Lipidome remodeling activities of DPA-EA in palmitic acid-stimulated HepG2 cells and the in vivo anti-obesity effect of the DPA-EA and DHA-EA mixture prepared from algae oil

Lipidome remodeling activities of DPA-EA in palmitic acid-stimulated HepG2 cells and the in vivo anti-obesity effect of the DPA-EA and DHA-EA mixture prepared from algae oil

Background: The nuclear receptor Nur77 has been demonstrated to play a vital role in the inflammatory response and cellular metabolisms, and its ligands exhibit efficacy in the treatment of inflammation-related diseases (e.g., improving mouse acute lung injury (ALI) and obesity. Recently, ω-3 polyun...

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Bibliographic Details
Main Authors: Hua Fang, Yin Cao, Jianyu Zhang, Xiumei Wang, Mengyu Li, Zhuan Hong, Zhen Wu, Meijuan Fang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
DPA-EA
lipidomics
anti-inflammation
anti-obesity
biomarker
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1146276/full

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