Dysregulated insulin secretion is associated with pancreatic β‐cell hyperplasia and direct acinar‐β‐cell trans‐differentiation in partially eNOS‐deficient mice

Dysregulated insulin secretion is associated with pancreatic β‐cell hyperplasia and direct acinar‐β‐cell trans‐differentiation in partially eNOS‐deficient mice

Abstract eNOS‐deficient mice were previously shown to develop hypertension and metabolic alterations associated with insulin resistance either in standard dietary conditions (eNOS−/− homozygotes) or upon high‐fat diet (HFD) (eNOS+/− heterozygotes). In the latter heterozygote model, the present study...

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Bibliographic Details
Main Authors: Michela Novelli, Matilde Masini, Cecilia Vecoli, Stefania Moscato, Niccola Funel, Anna Pippa, Letizia Mattii, Chiara Ippolito, Daniela Campani, Danilo Neglia, Pellegrino Masiello
Format: Article
Language:English
Published: Wiley 2022-08-01
Series:Physiological Reports
Subjects:
eNOS+/− heterozygote mice
Notch‐1 pathway
pancreatic exocrine‐endocrine transdifferentiation
pancreatic β cells
Online Access:https://doi.org/10.14814/phy2.15425

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