A nomogram for predicting malignant cerebral artery infarction in the modern thrombectomy era
ObjectiveThis study aimed to develop and validate a nomogram to predict malignant cerebral artery infarction (MMI) after endovascular treatment (EVT) in patients with acute ischemic stroke (AIS) in the modern thrombectomy era.MethodsWe retrospectively analyzed data from a prospective cohort of conse...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.934051/full |
| _version_ | 1828105317793136640 |
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| author | Wenting Guo Jiali Xu Wenbo Zhao Wenbo Zhao Mengke Zhang Jin Ma Jian Chen Jiangang Duan Qingfeng Ma Haiqing Song Sijie Li Sijie Li Xunming Ji Xunming Ji Xunming Ji |
| author_facet | Wenting Guo Jiali Xu Wenbo Zhao Wenbo Zhao Mengke Zhang Jin Ma Jian Chen Jiangang Duan Qingfeng Ma Haiqing Song Sijie Li Sijie Li Xunming Ji Xunming Ji Xunming Ji |
| author_sort | Wenting Guo |
| collection | DOAJ |
| description | ObjectiveThis study aimed to develop and validate a nomogram to predict malignant cerebral artery infarction (MMI) after endovascular treatment (EVT) in patients with acute ischemic stroke (AIS) in the modern thrombectomy era.MethodsWe retrospectively analyzed data from a prospective cohort of consecutive patients with AIS who underwent EVT at Xuanwu hospital between January 2013 and June 2021. A multivariable logistic regression model was employed to construct the nomogram for predicting MMI after EVT. The discrimination and calibration of the nomogram were assessed both in the derivation and validation cohorts.ResultsA total of 605 patients were enrolled in this study, with 425 in the derivation cohort and 180 in the validation cohort. The nomogram was developed based on admission systolic blood pressure (SBP), the National Institute of Health Stroke Score (NIHSS), the Alberta Stroke Program Early Computed Tomography Score (ASPECTS), vessel occlusion site, EVT time window, and recanalization status. The nomogram displayed good discrimination with the area under the receiver operating characteristics (ROCs) curve (AUC) of 0.783 [95% confidence interval (CI), 0.726–0.840] in the derivation cohort and 0.806 (95% CI, 0.738–0.874) in the validation cohort. The calibration of the nomogram was good as well, with the Hosmer–Lemeshow test of p = 0.857 in the derivation cohort and p = 0.275 in the validation cohort.ConclusionIn the modern thrombectomy era, a nomogram containing admission SBP, NIHSS, ASPECTS, vessel occlusion site, EVT time window, and recanalization status may predict the risk of MMI after EVT in patients with AIS. |
| first_indexed | 2024-04-11T10:01:20Z |
| format | Article |
| id | doaj.art-0819e386103e44728069bf873b125470 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-11T10:01:20Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-0819e386103e44728069bf873b1254702022-12-22T04:30:25ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-09-011310.3389/fneur.2022.934051934051A nomogram for predicting malignant cerebral artery infarction in the modern thrombectomy eraWenting Guo0Jiali Xu1Wenbo Zhao2Wenbo Zhao3Mengke Zhang4Jin Ma5Jian Chen6Jiangang Duan7Qingfeng Ma8Haiqing Song9Sijie Li10Sijie Li11Xunming Ji12Xunming Ji13Xunming Ji14Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaBeijing Key Laboratory of Hypoxic Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Emergency, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaBeijing Key Laboratory of Hypoxic Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Emergency, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, ChinaBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, ChinaObjectiveThis study aimed to develop and validate a nomogram to predict malignant cerebral artery infarction (MMI) after endovascular treatment (EVT) in patients with acute ischemic stroke (AIS) in the modern thrombectomy era.MethodsWe retrospectively analyzed data from a prospective cohort of consecutive patients with AIS who underwent EVT at Xuanwu hospital between January 2013 and June 2021. A multivariable logistic regression model was employed to construct the nomogram for predicting MMI after EVT. The discrimination and calibration of the nomogram were assessed both in the derivation and validation cohorts.ResultsA total of 605 patients were enrolled in this study, with 425 in the derivation cohort and 180 in the validation cohort. The nomogram was developed based on admission systolic blood pressure (SBP), the National Institute of Health Stroke Score (NIHSS), the Alberta Stroke Program Early Computed Tomography Score (ASPECTS), vessel occlusion site, EVT time window, and recanalization status. The nomogram displayed good discrimination with the area under the receiver operating characteristics (ROCs) curve (AUC) of 0.783 [95% confidence interval (CI), 0.726–0.840] in the derivation cohort and 0.806 (95% CI, 0.738–0.874) in the validation cohort. The calibration of the nomogram was good as well, with the Hosmer–Lemeshow test of p = 0.857 in the derivation cohort and p = 0.275 in the validation cohort.ConclusionIn the modern thrombectomy era, a nomogram containing admission SBP, NIHSS, ASPECTS, vessel occlusion site, EVT time window, and recanalization status may predict the risk of MMI after EVT in patients with AIS.https://www.frontiersin.org/articles/10.3389/fneur.2022.934051/fullischemic strokethrombectomymalignantbrain edemanomogram |
| spellingShingle | Wenting Guo Jiali Xu Wenbo Zhao Wenbo Zhao Mengke Zhang Jin Ma Jian Chen Jiangang Duan Qingfeng Ma Haiqing Song Sijie Li Sijie Li Xunming Ji Xunming Ji Xunming Ji A nomogram for predicting malignant cerebral artery infarction in the modern thrombectomy era Frontiers in Neurology ischemic stroke thrombectomy malignant brain edema nomogram |
| title | A nomogram for predicting malignant cerebral artery infarction in the modern thrombectomy era |
| title_full | A nomogram for predicting malignant cerebral artery infarction in the modern thrombectomy era |
| title_fullStr | A nomogram for predicting malignant cerebral artery infarction in the modern thrombectomy era |
| title_full_unstemmed | A nomogram for predicting malignant cerebral artery infarction in the modern thrombectomy era |
| title_short | A nomogram for predicting malignant cerebral artery infarction in the modern thrombectomy era |
| title_sort | nomogram for predicting malignant cerebral artery infarction in the modern thrombectomy era |
| topic | ischemic stroke thrombectomy malignant brain edema nomogram |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.934051/full |
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