Effect of enterovirus D68 on Lung Clearance Index in patients with cystic fibrosis: A case report
Cystic fibrosis (CF) causes airways obstruction and a decline in percent predicted forced expiratory volume in 1 s (FEV1%). FEV1% is an objective measure of a pulmonary exacerbation of CF; improvement in FEV1% is the endpoint used often to determine success of treatment of these acute declines in pu...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-01-01
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| Series: | Respiratory Medicine Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221300711530040X |
| _version_ | 1823963930096041984 |
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| author | Danielle M. Goetz Shipra Singh Daniel Sheehan |
| author_facet | Danielle M. Goetz Shipra Singh Daniel Sheehan |
| author_sort | Danielle M. Goetz |
| collection | DOAJ |
| description | Cystic fibrosis (CF) causes airways obstruction and a decline in percent predicted forced expiratory volume in 1 s (FEV1%). FEV1% is an objective measure of a pulmonary exacerbation of CF; improvement in FEV1% is the endpoint used often to determine success of treatment of these acute declines in pulmonary health. Lung Clearance Index (LCI), derived from multiple breath inert gas washout (MBW) test, measures ventilation inhomogeneity and small airways dysfunction. In the United States in 2014–2015, enterovirus D68 (EV-D68), a novel virus, led to hospitalizations in children because of respiratory distress. This report describes 2 patients with CF admitted for pulmonary exacerbations who were enrolled in an inpatient study to assess patient satisfaction and utility of MBW to measure LCI. Diagnostic testing indicated that these patients were infected with EV-D68. Although their FEV1% improved to their previous baseline following treatment for pulmonary exacerbation, it was discordant with LCI. We discuss LCI as a novel measure of pulmonary function and hypothesize that, based on these cases, it may be a more sensitive indicator of ongoing post-viral airways dysfunction as compared to FEV1%. |
| first_indexed | 2024-12-17T17:36:52Z |
| format | Article |
| id | doaj.art-0817ed27273d46f4a577da7645b35485 |
| institution | Directory Open Access Journal |
| issn | 2213-0071 |
| language | English |
| last_indexed | 2024-12-17T17:36:52Z |
| publishDate | 2015-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Respiratory Medicine Case Reports |
| spelling | doaj.art-0817ed27273d46f4a577da7645b354852022-12-21T21:39:18ZengElsevierRespiratory Medicine Case Reports2213-00712015-01-0116C12512710.1016/j.rmcr.2015.09.009Effect of enterovirus D68 on Lung Clearance Index in patients with cystic fibrosis: A case reportDanielle M. GoetzShipra SinghDaniel SheehanCystic fibrosis (CF) causes airways obstruction and a decline in percent predicted forced expiratory volume in 1 s (FEV1%). FEV1% is an objective measure of a pulmonary exacerbation of CF; improvement in FEV1% is the endpoint used often to determine success of treatment of these acute declines in pulmonary health. Lung Clearance Index (LCI), derived from multiple breath inert gas washout (MBW) test, measures ventilation inhomogeneity and small airways dysfunction. In the United States in 2014–2015, enterovirus D68 (EV-D68), a novel virus, led to hospitalizations in children because of respiratory distress. This report describes 2 patients with CF admitted for pulmonary exacerbations who were enrolled in an inpatient study to assess patient satisfaction and utility of MBW to measure LCI. Diagnostic testing indicated that these patients were infected with EV-D68. Although their FEV1% improved to their previous baseline following treatment for pulmonary exacerbation, it was discordant with LCI. We discuss LCI as a novel measure of pulmonary function and hypothesize that, based on these cases, it may be a more sensitive indicator of ongoing post-viral airways dysfunction as compared to FEV1%.http://www.sciencedirect.com/science/article/pii/S221300711530040XEnterovirus D68Viral infectionLung Clearance IndexMultiple breath washoutCystic fibrosis |
| spellingShingle | Danielle M. Goetz Shipra Singh Daniel Sheehan Effect of enterovirus D68 on Lung Clearance Index in patients with cystic fibrosis: A case report Respiratory Medicine Case Reports Enterovirus D68 Viral infection Lung Clearance Index Multiple breath washout Cystic fibrosis |
| title | Effect of enterovirus D68 on Lung Clearance Index in patients with cystic fibrosis: A case report |
| title_full | Effect of enterovirus D68 on Lung Clearance Index in patients with cystic fibrosis: A case report |
| title_fullStr | Effect of enterovirus D68 on Lung Clearance Index in patients with cystic fibrosis: A case report |
| title_full_unstemmed | Effect of enterovirus D68 on Lung Clearance Index in patients with cystic fibrosis: A case report |
| title_short | Effect of enterovirus D68 on Lung Clearance Index in patients with cystic fibrosis: A case report |
| title_sort | effect of enterovirus d68 on lung clearance index in patients with cystic fibrosis a case report |
| topic | Enterovirus D68 Viral infection Lung Clearance Index Multiple breath washout Cystic fibrosis |
| url | http://www.sciencedirect.com/science/article/pii/S221300711530040X |
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