heteroaromatic piperazine and piperidine derivatives were found through virtual screening based on the structure of human enterovirus 71 capsid protein VP1. The preliminary biological evaluation revealed that compounds 8e and 9e have potent activity against EV71 and Coxsackievirus A16 with low cytotoxicity. |
| first_indexed | 2024-12-14T01:20:19Z |
| format | Article |
| id | doaj.art-08176431b28a4e6d8c439699afc9fcbc |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-14T01:20:19Z |
| publishDate | 2013-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-08176431b28a4e6d8c439699afc9fcbc2022-12-21T23:22:25ZengMDPI AGMolecules1420-30492013-04-011855059507110.3390/molecules18055059Novel Substituted Heteroaromatic Piperazine and Piperidine Derivatives as Inhibitors of Human Enterovirus 71 and Coxsackievirus A16Xian ZhangHongliang WangYuhuan LiRuiyuan CaoWu ZhongZhibing ZhengGang WangJunhai XiaoSong LiA series of substituted heteroaromatic piperazine and piperidine derivatives were found through virtual screening based on the structure of human enterovirus 71 capsid protein VP1. The preliminary biological evaluation revealed that compounds 8e and 9e have potent activity against EV71 and Coxsackievirus A16 with low cytotoxicity.http://www.mdpi.com/1420-3049/18/5/5059virtual screeningpiperazine derivativepiperidine derivativesanti-EV71 activityanti-CVA16 activity |
| spellingShingle | Xian Zhang Hongliang Wang Yuhuan Li Ruiyuan Cao Wu Zhong Zhibing Zheng Gang Wang Junhai Xiao Song Li Novel Substituted Heteroaromatic Piperazine and Piperidine Derivatives as Inhibitors of Human Enterovirus 71 and Coxsackievirus A16 Molecules virtual screening piperazine derivative piperidine derivatives anti-EV71 activity anti-CVA16 activity |
| title | Novel Substituted Heteroaromatic Piperazine and Piperidine Derivatives as Inhibitors of Human Enterovirus 71 and Coxsackievirus A16 |
| title_full | Novel Substituted Heteroaromatic Piperazine and Piperidine Derivatives as Inhibitors of Human Enterovirus 71 and Coxsackievirus A16 |
| title_fullStr | Novel Substituted Heteroaromatic Piperazine and Piperidine Derivatives as Inhibitors of Human Enterovirus 71 and Coxsackievirus A16 |
| title_full_unstemmed | Novel Substituted Heteroaromatic Piperazine and Piperidine Derivatives as Inhibitors of Human Enterovirus 71 and Coxsackievirus A16 |
| title_short | Novel Substituted Heteroaromatic Piperazine and Piperidine Derivatives as Inhibitors of Human Enterovirus 71 and Coxsackievirus A16 |
| title_sort | novel substituted heteroaromatic piperazine and piperidine derivatives as inhibitors of human enterovirus 71 and coxsackievirus a16 |
| topic | virtual screening piperazine derivative piperidine derivatives anti-EV71 activity anti-CVA16 activity |
| url | http://www.mdpi.com/1420-3049/18/5/5059 |
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