High-iron consumption decreases copper accumulation and colon length, and alters serum lipids
Abstract In this study, we aimed to demonstrate that a significant increase in dietary iron intake disrupts the regulation of copper availability, ultimately leading to systemic copper deficiency. To investigate this, we conducted experiments using five-week-old male weanling Sprague–Dawley rats fed...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2024-01-01
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| Series: | Applied Biological Chemistry |
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| Online Access: | https://doi.org/10.1186/s13765-024-00861-2 |
| _version_ | 1797273437354328064 |
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| author | Jisu Lee Hyun-Joo Lee Hyunsoo Jang Jae-Joon Lee Jung-Heun Ha |
| author_facet | Jisu Lee Hyun-Joo Lee Hyunsoo Jang Jae-Joon Lee Jung-Heun Ha |
| author_sort | Jisu Lee |
| collection | DOAJ |
| description | Abstract In this study, we aimed to demonstrate that a significant increase in dietary iron intake disrupts the regulation of copper availability, ultimately leading to systemic copper deficiency. To investigate this, we conducted experiments using five-week-old male weanling Sprague–Dawley rats fed diets based on AIN-93G with some modifications. These diets featured varying iron content, offering choices of adequate iron (~ 120 μg/g, near the upper limit [UL]) or high iron (~ 7544 μg/g), along with low (~ 0.3 μg/g), adequate (~ 6 μg/g), or high (~ 153 μg/g) levels of dietary copper over a 5-week period. Rats consuming the high-iron diets displayed anemia, reduced copper levels in their organs and feces, and shortened colon lengths. Increased dietary iron intake resulted in an overall reduction in copper distribution within the body, likely leading to severe copper deficiency-related disorders in the experimental rats. However, the physiological disturbances caused by a high-iron diet were prevented when additional copper was included in the rodent diet. Furthermore, high iron intake led to copper deprivation, and high iron consumption resulted in elevated serum cholesterol levels. However, increasing dietary copper consumption led to a decrease in overall serum cholesterol levels. Additionally, serum alkaline phosphate and aspartate aminotransferase levels were increased by high-iron feeding, regardless of dietary copper concentration, while alanine aminotransferase levels decreased. |
| first_indexed | 2024-03-07T14:44:17Z |
| format | Article |
| id | doaj.art-081c17206f164f588dd8f57f44796e61 |
| institution | Directory Open Access Journal |
| issn | 2468-0842 |
| language | English |
| last_indexed | 2024-03-07T14:44:17Z |
| publishDate | 2024-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Applied Biological Chemistry |
| spelling | doaj.art-081c17206f164f588dd8f57f44796e612024-03-05T20:03:08ZengSpringerOpenApplied Biological Chemistry2468-08422024-01-0167111510.1186/s13765-024-00861-2High-iron consumption decreases copper accumulation and colon length, and alters serum lipidsJisu Lee0Hyun-Joo Lee1Hyunsoo Jang2Jae-Joon Lee3Jung-Heun Ha4Department of Food Science and Nutrition, Dankook UniversitySchool of Wellness Industry Convergence, Major of Food & Nutrition, Hankyong National UniversityDepartment of Food Science and Nutrition, Dankook UniversityDepartment of Food and Nutrition, Chosun UniversityDepartment of Food Science and Nutrition, Dankook UniversityAbstract In this study, we aimed to demonstrate that a significant increase in dietary iron intake disrupts the regulation of copper availability, ultimately leading to systemic copper deficiency. To investigate this, we conducted experiments using five-week-old male weanling Sprague–Dawley rats fed diets based on AIN-93G with some modifications. These diets featured varying iron content, offering choices of adequate iron (~ 120 μg/g, near the upper limit [UL]) or high iron (~ 7544 μg/g), along with low (~ 0.3 μg/g), adequate (~ 6 μg/g), or high (~ 153 μg/g) levels of dietary copper over a 5-week period. Rats consuming the high-iron diets displayed anemia, reduced copper levels in their organs and feces, and shortened colon lengths. Increased dietary iron intake resulted in an overall reduction in copper distribution within the body, likely leading to severe copper deficiency-related disorders in the experimental rats. However, the physiological disturbances caused by a high-iron diet were prevented when additional copper was included in the rodent diet. Furthermore, high iron intake led to copper deprivation, and high iron consumption resulted in elevated serum cholesterol levels. However, increasing dietary copper consumption led to a decrease in overall serum cholesterol levels. Additionally, serum alkaline phosphate and aspartate aminotransferase levels were increased by high-iron feeding, regardless of dietary copper concentration, while alanine aminotransferase levels decreased.https://doi.org/10.1186/s13765-024-00861-2High-ironCopper deficiencyInsulin resistanceDyslipidemiaColon length |
| spellingShingle | Jisu Lee Hyun-Joo Lee Hyunsoo Jang Jae-Joon Lee Jung-Heun Ha High-iron consumption decreases copper accumulation and colon length, and alters serum lipids Applied Biological Chemistry High-iron Copper deficiency Insulin resistance Dyslipidemia Colon length |
| title | High-iron consumption decreases copper accumulation and colon length, and alters serum lipids |
| title_full | High-iron consumption decreases copper accumulation and colon length, and alters serum lipids |
| title_fullStr | High-iron consumption decreases copper accumulation and colon length, and alters serum lipids |
| title_full_unstemmed | High-iron consumption decreases copper accumulation and colon length, and alters serum lipids |
| title_short | High-iron consumption decreases copper accumulation and colon length, and alters serum lipids |
| title_sort | high iron consumption decreases copper accumulation and colon length and alters serum lipids |
| topic | High-iron Copper deficiency Insulin resistance Dyslipidemia Colon length |
| url | https://doi.org/10.1186/s13765-024-00861-2 |
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