Methylcobalamin promotes the differentiation of Schwann cells and remyelination in lysophosphatidylcholine-induced demyelination of the rat sciatic nerve

Methylcobalamin promotes the differentiation of Schwann cells and remyelination in lysophosphatidylcholine-induced demyelination of the rat sciatic nerve

Schwann cells (SCs) are constituents of the peripheral nervous system. The differentiation of SCs in injured peripheral nerves is critical for regeneration after injury. Methylcobalamin (MeCbl) is a vitamin B12 analog that is necessary for the maintenance of the peripheral nervous system. In this st...

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Bibliographic Details
Main Authors: Shunsuke eNishimoto, Hiroyuki eTanaka, Michio eOkamoto, Kiyoshi eOkada, Tsuyoshi eMurase, Hideki eYoshikawa
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Peripheral Nervous System
cAMP
Myelination
ERK signaling
Myelin Basic Protein
demyelinating disease
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00298/full

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