Association between Serum Leptin Levels in Obesity and Type 2 Diabetes Mellitus
Introduction: It is hypothesised that leptin, the gene product of the obese gene plays an important role in regulating body weight and has a potential role as a treatment tool for obesity and Type 2 Diabetes Mellitus (T2DM). There is little documentation describing the relationship between serum lep...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2019-10-01
|
| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/13235/42410_CE[Ra1]_F(KM)_PF1(TR_KM)_IC_(AaG_OM)_PN(SL).pdf |
| _version_ | 1828475262929469440 |
|---|---|
| author | Raviraj Gawali Arun Bahulikar Deepak Sadashiv Phalgune Ajit Tambolkar |
| author_facet | Raviraj Gawali Arun Bahulikar Deepak Sadashiv Phalgune Ajit Tambolkar |
| author_sort | Raviraj Gawali |
| collection | DOAJ |
| description | Introduction: It is hypothesised that leptin, the gene product of the obese gene plays an important role in regulating body weight and has a potential role as a treatment tool for obesity and Type 2 Diabetes Mellitus (T2DM). There is little documentation describing the relationship between serum leptin and the indices of obesity such as Body Mass Index (BMI) and T2DM. Aim: To determine the relationship of serum leptin levels with BMI and type 2 DM patients. Materials and Methods: This observational study was conducted in 140 patients with known diagnosis of type 2 DM with and without obesity and non-diabetic patient with BMI ≥25 kg/m2 . Patient’s BMI and waist hip ratio were noted. Estimation of fasting serum leptin, fasting serum glucose, serum Total Cholesterol (TC), serum Triglycerides (TG), serum High Density Lipoprotein (HDL) cholesterol, serum Low-Density Lipoprotein (LDL) cholesterol and Very Low Density Lipoprotein (VLDL) cholesterol were done. Kruskal Wallis test and MannWhitney U test was used to compare median of continuous variables. Correlation analysis was done using Spearman’s correlation technique. Results: Median serum leptin level was significantly higher in patients who had DM and whose BMI was ≥25 kg/m2 . Fasting glucose, TC, LDL cholesterol, and VLDL cholesterol showed statistically significant and positive correlation, whereas HDL-cholesterol showed statistically significant and negative correlation with serum leptin levels. Conclusion: Serum leptin levels were higher in type 2 DM and obese patients. Fasting glucose, TC, LDL cholesterol, and VLDL cholesterol showed positive correlation, whereas HDL-cholesterol showed negative correlation with serum leptin levels. |
| first_indexed | 2024-12-11T06:10:14Z |
| format | Article |
| id | doaj.art-081872e482d94480b19900484e88c8d8 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-11T06:10:14Z |
| publishDate | 2019-10-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-081872e482d94480b19900484e88c8d82022-12-22T01:18:08ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2019-10-011310OC17OC1910.7860/JCDR/2019/42410.13235Association between Serum Leptin Levels in Obesity and Type 2 Diabetes MellitusRaviraj Gawali0Arun Bahulikar1Deepak Sadashiv Phalgune2Ajit Tambolkar3Senior Resident, Department of Medicine, Poona Hospital and Research Centre, Pune, Maharashtra, India.Head and Consultant Physician, Department of Medicine, Poona Hospital and Research Centre, Pune, Maharashtra, India.Consultant, Department of Research, Poona Hospital and Research Centre, Pune, Maharashtra, India.Consultant Physician, Department of Medicine, Poona Hospital and Research Centre, Pune, Maharashtra, India.Introduction: It is hypothesised that leptin, the gene product of the obese gene plays an important role in regulating body weight and has a potential role as a treatment tool for obesity and Type 2 Diabetes Mellitus (T2DM). There is little documentation describing the relationship between serum leptin and the indices of obesity such as Body Mass Index (BMI) and T2DM. Aim: To determine the relationship of serum leptin levels with BMI and type 2 DM patients. Materials and Methods: This observational study was conducted in 140 patients with known diagnosis of type 2 DM with and without obesity and non-diabetic patient with BMI ≥25 kg/m2 . Patient’s BMI and waist hip ratio were noted. Estimation of fasting serum leptin, fasting serum glucose, serum Total Cholesterol (TC), serum Triglycerides (TG), serum High Density Lipoprotein (HDL) cholesterol, serum Low-Density Lipoprotein (LDL) cholesterol and Very Low Density Lipoprotein (VLDL) cholesterol were done. Kruskal Wallis test and MannWhitney U test was used to compare median of continuous variables. Correlation analysis was done using Spearman’s correlation technique. Results: Median serum leptin level was significantly higher in patients who had DM and whose BMI was ≥25 kg/m2 . Fasting glucose, TC, LDL cholesterol, and VLDL cholesterol showed statistically significant and positive correlation, whereas HDL-cholesterol showed statistically significant and negative correlation with serum leptin levels. Conclusion: Serum leptin levels were higher in type 2 DM and obese patients. Fasting glucose, TC, LDL cholesterol, and VLDL cholesterol showed positive correlation, whereas HDL-cholesterol showed negative correlation with serum leptin levels.https://jcdr.net/articles/PDF/13235/42410_CE[Ra1]_F(KM)_PF1(TR_KM)_IC_(AaG_OM)_PN(SL).pdfcorrelationfasting glucoseserum triglycerides |
| spellingShingle | Raviraj Gawali Arun Bahulikar Deepak Sadashiv Phalgune Ajit Tambolkar Association between Serum Leptin Levels in Obesity and Type 2 Diabetes Mellitus Journal of Clinical and Diagnostic Research correlation fasting glucose serum triglycerides |
| title | Association between Serum Leptin Levels in Obesity and Type 2 Diabetes Mellitus |
| title_full | Association between Serum Leptin Levels in Obesity and Type 2 Diabetes Mellitus |
| title_fullStr | Association between Serum Leptin Levels in Obesity and Type 2 Diabetes Mellitus |
| title_full_unstemmed | Association between Serum Leptin Levels in Obesity and Type 2 Diabetes Mellitus |
| title_short | Association between Serum Leptin Levels in Obesity and Type 2 Diabetes Mellitus |
| title_sort | association between serum leptin levels in obesity and type 2 diabetes mellitus |
| topic | correlation fasting glucose serum triglycerides |
| url | https://jcdr.net/articles/PDF/13235/42410_CE[Ra1]_F(KM)_PF1(TR_KM)_IC_(AaG_OM)_PN(SL).pdf |
| work_keys_str_mv | AT ravirajgawali associationbetweenserumleptinlevelsinobesityandtype2diabetesmellitus AT arunbahulikar associationbetweenserumleptinlevelsinobesityandtype2diabetesmellitus AT deepaksadashivphalgune associationbetweenserumleptinlevelsinobesityandtype2diabetesmellitus AT ajittambolkar associationbetweenserumleptinlevelsinobesityandtype2diabetesmellitus |