Estrogen Reverses HDAC Inhibitor-Mediated Repression of Aicda and Class-Switching in Antibody and Autoantibody Responses by Downregulation of miR-26a

Estrogen Reverses HDAC Inhibitor-Mediated Repression of Aicda and Class-Switching in Antibody and Autoantibody Responses by Downregulation of miR-26a

Estrogen contributes to females' strong antibody response to microbial vaccines and proneness to autoimmunity, particularly antibody-mediated systemic autoimmunity, in females. We have hypothesized that this is due to estrogen-mediated potentiation of class switch DNA recombination (CSR) and so...

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Bibliographic Details
Main Authors: Paolo Casali, Tian Shen, Yijiang Xu, Zhifang Qiu, Daniel P. Chupp, John Im, Zhenming Xu, Hong Zan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
Aicda
AID
antibody response
class switch DNA recombination
estrogen
estrogen receptor α
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00491/full

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