A New Alternative Tool to Analyse Glycosylation in Monoclonal Antibodies Based on Drop-Coating Deposition Raman imaging: A Proof of Concept

A New Alternative Tool to Analyse Glycosylation in Monoclonal Antibodies Based on Drop-Coating Deposition Raman imaging: A Proof of Concept

Glycosylation is considered a critical quality attribute of therapeutic proteins as it affects their stability, bioactivity, and safety. Hence, the development of analytical methods able to characterize the composition and structure of glycoproteins is crucial. Existing methods are time consuming, e...

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Bibliographic Details
Main Authors: Sabrina Hamla, Pierre-Yves Sacré, Allison Derenne, Ben Cowper, Erik Goormaghtigh, Philippe Hubert, Eric Ziemons
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Molecules
Subjects:
monoclonal antibodies (mAbs)
drop-coating deposition Raman imaging (DCDR)
multivariate curve resolution-alternating least square (MCR-ALS)
singular value decomposition (SVD)
nonlinear support vector regression (SVR)
P-vector
Online Access:https://www.mdpi.com/1420-3049/27/14/4405

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