Modulation of gut microbiota and gut-generated metabolites by bitter melon results in improvement in the metabolic status in high fat diet-induced obese rats
The anti-obesity property of bitter melon powder (BMP) was investigated using a high-fat diet (HFD) obesity model. Obese rats were fed a HFD and treated with BMP for 8 weeks. We observed that BMP could effectively retard the body weight gain and improve the insulin sensitivity compared to the HFD gr...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-02-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464617307600 |
| _version_ | 1818919466587652096 |
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| author | Juan Bai Ying Zhu Ying Dong |
| author_facet | Juan Bai Ying Zhu Ying Dong |
| author_sort | Juan Bai |
| collection | DOAJ |
| description | The anti-obesity property of bitter melon powder (BMP) was investigated using a high-fat diet (HFD) obesity model. Obese rats were fed a HFD and treated with BMP for 8 weeks. We observed that BMP could effectively retard the body weight gain and improve the insulin sensitivity compared to the HFD group (p < .05). BMP also showed reduced endotoxin load as lipopolysaccharide-binding protein (LBP) level in the system. 16S rRNA sequencing indicated that BMP dramaticlly increased the relative abundance of Blautia and Allobaculum at the genus level. Metabolomic data revealed that dietary BMP changed metabolic profiles, including the metabolism of organic acids, amino acids and sugars. Additionally, some significant correlations was observed between specific gut microbiota at the genus level and effective biomarkers. These results reveal that the inhibition of insulin resistance and anti-inflammatory effect of BMP in obesity are illustrated with the restoration of gut microbiota and gut-generated metabolites. |
| first_indexed | 2024-12-20T01:06:18Z |
| format | Article |
| id | doaj.art-08206e41157c48a1bac857cb546c9daf |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-20T01:06:18Z |
| publishDate | 2018-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-08206e41157c48a1bac857cb546c9daf2022-12-21T19:58:50ZengElsevierJournal of Functional Foods1756-46462018-02-0141127134Modulation of gut microbiota and gut-generated metabolites by bitter melon results in improvement in the metabolic status in high fat diet-induced obese ratsJuan Bai0Ying Zhu1Ying Dong2School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, ChinaSchool of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, ChinaCorresponding author.; School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, ChinaThe anti-obesity property of bitter melon powder (BMP) was investigated using a high-fat diet (HFD) obesity model. Obese rats were fed a HFD and treated with BMP for 8 weeks. We observed that BMP could effectively retard the body weight gain and improve the insulin sensitivity compared to the HFD group (p < .05). BMP also showed reduced endotoxin load as lipopolysaccharide-binding protein (LBP) level in the system. 16S rRNA sequencing indicated that BMP dramaticlly increased the relative abundance of Blautia and Allobaculum at the genus level. Metabolomic data revealed that dietary BMP changed metabolic profiles, including the metabolism of organic acids, amino acids and sugars. Additionally, some significant correlations was observed between specific gut microbiota at the genus level and effective biomarkers. These results reveal that the inhibition of insulin resistance and anti-inflammatory effect of BMP in obesity are illustrated with the restoration of gut microbiota and gut-generated metabolites.http://www.sciencedirect.com/science/article/pii/S1756464617307600Bitter melonObesityGut microbiotaMetabolomics |
| spellingShingle | Juan Bai Ying Zhu Ying Dong Modulation of gut microbiota and gut-generated metabolites by bitter melon results in improvement in the metabolic status in high fat diet-induced obese rats Journal of Functional Foods Bitter melon Obesity Gut microbiota Metabolomics |
| title | Modulation of gut microbiota and gut-generated metabolites by bitter melon results in improvement in the metabolic status in high fat diet-induced obese rats |
| title_full | Modulation of gut microbiota and gut-generated metabolites by bitter melon results in improvement in the metabolic status in high fat diet-induced obese rats |
| title_fullStr | Modulation of gut microbiota and gut-generated metabolites by bitter melon results in improvement in the metabolic status in high fat diet-induced obese rats |
| title_full_unstemmed | Modulation of gut microbiota and gut-generated metabolites by bitter melon results in improvement in the metabolic status in high fat diet-induced obese rats |
| title_short | Modulation of gut microbiota and gut-generated metabolites by bitter melon results in improvement in the metabolic status in high fat diet-induced obese rats |
| title_sort | modulation of gut microbiota and gut generated metabolites by bitter melon results in improvement in the metabolic status in high fat diet induced obese rats |
| topic | Bitter melon Obesity Gut microbiota Metabolomics |
| url | http://www.sciencedirect.com/science/article/pii/S1756464617307600 |
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